Cathepsin B and stefins in tumors of human central nervous system = Katepsin B in stefini pri možganskih tumorjih pri ljudeh
Strojnik, Tadej ...
Cysteine endopeptidase, cathepsin (Cat) B and its endogenous inhibitor, stefinA were found relevant for cancer progression of many neoplasms includinghuman brain tumors. Histological sections of a ...hundred primary tumorsof central nervous system (CNS) - 27 benign and 73 malignant, were reviewed and stained immunohistochemically for Cat B and stefin A. The immunohistochemical (IHC) staining of tumor cells, endothelial cells and macrophages was scored separately from 0 to 12. Cat B Immunohistochemical score in tumor and endothelial cell and was significantly higher in malignant tumors compared with benign tumors (p<0.0001). Significant correlation betweenimmunostaining of Cat B (scored together for tumor and endothelial cells) and clinical parameters, such as duration of symptoms, Karnofsky score,psycho-organic symptoms and histological score was demonstrated. Kaplan-Meier survival analysis indicated that total Cat B score above 8 was a significant predictor for shorter overall survival (p=0.003). In glioblastoma multiforme intense Cat B staining of endothelial cells was s significant predictor for shorter survival (p=0.003). Stefin A immunostaining was weak anddetected in a few benign and some malignant tumors, suggesting that this inhibitor alone is not sufficient in balancing proteolytic activity of Cat B. We conclude that specific immunostaining of Cat B in tumor and endothelial cells can be used to predict shorter survival in patients with primary tumors of CNS.
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