We examine how chief executive officer (CEO) narcissism influences the inter-organizational imitation of corporate strategy. We theorize that narcissistic CEOs are influenced more by the corporate ...strategies they experienced on other boards and less by the corporate strategies experienced by other directors. These effects are strengthened if the other firms to which the CEO has interlock ties have high status and if the CEO is powerful. Through longitudinal analyses of Fortune 500 companies' decisions (from 1997 to 2006) related to the acquisition emphasis of a firm's growth strategy and the firm's level of international diversification, we show that narcissistic CEOs are influenced by corporate strategies that they witnessed at other firms much more than other CEOs. In addition, relatively narcissistic CEOs not only strongly resist the influence of other directors' prior experience but also tend to demonstrate their superiority by adopting corporate strategies that are the opposite of what fellow directors' prior experience would suggest. Our theory and results highlight how CEO narcissism limits directors' influence over corporate strategy and influences CEOs' learning and information processing in making strategic decisions.
We explain why CEOs favor new directors who are similar in narcissistic tendency or have prior experience with other similarly narcissistic CEOs. Because powerful CEOs are more able to select such ...individuals onto their boards, CEO power is predicted to be positively associated with the above characteristics of new directors. These associations are expected to be stronger when a new director is more different from the CEO in salient demographic characteristics. Moreover, we explain why new directors favored by CEOs are more supportive of their decision making, strengthening the positive relationship between CEO narcissism and risk-taking spending. Our findings provide considerable support for our theory. This study introduces personality theories to corporate governance research on director selection and to research on how triads influence dyadic relations.
Jilin Oilfield is conducting a large-scale demonstration project on CO2 EOR (enhanced oil recovery) and storage in China. CO2 separated from a nearby natural gas reservoir (15–30 mol% CO2) is ...injected into the northern part of H59 oil block with permeability and porosity of 3.5 mD and 12.7%, respectively. After about six years of operation, nearly 0.26 million tons of CO2 (0.32 HCPV (hydrocarbon pore volume)) has been injected into the thin oil layers with well-developed natural fractures. In order to track the movement of CO2 in the oil reservoir, a microseismic monitoring program has been implemented to map the CO2 flow anisotropy and estimate its sweeping efficiency. Gas tracer testing has also been conducted to examine the inter-well connectivity. The temporal change of produced CO2 has been analyzed in a real-time mode to monitor the dynamic response in production wells. It is demonstrated that the migration of CO2 in the thin oil layers can be successfully detected by the microseismic technique, and the sweeping profiles of CO2 obtained from the inverted microseismic are in good agreement with the produced CO2 rate from production wells as well as the reservoir's petrophysical properties.
•Monitoring on CO2 migration in a tight oil reservoir during CCS-EOR.•Extensive implementation of microseismic monitoring to map the CO2 flow anisotropy.•Consistent observation from the microseismic, gas tracer and produced fluid analysis.
The latest advancement of CO2 flooding and sequestration theory and technology in China is systematically described, and the future development direction is put forward. Based on the geological ...characteristics of continental reservoirs, five theories and key technologies have been developed: (1) Enriched the understandings about the mass transfer characteristics of components between CO2 and crude oil in continental reservoirs, micro-flooding mechanism and sequestration mechanism of different geological bodies. (2) Established the design method of reservoir engineering parameters, injection-production control technology and development effect evaluation technology of CO2 flooding, etc. (3) Developed a series of production engineering technologies such as separated layer CO2 injection technology, high efficiency lifting technology, on-line wellbore corrosion monitoring and protection technology. (4) Innovated a series of surface engineering technology including CO2 capture technology, pipeline CO2 transportation, CO2 surface injection, and production gas circulation injection, etc. (5) Formed a series of supporting technologies including monitoring, and safety and environmental protection evaluation of CO2 flooding reservoir. On this basis, the technological development directions in the future have been put forward: (1) Breakthrough in low-cost CO2 capture technology to provide cheap CO2 gas source; (2) Improve the miscibility technology between CO2 and crude oil to enhance oil displacement efficiency; (3) Improve CO2 sweeping volume; (4) Develop more effective lifting tools and technologies; (5) Strengthen the research of basic theory and key technology of CO2 storage monitoring. CO2 flooding and sequestration in the Jilin Oilfield shows that this technology has broad application prospects in China.
Molecular subtyping may inform on prognosis and treatment response in bladder cancer. However, intratumoral molecular heterogeneity is not well studied in this disease and could complicate efforts to ...use molecular subtyping to guide patient management. To investigate intratumoral heterogeneity in bladder cancer, we examined molecular subtypes in a consecutive, retrospective cystectomy series of histologic variant bladder cancers and conventional urothelial carcinomas co-occurring with them. Molecular subtypes were assigned as per the approach reported by Lund University, an approach that incorporates cell cycle alterations and markers of differentiation, to give the urothelial-like, genomically unstable, basal-squamous, mesenchymal-like, and neuroendocrine-like subtypes. The majority (93%) of tumors were classified as urothelial like, genomically unstable, or basal squamous. Among patients with more than one tumor histology, 39% demonstrated molecular heterogeneity among the different tumor histologies. This was greatest for the basal-squamous subtype, 78% of which co-occurred with either urothelial-like or genomically unstable carcinoma (among cases with multiple histologies). In contrast, there was no co-occurrence of urothelial-like and genomically unstable carcinoma in the same patient. The findings indicate that bladder cancer is often molecularly heterogeneous, particularly in the basal-squamous subtype. This raises the concern for sampling error in laboratory tests that guide therapy based on molecular subtyping.
