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Makrolidi in njihove farmakodinamične lastnosti = Macrolides and their pharmacodynamic propertiesGolmajer, Andrej ; Kozjek, FrancNekatere neugodne lastnosti eritromicina (nestabilnost v zelodčnem soku, kratka biološka razpolovna doba, manjša absorpcija na prazen zelodec) so vodile k odkritju novih makrolidov. Makrolidi se ... precej razlikujejo po farmakokinetičnih lastnostih, afiniteti do tkiv in intracelularni penetraciji.Novejši polsintetični makrolidi (klaritromicin, azitromicin, roksitromicin, diritromicin) imajo bistveno boljše farmakokinetične lastnosti kot eritromicin. Ker imajo daljšo biološko razpolovno dobo je terapija z njimi krajša. Jemlje se jih le 1-krat ali 2-krat dnevno, kar povečuje sodelovanje pacientov pri terapiji. Zaradi inhibicije citokroma P-450 IIIA4 v jetrih in enterocitih se lahko pri posameznih makrolidih (predvsem eritromicinu) pojavijo interakcije z nekaterimi zdravili, ki so pogosto v uporabi.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 51, št. 4, dec. 2000, str. 561-566)Type of material - article, component partPublish date - 2000Language - slovenianCOBISS.SI-ID - 847985
Author
Golmajer, Andrej |
Kozjek, Franc
Topics
antibiotiki |
makrolidi |
bakterijske infekcije |
farmakodinamika
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 51, št. 4, dec. 2000, str. 561-566)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Golmajer, Andrej | 18599 |
Kozjek, Franc | 00184 |
Source: Personal bibliographies
and: SICRIS
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