Virusna okužba, celično posredovan imunski odziv in genomski učinki vitamina D = Virus infection, cell immune response and genomic effects of vitamin D
Lojk, Jasna ; Marc, Janja
Ustrezen in pravočasen imunski odziv je ključen za obrambo vsakega organizma pred patogeni, vključno z virusi. Pri tem sodeluje veliko različnih celičnih tipov, ki v ustreznih stopnjah okužbe ...opravljajo svoje specifično delovanje: prepoznavanje in procesiranje patogenih organizmov, zbiranje imunskih celic na mesto okužbe, predstavljanje antigenov in proženje adaptivnega imunskega odziva preko proženja limfocitov B in T, nastanek protiteles in vzpostavitev imunskega spomina. Vsi posamezni koraki so tesno regulirani z medcelično komunikacijo in pozitivnimi ter negativnimi povratnimi zankami. Pri tem ključno vlogo igra tudi vitamin D, katerega glavna naloga je uravnavanje intenzitete in trajanja imunskega odziva preko spodbujanja delovanja regulatornih celic T, ki umirjajo imunski odziv in s tem preprečujejo pretirano aktivacijo, ki bi imela negativne posledice za organizem.
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