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  • Retromer and sorting nexins in endosomal sorting
    Gallon, Matthew; Cullen, Peter J Biochemical Society transactions, 02/2015, Volume: 43, Issue: 1
    Journal Article
    Peer reviewed

    The evolutionarily conserved endosomal retromer complex rescues transmembrane proteins from the lysosomal degradative pathway and facilitates their recycling to other cellular compartments. Retromer ...
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2.
  • To degrade or not to degrad... To degrade or not to degrade: mechanisms and significance of endocytic recycling
    Cullen, Peter J; Steinberg, Florian Nature reviews. Molecular cell biology, 11/2018, Volume: 19, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Newly endocytosed integral cell surface proteins are typically either directed for degradation or subjected to recycling back to the plasma membrane. The sorting of integral cell surface proteins, ...
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  • Retromer: a master conducto... Retromer: a master conductor of endosome sorting
    Burd, Christopher; Cullen, Peter J Cold Spring Harbor perspectives in biology, 2014-Feb-01, 2014-02-01, 20140201, Volume: 6, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    The endosomal network comprises an interconnected network of membranous compartments whose primary function is to receive, dissociate, and sort cargo that originates from the plasma membrane and the ...
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  • Endosomal sorting and signa... Endosomal sorting and signalling: an emerging role for sorting nexins
    Cullen, Peter J Nature reviews. Molecular cell biology, 07/2008, Volume: 9, Issue: 7
    Journal Article
    Peer reviewed

    The endocytic network comprises a series of interconnected tubulo-vesicular membranous compartments that together regulate various sorting and signalling events. Although it is clear that defects in ...
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  • Retromer Binding to FAM21 a... Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation
    McGough, Ian J.; Steinberg, Florian; Jia, Da ... CB/Current biology, 07/2014, Volume: 24, Issue: 14
    Journal Article
    Peer reviewed
    Open access

    Retromer is a protein assembly that plays a central role in orchestrating export of transmembrane-spanning cargo proteins from endosomes into retrieval pathways destined for the Golgi apparatus and ...
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  • Actin-dependent endosomal r... Actin-dependent endosomal receptor recycling
    Simonetti, Boris; Cullen, Peter J Current opinion in cell biology, 02/2019, Volume: 56
    Journal Article
    Peer reviewed
    Open access

    Display omitted •Actin polymerization on endosomes is primarily controlled by the regulation of the WASH complex activity.•Endosomal actin restricts the lateral mobility of cargoes and associated ...
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  • Neuropilin-1 is a host fact... Neuropilin-1 is a host factor for SARS-CoV-2 infection
    Daly, James L; Simonetti, Boris; Klein, Katja ... Science, 11/2020, Volume: 370, Issue: 6518
    Journal Article
    Peer reviewed
    Open access

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for host cell attachment and entry. The host ...
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  • Sequence-dependent cargo re... Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR
    Simonetti, Boris; Danson, Chris M; Heesom, Kate J ... The Journal of cell biology, 11/2017, Volume: 216, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Endosomal recycling of transmembrane proteins requires sequence-dependent recognition of motifs present within their intracellular cytosolic domains. In this study, we have reexamined the role of ...
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  • SNX27-Retromer directly bin... SNX27-Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling
    Simonetti, Boris; Guo, Qian; Giménez-Andrés, Manuel ... PLoS biology, 04/2022, Volume: 20, Issue: 4
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    Peer reviewed
    Open access

    Coat complexes coordinate cargo recognition through cargo adaptors with biogenesis of transport carriers during integral membrane protein trafficking. Here, we combine biochemical, structural, and ...
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  • Mammalian copper homeostasi... Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1
    Curnock, Rachel; Cullen, Peter J Journal of cell science, 08/2020, Volume: 133, Issue: 16
    Journal Article
    Peer reviewed
    Open access

    The concentration of essential micronutrients, such as copper (used here to describe both Cu and Cu ), within the cell is tightly regulated to avoid their adverse deficiency and toxicity effects. ...
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