Patient summary: In this report, we investigated molecular diversity among different areas from the same tumor in patients with bladder cancer. We found that different areas from the same tumor are often molecularly different. We conclude that this biological diversity must be taken into account when interpreting clinical molecular tests performed on bladder cancer samples.
In bladder cancer, molecular subtype commonly differs between histologically distinct areas from the same tumor, most commonly in those with a component of the basal-squamous subtype. This suggests concern for sampling error in molecular tests based on molecular subtyping.
To better understand whether the transition by Asian countries toward market economies mirrors the path taken in the West, we ask how embedded network ties between equity analysts and the chief ...executive officers (CEOs) of the firms that they follow in India influence the accuracy of analysts' earnings forecasts. We contrast traditional institutions of caste and regional language with contemporary institutions, such as universities, as the locus of such ties. We posit that CEOs from the postreform generation are more likely to transfer material private information via their school ties, while prereform-generation CEOs favor caste or language ties. Contrasting domestic business groups (BGs) with Western multinational corporations (MNCs) as organizational contexts, we argue that BGs legitimate the transfer of private information along particularistic ties, whereas MNCs mitigate such transfers. Our conceptual framework is supported by analyses that draw on a sample of 1,552 earnings forecasts issued between 2001 and 2010 by 296 equity analysts. Our findings suggest that the embeddedness perspective should be broadened to incorporate the influence of the larger historical social structures within which economic action is embedded, and to view BGs as carriers and repositories that blend modern management practices with particularistic behavioral patterns among top executives.
Fluoroquinolone antibacterial agents (FQs) are the most commonly detected antibiotics in soil/groundwater which cause chronic effects on human beings as well as aquatic ecosystems. The current ...situation of the regulation, occurrence, fate, and sources of FQs in soil/groundwater was systematically analyzed in this paper. And then, the important factors affecting milligram per liter concentration of FQs sorption in soil, such as pH, cation exchange, clay minerals, organic content, surface complexation, and microbial degradation or transformation, were summarized. Actually, nanogram-microgram per liter concentration is detected frequently in soil/groundwater by far. Due to the extensive application of FQs and its relatively stable physicochemical characteristics, the higher concentration in soil/groundwater would appear in the coming decades which may exert a threat to freshwater and human beings. To the knowledge of the authors, no full-scale fate, occurrence, spatial, and temporal variations of FQs in soil/groundwater have been reported in the scientific literature. Therefore, it is recommended that more comprehensive studies are required to fill knowledge gaps in low-concentration transport, fate and occurrence, spatial, and temporal variations of FQs in soil/groundwater and their potential risk assessment to human and ecosystem.
Our paper examines the initial compensation of new CEOs hired in turnaround situations. Building on prior literature on executive job demands, we posit that new CEOs hired in turnaround situations ...will receive higher pay, particularly higher performance-based pay, and that the pay premium will incentivize them to undertake retrenchment and restructuring turnaround initiatives. An interaction between pay premium and CEO credentials is shown to have a stronger effect on the extent to which firms engage in such turnaround initiatives. Our empirical results, based on 98 new CEOs hired in 223 turnaround situations, largely support our arguments. We discuss the contribution of our study to the CEO compensation, executive job demands, and corporate turnaround literature.
Mainly driven by the clinical need, molecular genetic testing has been integrated into the standard patient care of cancer management including colorectal cancer (CRC) for various clinical purposes. ...A proper selection of anti-cancer therapies relies on information achieved by molecular genetic analysis. Also, molecular findings are often necessary or helpful in screening, diagnosis and prognosis of CRC and related diseases/syndromes. New molecular classification may profoundly alter the current understanding and clinical management of CRC. As a powerful sequencing tool, next generation sequencing has become the main platform of conducting cancer related molecular diagnostic tests. In this review, molecular biomarkers widely used in the current practice of CRC management are briefly discussed according to their clinical significance.
Selective BRAF inhibitors, vemurafenib and dabrafenib, and the MEK inhibitor, trametinib, have been approved for treatment of metastatic melanomas with a BRAF p.V600E mutation. The clinical ...significance of non-codon 600 mutations remains unclear, in part, due to variation of kinase activity for different mutants.
In this study, we categorized BRAF mutations according to the reported mutant kinase activity. A total of 1027 lung cancer, colorectal cancer or melanoma specimens were submitted for clinical mutation detection by next generation sequencing.
Non-codon 600 mutations were observed in 37% of BRAF-mutated tumors. Of all BRAF mutants, 75% were kinase-activated, 15% kinase-impaired and 10% kinase-unknown. The most common kinase-impaired mutant involves codon 594, specifically, p.D594G (c.1781A > G) and p.D594N (c.1780G > A). Lung cancers showed significantly higher incidences of kinase-impaired or kinase-unknown mutants. Kinase-impaired BRAF mutants showed a significant association with concomitant activating KRAS or NRAS mutations, but not PIK3CA mutations, supporting the reported interaction of these mutations.
BRAF mutants with impaired or unknown kinase activity as well as concomitant kinase-impaired BRAF mutations and RAS mutations were detected in lung cancers, colorectal cancers and melanomas. Different therapeutic strategies based on the BRAF mutant kinase activity and the concomitant mutations may be worthwhile.
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