General hospital Celje (SBCE)
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Avtoimunske motnje gibanjaKrajnc, Nik ; Savšek, LinaAvtoimunske motnje gibanja predstavljajo redko skupino bolezni, ki nastane zaradi pretiranega imunskega odziva proti nevronalnim antigenom. Patofiziološko jih razdelimo na motnje gibanja, povezane s ... protitelesi proti znotrajceličnim antigenom, ki pogosteje potekajo paraneoplastično in slabše odgovorijo na imunoterapijo, in motnje gibanja, povezane s protitelesi proti membranskim antigenom, ki so neposredno patogena, zato predstavljajo prognostično ugodnejšo skupino. V vsakodnevni praksi je uporabnejša klinična razdelitev na hipokinetične (parkinsonizem, sindrom otrdelosti, progresivni encefalomielitis z rigidnostjo in mioklonusom ) in hiperkinetične (tremor, mioklonus, distonija, horea, tiki, stereotipije in motnje gibanja, povezane s spanjem) motnje gibanja. Za diagnozo je ključna potrditev značilnih protiteles v serumu in/ali likvorju, preostale preiskave so nespecifične. Velik del avtoimunskih motenj gibanja je del paraneoplastičnega sindroma, zato je treba aktivno iskati spremljajoči tumor. Temelj zdravljenja predstavlja imunoterapija, s katero lahko dosežemo izboljšanje simptomov in celo popolno okrevanje.Source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 59, št. 4, 2020, str. 443-458)Type of material - article, component partPublish date - 2020Language - slovenianCOBISS.SI-ID - 52757763
Author
Krajnc, Nik |
Savšek, Lina
Topics
Movement disorders |
Autoimmune diseases |
Immunotherapy |
Motnje gibanja |
Avtoimunske bolezni |
Imunoterapija
source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 59, št. 4, 2020, str. 443-458)
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Krajnc, Nik | |
Savšek, Lina |
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