Reakcija presadka proti gostitelju po transfuziji krvi in kako jo preprečimo = Transfusion associated graft vs. host disease and how to prevent it
Barbarić Kovačić, Aleksandra ; Stanišić, Slavica, dr. med. ; Zver, Samo, 1966-
Transfusion associated graft versus host disease (TA-GvHD) is a rare but fatal complication of blood components transfusion therapy and has over 90% mortality rate. Transfused donor T lymphocytes ...react against the recipient's cellular and tissue antigens. Interaction triggers lymphocyte activation and, consequently, destruction of target cells in the recipient's tissues . The reason that immune cells of the recipient do not respond appropriately is an incompetent recipient's immune system and immunodeficiency of the host. Exceptionally, HLA compatibility between the donor and the recipient may cause the same reaction. Most effective way to prevent TA-GvHD is irradiation of the blood components with ionizing radiation. UVA psoralen based pathogen inactivation is an equally effective preventive measure of TA-GvHD, but it is applicable only to platelets. For this reason, it is important that physicians identify patients at risk of developing TA-GvHD and consequentially always prescribe irradiated blood units. Blood units that need to be irradiated are erythrocytes and granulocytes, with the mentioned exception of platelets. Fresh frozen plasma, cryoprecipitate, blood derived medicines, such as albumins, immunoglobulins, blood clotting factors, and erythrocytes after thawing are not irradiated. The recommended central field irradiation dose is 25-50 Gy.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
PDF
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi