Combinatorial optimization problems are ubiquitous but difficult to solve. Hardware devices for these problems have recently been developed by various approaches, including quantum computers. ...Inspired by recently proposed quantum adiabatic optimization using a nonlinear oscillator network, we propose a new optimization algorithm simulating adiabatic evolutions of classical nonlinear Hamiltonian systems exhibiting bifurcation phenomena, which we call simulated bifurcation (SB). SB is based on adiabatic and chaotic (ergodic) evolutions of nonlinear Hamiltonian systems. SB is also suitable for parallel computing because of its simultaneous updating. Implementing SB with a field-programmable gate array, we demonstrate that the SB machine can obtain good approximate solutions of an all-to-all connected 2000-node MAX-CUT problem in 0.5 ms, which is about 10 times faster than a state-of-the-art laser-based machine called a coherent Ising machine. SB will accelerate large-scale combinatorial optimization harnessing digital computer technologies and also offer a new application of computational and mathematical physics.
We report the first quantum-key-distribution (QKD) systems capable of delivering sustainable, real-time secure keys continuously at rates exceeding 10 Mb/s. To achieve such rates, we developed ...high-speed postprocessing modules, achieving maximum data throughputs of 60 MC/s, 55 Mb/s, and 108 Mb/s for standalone operation of sifting, error correction, and privacy amplification modules, respectively. The photonic layer of the QKD systems features high-speed single-photon detectors based on self-differencing InGaAs avalanche photodiodes, phase encoding using an asymmetric Mach-Zehnder interferometer, and active stabilization of the interferometer phase and photon polarization. An efficient variant of the decoy-state BB84 protocol is implemented for the security analysis, with a large dataset size of 10 8 bits selected to mitigate finite-size effects. Over a 2-dB channel, a record secure key rate of 13.72 Mb/s has been achieved averaged over 4.4 days of operation. We confirm the robustness and long-term stability on a second QKD system continuously running for 1 month without any user invention.
The structure–property studies in unpolymerized and polymerized tannic acid incorporated hydrogels exhibited the presence of micron sized aggregates. The hydrogen bonded aggregates breaks at high ...temperatures for the unpolymerized and polymerized cases as evident from the scattering studies. The structural changes is clearly reflected in rheological properties for the unpolymerized case as a clear elastic to dissipative transition while the polymerized case exhibited dissipation even at higher temperatures.
Display omitted
Hydrogels made with semi-interpenetrating networks of the oligomerized polyphenol tannic acid, and poly(acrylamide), exhibit high stiffness and toughness. However, the structure property relationships that give rise to enhanced mechanical properties is not well understood. Herein, we systematically investigate the hydrogels using small angle X-ray scattering and small and Ultra-small angle neutron scattering within a wide length scale range (1 nm to 20 µm), polarized optical microscopy, and rheology. Small angle X-ray and neutron scattering reveal the presence of micron sized hydrogen bonded clusters in the hydrogels. Breaking of hydrogen bonded clusters above a critical solution temperature was clearly observed in the small angle neutron scattering data. Polarized optical microscopy show enhanced anisotropy for the gels with oligomerized tannic acid incorporated - when compared to gels with monomeric tannic acid. Rheological studies at varying temperatures nicely corroborate the structural changes observed at high temperatures and reveal a self-healing behavior of the gels. The knowledge gained from this study will aid in rational design of hydrogels for biomedical applications.
