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Stefin a and stefin B : markers for prognosis in operable squamous cell carcinoma of the head and neckStrojan, Primož ...Purpose: The aim of this study was to test the hypothesis about the protectiverole of high stefin A and stefin B concentrations in operable carcinoma of the head and neck. Methods and Materials: ... Stefins A and B concentrations were measured in tissue cytosols of nontumorous mucosa and primary tumors from 92 patients. For quantitative analysis of stefins in tumorcytosols, commercially available enzyme-linked immunosorbent assays were used. Results: Stefin A was upregulated in 53 patiens (higher concentrations were measured in tumor samples than in nontumorous mucosa) and was downregulated in 39 patients. The corresponding numbers for stefin B were 49 and 43, respectively. A significantly higher proportion of downregulated caseswere found among patients with disease re-appearance. In the Cox model, high stefin A concentrations appeared as independent predictors for favorable disease-free survival. Assuming a "broken stick" model, a significant increasein the recurrence rate after the threshold of 1063 ng/mgp (the 64th percentile in the group) was found, the hazard ratio reaching 3% of the reference value with doubling of the level of stefin A. These results were reconfirmed after pooling the data with two historical data sets into a uniform series involving 182 patients. Conclusions: A group of patients at high risk for disease progression was identified, characterized by the downregulated stefin A protein in the tumor compared with the nontumorous mucosa. Stefin A was recognized as a promising candidate marker for prognosis in patients with operable carcinoma of the head and neck.Source: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol. 68, no. 5, 2007, str. 1335-1341)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 22998233
Author
Strojan, Primož |
Aničin, Aleksandar |
Svetic, Branka |
Pohar Perme, Maja |
Šmid, Alojz, 1941- |
Kos, Janko, 1959-
Topics
Head And Neck Neoplasms |
Surgery |
Pathology |
Carcinoma, Small Cell |
Cysteine Proteinase Inhibitors |
Prognosis |
Cytosol |
Enzyme-Linked Immunosorbent Assay |
Disease-Free Survival |
Neoplasm Staging |
Cistenska proteinaza, inhibitorji |
Citosol |
Glava in vrat, novotvorbe |
Karcinom drobnocelični |
Prognoza |
Brez bolezni, preživetje |
Encimsko-vezani imunosorbentni test |
Novotvorba, stadij
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source: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Vol. 68, no. 5, 2007, str. 1335-1341)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Strojan, Primož | 14576 |
Aničin, Aleksandar | 36160 |
Svetic, Branka | 10518 |
Pohar Perme, Maja | 23437 |
Šmid, Alojz, 1941- | 02130 |
Kos, Janko, 1959- | 04648 |
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