Nanotechnology was well developed during past decades and implemented in a broad range of industrial applications, which led to an inevitable release of nanomaterials into the environment and ...ecosystem. Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials in various fields, especially in the agricultural sector. Plants are the basic component of the ecosystem and the most important source of food for mankind; therefore, understanding the impacts of AgNPs on plant growth and development is crucial for the evaluation of potential environmental risks on food safety and human health imposed by AgNPs. The present review summarizes uptake, translocation, and accumulation of AgNPs in plants, and exemplifies the phytotoxicity of AgNPs on plants at morphological, physiological, cellular, and molecular levels. It also focuses on the current understanding of phytotoxicity mechanisms via which AgNPs exert their toxicity on plants. In addition, the tolerance mechanisms underlying survival strategy that plants adopt to cope with adverse effects of AgNPs are discussed.
Active removal of Na⁺ from the cytosol into the vacuole plays a critical role in salinity tissue tolerance, but another, often neglected component of this trait is Na⁺ retention in vacuoles. This ...retention is based on an efficient control of Na⁺-permeable slow- and fast-vacuolar channels that mediate the back-leak of Na⁺ into cytosol and, if not regulated tightly, could result in a futile cycle. This Tansley insight summarizes our current knowledge of regulation of tonoplast Na⁺-permeable channels and discusses the energy cost of vacuolar Na⁺ sequestration, under different scenarios. We also report on a phylogenetic and bioinformatic analysis of the plant two-pore channel family and the difference in its structure and regulation between halophytes and glycophytes, in the context of salinity tolerance.
Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The understanding of the mechanism of the epilepsies has advanced greatly in the last three decades, especially in ...terms of their cellular and molecular basis. However, despite the availability of ~30 anti-epileptic drugs (AEDs) with diverse molecular targets, there are still many challenges (e.g. drug resistance, side effects) in pharmacological treatment of epilepsies today. Because molecular mechanisms are integrated at the level of neuronal circuits, we suggest a shift in epilepsy treatment and research strategies from the “molecular” level to the “circuit” level. Recent technological advances have facilitated circuit mechanistic discovery at each level and have paved the way for many opportunities of novel therapeutic strategies and AED development toward precise circuit therapy.
This study aimed to reveal the mechanistic basis of the melatonin‐mediated amelioration of salinity stress in plants. Electrophysiological experiments revealed that melatonin decreased salt‐induced ...K+ efflux (a critical determinant of plant salt tolerance) in a dose‐ and time‐dependent manner and reduced sensitivity of the plasma membrane K+‐permeable channels to hydroxyl radicals. These beneficial effects of melatonin were abolished by NADPH oxidase blocker DPI. Transcriptome analyses revealed that melatonin induced 585 (448 up‐ and 137 down‐regulated) and 59 (54 up‐ and 5 down‐regulated) differentially expressed genes (DEGs) in the root tip and mature zone, respectively. The most noticeable changes in the root tip were melatonin‐induced increase in the expression of several DEGs encoding respiratory burst NADPH oxidases (OsRBOHA and OsRBOHF), calcineurin B‐like/calcineurin B‐like‐interacting protein kinase (OsCBL/OsCIPK), and calcium‐dependent protein kinase (OsCDPK) under salt stress. Melatonin also enhanced the expression of potassium transporter genes (OsAKT1, OsHAK1, and OsHAK5). Taken together, these results indicate that melatonin improves salt tolerance in rice by enabling K+ retention in roots, and that the latter process is conferred by melatonin scavenging of hydroxyl radicals and a concurrent OsRBOHF‐dependent ROS signalling required to activate stress‐responsive genes and increase the expression of K+ uptake transporters in the root tip.
Melatonin improves salt tolerance in rice by enabling K+ retention in roots; this process is conferred by melatonin scavenging of hydroxyl radicals and a concurrent OsRBOHF‐dependent ROS signalling required to activate stress‐responsive genes and increasing the expression of K+ uptake transporters, particularly OsHAK5, in the root tip.
Perovskite-based photocatalysts are of significant interest in the field of photocatalysis. To date, several perovskite material systems have been developed and their applications in visible light ...photocatalysis studied. This article provides a review of the visible light (λ > 400 nm) active perovskite-based photocatalyst systems. The materials systems are classified by the B site cations and their crystal structure, optical properties, electronic structure, and photocatalytic performance are reviewed in detail. Titanates, tantalates, niobates, vanadates, and ferrites form important photocatalysts which show promise in visible light-driven photoreactions. Along with simple perovskite (ABO3) structures, development of double/complex perovskites that are active under visible light is also reviewed. Various strategies employed for enhancing the photocatalytic performance have been discussed, emphasizing the specific advantages and challenges offered by perovskite-based photocatalysts. This review provides a broad overview of the perovskite photocatalysts, summarizing the current state of the work and offering useful insights for their future development.