While previous studies have characterized the fatty acids and global lipid families of the chicken egg yolk, there have been no publications characterizing the individual lipids in these lipid ...families. Such an in-depth characterization of egg yolk lipids is essential to define the potential benefits of egg yolk consumption for the supply of structural and anti-inflammatory lipids. Historically, the major focus has been on the cholesterol content of eggs and the potential negative health benefits of this lipid, while ignoring the essential roles of cholesterol in membranes and as a precursor to other essential sterols. A detailed analysis of egg yolk lipids, using high-resolution mass spectrometric analyses and tandem mass spectrometry to characterize the fatty acid substituents of complex structural lipids, was used to generate the first in-depth characterization of individual lipids within lipid families. Egg yolks were isolated from commercial eggs (Full Circle Market) and lipids extracted with methyl-t-butylether before analyses via high-resolution mass spectrometry. This analytical platform demonstrates that chicken egg yolks provide a rich nutritional source of complex structural lipids required for lipid homeostasis. These include dominant glycerophosphocholines (GPC) (34:2 and 36:2), plasmalogen GPC (34:1, 36:1), glycerophosphoethanolamines (GPE) 38:4 and 36:2), plasmalogen GPE (36:2 and 34:1), glycerophosphoserines (36:2 and 38:4), glycerophosphoinositols (38:4), glycerophosphoglycerols (36:2), N-acylphosphatidylethanolamines (NAPE) (56:6), plasmalogen NAPE (54:4 and 56:6), sphingomyelins (16:0), ceramides (22:0 and 24:0), cyclic phosphatidic acids (16:0 and 18:0), monoacylglycerols (18:1 and 18:2), diacylglycerols (36:3 and 36:2), and triacylglycerols (52:3). Our data indicate that the egg yolk is a rich source of structural and energy-rich lipids. In addition, the structural lipids possess ω-3 and ω-6 fatty acids that are essential precursors of endogenous anti-inflammatory lipid mediators. These data indicate that eggs are a valuable nutritional addition to the diets of individuals that do not have cholesterol issues.
Common ecology quantifies human insurgency Johnson, Neil F; Bohorquez, Juan Camilo; Gourley, Sean ...
Nature (London),
12/2009, Volume:
462, Issue:
7275
Journal Article
Peer reviewed
Many collective human activities, including violence, have been shown to exhibit universal patterns. The size distributions of casualties both in whole wars from 1816 to 1980 and terrorist attacks ...have separately been shown to follow approximate power-law distributions. However, the possibility of universal patterns ranging across wars in the size distribution or timing of within-conflict events has barely been explored. Here we show that the sizes and timing of violent events within different insurgent conflicts exhibit remarkable similarities. We propose a unified model of human insurgency that reproduces these commonalities, and explains conflict-specific variations quantitatively in terms of underlying rules of engagement. Our model treats each insurgent population as an ecology of dynamically evolving, self-organized groups following common decision-making processes. Our model is consistent with several recent hypotheses about modern insurgency, is robust to many generalizations, and establishes a quantitative connection between human insurgency, global terrorism and ecology. Its similarity to financial market models provides a surprising link between violent and non-violent forms of human behaviour.
Significance: A non-destructive technique for accurately characterizing the spatial distribution of optical properties of soft tissue membranes may give improved outcomes in many tissue engineering ...applications.
Aim: This study aimed to develop a non-destructive macroscopic imaging technique that is sensitive to optical anisotropy, typical of fibrous components in soft tissue membranes, and can address some of the difficulties caused by the complex turbid nature of these tissues.
Approach: A near-infrared Mueller matrix imaging polarimeter employing logarithm decomposition was developed and used to conduct transmission measurements of all the polarization properties across the full thickness of bovine pericardium tissue.
Results: The full Mueller matrix was measured across a 70 mm × 70 mm sample of calf bovine pericardium and revealed significant retardance (linear and circular) and depolarization in this tissue. Regions with a uniform axis of optical anisotropy were identified. Mueller matrix imaging demonstrated that the exhibited circular retardance was sufficient to lead to possible misinterpretation of apparent fiber orientation when using conventional polarization imaging techniques for such tissues.
Conclusions: Mueller matrix imaging can identify regional distributions of optical anisotropy in calf bovine pericardium. This new capability is a promising development in non-destructive imaging for tissue selection.
