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  • The role of bacterial proteinases in periodontal disease = Vloga bakterijskih proteinaz pri parodontalni bolezni
    Travis, James ; Potempa, Jan
    The organism Porphyromonas gingivalis has been found to be a major factor in the development od periodontitis. This bacterium secretes significant quantities of proteinases which can specifically ... activate the kallikrein/kinin, coagulation, and complement cascade systems to produce both a source of host nutrients and host proteinases at or near the site of infection. It is through utilization of the host-defense system to its own benefit that P. gingivalis manages to grow and proliferative throughout the gingival tissues, while causing the tissue damage associated with periodontal disease. Therefore, a suitable target for therapy are proteinases which activate the systems described earlier, rather than bacterial pathogens themselves. Instead of the use of antibiotics, the data from the reviewed literature suggest that either synthetic proteinase inhibitors and/or vaccinesdirected against proteinases from these organisms might be an alternative for therapy.
    Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 67, supl. 2, jun. 1998, str. II-25-II-27)
    Type of material - article, component part
    Publish date - 1998
    Language - english
    COBISS.SI-ID - 7906521

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