A Ag-mediated C–H/P–H functionalization reaction of arylphosphine oxides with internal alkynes was described for the direct preparation of benzobphosphole oxides with a high yield. An unusual aryl ...migration on the P-atom derived from a C–P bond cleavage and a new C–P bond formation was also observed and demonstrated to proceed via the radical process.
The first highly enantioselective catalytic synthesis of P-stereogenic secondary phosphine-boranes was realized by the asymmetric addition of primary phosphine to electron-deficient alkenes with a ...newly developed unsymmetric bisphosphine (PCP′) pincer-nickel complex. Various P-stereogenic secondary phosphine-boranes were obtained in 57–92% yields with up to 99% ee and >20:1 dr. The follow-up alkylation upon P–C bond formation with alkyl halides provided a practical way to access P-chiral compounds with diverse functional groups.
A directing group‐free, ligand‐promoted palladium‐catalyzed C−H arylation of internal alkynes with simple arenes was developed. Alkenyl chlorides resulting from a 1,4‐chlorine migration or ...trisubstituted alkenes were produced in moderate to good yields depending on the type of alkyne.
A directing‐group‐free, ligand‐promoted palladium‐catalyzed C−H arylation of internal alkynes with simple arenes was developed. Alkenyl chlorides resulting from a 1,4‐chlorine migration or trisubstituted alkenes were produced in moderate to good yields depending on the type of alkyne.
A general and mild nickel‐catalyzed enantioselective C(sp2)−P cross‐coupling for synthesizing P‐stereogenic phosphine oxides has been developed. The asymmetric alkenylation/arylation of racemic ...secondary phosphine oxides with alkenyl/aryl bromides generated P‐stereogenic phosphine oxides with high yields and enantioselectivities. Various functional groups were tolerated, and the applications of this method were demonstrated through late‐stage functionalization and product transformations.
A nickel‐catalyzed asymmetric C(sp2)−P cross‐coupling for the synthesis of P‐stereogenic phosphine oxides under mild conditions is reported. The enantioselective alkenylation/arylation of racemic secondary phosphine oxides with alkenyl/aryl bromides provided P‐stereogenic phosphine oxides with high enantioselectivities of up to 99 % ee.
The catalytic asymmetric synthesis of P‐chiral phosphorus compounds is an important way to construct P‐chiral ligands. Herein, we report a new strategy that adopts the pyridinyl moiety as the ...coordinating group in the cobalt‐catalysed asymmetric nucleophilic addition/alkylation of secondary phosphine oxides. A series of tertiary phosphine oxides were generated with up to 99 % yield and 99.5 % ee, and with broad functional‐group tolerance. Mechanistic studies reveal that (R)‐secondary phosphine oxides preferentially interact with the cobalt catalysts to produce P‐stereogenic compounds.
The catalytic asymmetric synthesis of P‐chiral phosphorus compounds is an important way to construct P‐chiral ligands. Herein, we report a new strategy that adopts the pyridinyl moiety as the coordinating group in the cobalt‐catalysed asymmetric nucleophilic addition/alkylation of secondary phosphine oxides (SPOs). A series of tertiary phosphine oxides (TPOs) were generated with up to 99 % yield and 99.5 % ee, and with broad functional‐group tolerance.
•The role of Gaussian colored noises on the stability of tumor-immune responses to chemotherapy system is analyzed.•Both Gaussian colored noises have different influence on stability.•System occurs ...the noise-enhanced stability which is detected by the maximum Lyapunov exponent.
The influence of Gaussian colored noises on the stability of tumor-immune responses to chemotherapy system is analyzed. By means of the unified colored noise approximation of multidimensional stochastic dynamic system, the system is changed into the stochastic system with Gaussian white noises. I derive the analytic formula of the maximum Lyapunov exponent of system as a function of intensities and correlation times of Gaussian colored noises, then I find the noise-enhanced stability phenomenon, which is detected by the maximum Lyapunov exponent. Moreover, the correlation time τ1 of ξ1(t) influences the stability of steady state becomes unstable if τ1 → 0.15, which also increases as the correlation time τ2 of ξ2(t) increases. These indicate that, once tumor grows, by controlling the stochastic effect in process of chemotherapy, such as Gaussian colored noises, it is possible to control the stability of the tumor, which is very important for treatment. Especially, one could regulate the correlation time τ1 for this purpose.
A unique “clean‐lifting transfer” (CLT) technique that applies a controllable electrostatic force to transfer large‐area and high‐quality CVD‐grown graphene onto various rigid or flexible substrates ...is reported. The CLT technique without using any organic support or adhesives can produce residual‐free graphene films with large‐area processability, and has great potential for future industrial production of graphene‐based electronics or optoelectronics.
Enantioselective arylation of secondary β-C(sp3)–H bonds of 8-aminoquinoline amides was realized with a palladium catalyst. Chiral phosphoric amides and acids were used for the first time to control ...the stereoselectivity at the C–H bond cleavage step in the C–H activation reactions.
With the evolution of the technologies for IoV to be intelligent and interconnected, V2X communication technology serves as a core technology for information interaction among intelligent connected ...vehicles, and an important technology to realize environment sensing for future autonomous driving. In order to provide wireless communication services with ultra-low delay, ultra-high reliability and ultra-large bandwidth, this article proposes architectures of 5G-V2X communication networks by exploiting the technologies of 5G new radio (NR), network slicing, and deviceto- device communications. We discuss their principles and key features, and foresee the challenges, opportunities, and future research trends. The applications of related technologies of the software defined network (SND) and multi-access edge computing (MEC) are also introduced. Finally, the technologies of information security and privacy protection are identified to support the diverse services and applications in the future 5G-V2X networks.
The stability of tumor-immune responses to chemotherapy system with Gaussian colored noises and time delay is discussed by means of the maximum Lyapunov exponent. The unified colored noise ...approximation of multidimensional stochastic dynamic system with Gaussian colored and white noises is extended to the general case for the Gaussian colored noises having different self-correlation times and the correlated noises. We derive the analytic formula of the maximum Lyapunov exponent of system as a function of intensities and correlation times of Gaussian colored noises as well as delay, these parameters could change the stability of system between asymptotically stable and unstable, among, the system appears the noise and delay enhanced stability, which is detected by the maximum Lyapunov exponent.