Organic cocrystals based on noncovalent intermolecular interactions (weak interactions) have aroused interest owing to their unpredicted and versatile chemicophysical properties and their ...applications. In this Minireview, we highlight recent research on organic cocrystals on reducing the aggregation‐caused quenching (ACQ) effect, tuning light emission, ferroelectricity and multiferroics, optical waveguides, and stimuli‐responsiveness. We also summarize the progress made in this field including revealing the structure–property relationships and developing unusual properties. Moreover, we provide a discussion on current achievements, limitations and perspectives as well as some directions and inspiration for further investigation on organic cocrystals.
Crystal set: This Minireview provides a summary on current research into organic cocrystals (reducing the aggregation‐caused quenching (ACQ) effect, tuning light emission, ferroelectricity, multiferroics, optical waveguides, and stimuli‐responsiveness), their limitations and perspectives as well as some directions and inspiration for further investigation.
Physical cleansing has been a focal element in religious ceremonies for thousands of years. The prevalence of this practice suggests a psychological association between bodily purity and moral ...purity. In three studies, we explored what we call the "Macbeth effect"--that is, a threat to one's moral purity induces the need to cleanse oneself. This effect revealed itself through an increased mental accessibility of cleansing-related concepts, a greater desire for cleansing products, and a greater likelihood of taking antiseptic wipes. Furthermore, we showed that physical cleansing alleviates the upsetting consequences of unethical behavior and reduces threats to one's moral self-image. Daily hygiene routines such as washing hands, as simple and benign as they might seem, can deliver a powerful antidote to threatened morality, enabling people to truly wash away their sins.
On global scale, the current situation of pandemic is symptomatic of increased incidences of contagious diseases caused by pathogens. The faster spread of these diseases, in a moderately short ...timeframe, is threatening the overall population wellbeing and conceivably the economy. The inadequacy of conventional diagnostic tools in terms of time consuming and complex laboratory-based diagnosis process is a major challenge to medical care. In present era, the development of point-of-care testing (POCT) is in demand for fast detection of infectious diseases along with “on-site” results that are helpful in timely and early action for better treatment. In addition, POCT devices also play a crucial role in preventing the transmission of infectious diseases by offering real-time testing and lab quality microbial diagnosis within minutes. Timely diagnosis and further treatment optimization facilitate the containment of outbreaks of infectious diseases. Presently, efforts are being made to support such POCT by the technological development in the field of internet of medical things (IoMT). The IoMT offers wireless-based operation and connectivity of POCT devices with health expert and medical centre. In this review, the recently developed POC diagnostics integrated or future possibilities of integration with IoMT are discussed with focus on emerging and re-emerging infectious diseases like malaria, dengue fever, influenza A (H1N1), human papilloma virus (HPV), Ebola virus disease (EVD), Zika virus (ZIKV), and coronavirus (COVID-19). The IoMT-assisted POCT systems are capable enough to fill the gap between bioinformatics generation, big rapid analytics, and clinical validation. An optimized IoMT-assisted POCT will be useful in understanding the diseases progression, treatment decision, and evaluation of efficacy of prescribed therapy.
•Infectious diseases are serious but manageable using intelligent diagnostics.•Biosensing enables low detection of virus needed for viral infection management.•IoMT-integrated biosensor enable diagnostics at site-of-infection efficiently.•IoMT-supported POC-biosensing enable viral infection management in personalized manner.•POC-biosensing is needed for diseases diagnostics and therapy decision along with investigation.
Micro‐ and nanorobots have shown great potential for applications in various fields, including minimally invasive surgery, targeted therapy, cell manipulation, environmental monitoring, and water ...remediation. Recent progress in the design, fabrication, and operation of these miniaturized devices has greatly enhanced their versatility. In this report, the most recent progress on the manipulation of small‐scale robots based on power sources, such as magnetic fields, light, acoustic waves, electric fields, thermal energy, or combinations of these, is surveyed. The design and propulsion mechanism of micro‐ and nanorobots are the focus of this article. Their fabrication and applications are also briefly discussed.
Externally powered micro‐ and nanorobots are promising candidates for future biomedical applications. Recent progress on externally powered small‐scale robots is summarized based on their power sources. The emphasis is laid on the design and propulsion mechanism of the microrobots. The fabrication and application is briefly discussed as well.
Pure organic room temperature phosphorescence (RTP) has unique advantages and various potential applications. However, it is challengeable to achieve organic RTP under visible and near-infrared ...(NIR)-light excitation, especially in aqueous solution. Herein we assemble difluoroboron β-diketonate compounds to form organic nanoparticles (NPs) in water. The resulting NPs are able to show efficient RTP, effective uptake, and bright imaging of HeLa cells under both visible- and NIR-light excitation. More strikingly, spectroscopic study, single-crystal X-ray diffraction, and DFT calculation reveal that the efficient RTP in organic NPs is originated from dimers in their excited states. The multiple interactions and intermolecular charge transfer in the dimer structures are of significance in promoting the production of dimer triplet excited states and suppressing the nonradiative decays to boost the RTP under visible- and NIR-light irradiation in water.
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