Uravnavanje od ubikvitin-proteasom odvisnega sistema razkroja beljakovin v poskusnih modelih mišične atrofije = Regulation of ubiquitin-proteasome-dependent protein breakdown in experimentalmodels in muscle atrophy
Červek, Matjaž ; Attaix, Didier ; Stekar, Jasna
Vedno več je dokazov, da ima od ATP-ubikvitina odvisni proteolitični sistem ključno vlogo pri razkroju beljakovin skeletnega mišičja. V različnih poskusnih modelih mišične atrofije poskušajo ...raziskovalci ugotoviti, kateri dejavniki in vplivi uravnavajo od ATP-ubikvitina odvisni razkroj beljakovin v skeletnih mišicah. Glede na dejavnike bi jih lahko v grobem razdelili na modele z vplivi prehrane (stradanje, beljakovinsko pomanjkljiva prehrana), z vplivi nerabe mišic (denervacija, breztežnost), z vplivi bolezenskih stanj (sepsa, acidoza, diabetes, opekline, kaheksija), z vplivi hormonov (inzulin, IGF-1, glukokortikoidi) in z vplivi citokinov (tumor nekroyni faktor-a, interleukin-1, interleukin-6).
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