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Superantigens = SuperantigeniNarat, MojcaSuperantigens are bacterial, viral, retroviral and some naturally occurring proteins that can specifically activate a large proportion of T and/or B cells. In contrast to classical peptide antigen ... recognition, superantigens do not require processing to small peptides. T-cell superantigens interact with the immune system by binding to major histocompatibility complex (MHC) class II proteins outside the classical antigen binding groove and activate T cells through the variable region of the T cell receptor beta-chain. B-cell superantigens target B cells, which have restricted usage of variable heavy and light chain and by binding to immunoglobulins outside the conventional antigen binding site, stimulate a high frequency of B cells. Studies of T-celland B-cell superantigens are important since they are involved in many human diseases and represent a great tool in unravelling some of the basic mechanisms of immune response.Source: Zbornik Biotehniške fakultete Univerze v Ljubljani. Kmetijstvo. Zootehnika = Research reports [of the] Biotechnical Faculty University of Ljubljana. Agricultural issue. Zootechnica. - ISSN 1408-3434 ([Št.] 72, 1998, str. 25-36)Type of material - article, component partPublish date - 1998Language - englishCOBISS.SI-ID - 750984
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Narat, Mojca | 05008 |
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