An efficient method of accessing new CF3-containing spiro-indene-proline derivatives has been developed based on a Cp*Rh(III)-catalyzed tandem C-H activation/3+2–annulation reaction of ...5-aryl-2-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-2-carboxylates with alkynes. An important feature of this spiro annulation process is the feasibility of dehydroproline moiety to act as a directing group in the selective activation of the aromatic C-H bond.
An efficient method of accessing new CFsub.3-containing spiro-indene-proline derivatives has been developed based on a Cp*Rh(III)-catalyzed tandem C-H activation/3+2–annulation reaction of ...5-aryl-2-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-2-carboxylates with alkynes. An important feature of this spiro annulation process is the feasibility of dehydroproline moiety to act as a directing group in the selective activation of the aromatic C-H bond.
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An efficient method for the selective preparation of trifluoro-methyl-substituted isoindolones has been developed via RhIII catalyzed C-H activation / 4 + 1-annulation of aryl ...hydroxamates with functionalized acceptor/acceptor diazo compounds as cross-coupling partners.
An efficient method of accessing new CF
-containing spiro-indene-proline derivatives has been developed based on a Cp*Rh(III)-catalyzed tandem C-H activation/3+2-annulation reaction of ...5-aryl-2-(trifluoromethyl)-3,4-dihydro-2
-pyrrole-2-carboxylates with alkynes. An important feature of this spiro annulation process is the feasibility of dehydroproline moiety to act as a directing group in the selective activation of the aromatic C-H bond.