Variations in mechanical properties of the extracellular matrix occurs in various processes, such as tissue fibrosis. The impact of changes in tissue stiffness on cell behaviour are studied
in vitro
...using various types of biomaterials and methods. Stiffness patterning of hydrogel scaffolds, through the use of stiffness gradients for instance, allows the modelling and studying of cellular responses to fibrotic mechanisms. Gelatine methacryloyl (GelMA) has been used extensively in tissue engineering for its inherent biocompatibility and the ability to precisely tune its mechanical properties. Visible light is now increasingly employed for crosslinking GelMA hydrogels as it enables improved cell survival when performing cell encapsulation. We report here, the photopatterning of mechanical properties of GelMA hydrogels with visible light and eosin Y as the photoinitiator using physical photomasks and projection with a digital micromirror device. Using both methods, binary hydrogels with areas of different stiffnesses and hydrogels with stiffness gradients were fabricated. Their mechanical properties were characterised using force indentation with atomic force microscopy, which showed the efficiency of both methods to spatially pattern the elastic modulus of GelMA according to the photomask or the projected pattern. Crosslinking through projection was also used to build constructs with complex shapes. Overall, this work shows the feasibility of patterning the stiffness of GelMA scaffolds, in the range from healthy to pathological stiffness, with visible light. Consequently, this method could be used to build
in vitro
models of healthy and fibrotic tissue and study the cellular behaviours involved at the interface between the two.
The development of personalised healthcare models to facilitate home-based healthcare will enable new strategies for treating chronic disease. Such personalised models that incorporate the ...physiological systems of the human body require a common 3D coordinate system in which different organ systems can be positioned and linked together. A common coordinate system for the human body requires a dataset of accurate whole-body geometries sufficient to characterise the population variation.
For this purpose, a prototype camera-based 3D imaging system has been developed at the Auckland Bioengineering Institute. Camera-based 3D reconstruction of the external geometry of the body, that is the skin surface, offers a relatively cheap and quick method to measure the body shape of many individuals. This imaging system captures coloured 3D data of the skin surface of individuals in both static and dynamic poses.
In this talk I will present the development of this prototype body scanner. I will also discuss an upcoming study in which we plan to image up to 400 New Zealanders to build a database of human models and the possible secondary use of this dataset for other researchers at the Auckland Bioengineering Institute and beyond.
Introduction
Horses with asthma or osteoarthritis frequently receive ω-3 fatty acid supplements. Docosahexaenoic (DHA; 22:6) and eicosapentaenoic (EPA; 20:5) acids are essential ω-3 fatty acid ...precursors of anti-inflammatory mediators and components of structural glycerophospholipids (GPL) that act as reservoirs of these fatty acids. Analysis of the incorporation of dietary DHA + EPA into GPL pools in different body compartments has not been undertaken in horses.
Objectives
We undertook a detailed study of dietary supplementation with DHA + EPA in horses and monitored incorporation into DHA- and EPA-containing glycerophosphocholines (GPC) 38:5, 38:6, 40:5, and 40:6 in plasma, synovial fluid (SF), and surfactant.
Methods
Horses (n = 20) were randomly assigned to the supplement or control group and evaluated on days 0, 30, 60, and 90. GPC in plasma, SF, and surfactant were measured by high-resolution mass spectrometry with less than 3 ppm mass error. Validation of DHA and EPA incorporation into these GPC was conducted utilizing MS
2
of the M + Cl
−
adducts of GPC.
Results
Dietary supplementation resulted in augmented levels of GPC 38:5, 38:6, 40:5, and 40:6 in all compartments. Maximum incorporation into GPCs was delayed until 60 days. Significant increases in the levels of GPC 38:5, 40:5, and 40:6, containing docosapentaenoic acid (DPA; 22:5), also was noted.
Conclusions
DHA and EPA supplementation results in augmented storage pools of ω-3 essential fatty acids in SF and surfactant GPC. This has the potential to improve the ability of anti-inflammatory mechanisms to resolve inflammatory pathways in these critical compartments involved in arthritis and asthma.
PDF
