Summary The poor prognosis and rising incidence of esophageal cancer highlight the need for improved detection and prediction methods that are essential prior to treatment. Esophageal cancer is one ...of the most fatal malignancies worldwide, with a dramatic increase in incidence in the Western world occurring over the past few decades. Despite improvements in the management and treatment of esophageal cancer patients, the general outcome remains very poor for overall 5-year survival rates (∼10%) and 5-year postesophagectomy survival rates (∼15–40%). Esophageal cancer is often diagnosed during its advanced stages, the main reason being the lack of early clinical symptoms. In an attempt to improve the outcome of patients after surgery, such patients are often treated with neoadjuvent concurrent chemoradiotherapy (CCRT) in order to decrease tumor size. However, CCRT may enhance toxicity levels and possibly cause a delay in surgery for patients who respond poorly to CCRT. Thus, precise biomarkers that could predict or identify patients who may or may not respond well to CCRT can assist physicians in choosing the appropriate therapy for patients. Identifying susceptible gene and biomarkers can help in predicting the treatment response of patients while improving their survival rates.
Capacitively coupled chopper instrumentation amplifier (CCIA) is a classical topology for designing low-noise, low-power instrumentation amplifiers (IAs). However, CCIA has two significant ...limitations: chopping ripple and limited input impedance. Especially for ultra-low-noise applications, the chopping ripple of CCIA can easily saturate the amplifier. Hence, ripple reduction (RR) is required in the CCIA design. This article presents a CCIA with a newly proposed chopping RR technique, dynamic offset zeroing (DOZ). By introducing an ultra-low duty cycle zeroing phase in the normal chopping operation, the proposed DOZ technique can suppress the chopping ripple with a measured state-of-the-art reduction ratio of 61 dB while introducing negligible noise, power, and circuit overhead. In addition, a highly linear three-terminal varactor is proposed in a positive feedback loop (PFL) to boost the limited input impedance of the CCIA to be above 1 <inline-formula> <tex-math notation="LaTeX">\text{G}\Omega </tex-math></inline-formula>. The presented CCIA is implemented in a 180-nm CMOS technology and achieves a 13-nV/<inline-formula> <tex-math notation="LaTeX">\surd </tex-math></inline-formula>Hz input-referred noise density and a noise efficiency factor (NEF) of 1.3 while consuming 4.5-<inline-formula> <tex-math notation="LaTeX">\mu \text{W} </tex-math></inline-formula> power.
Background and Aims
The study objective was to compare the effectiveness of microwave ablation (MWA) and laparoscopic liver resection (LLR) on solitary 3–5‐cm HCC over time.
Approach and Results
From ...2008 to 2019, 1289 patients from 12 hospitals were enrolled in this retrospective study. Diagnosis of all lesions were based on histopathology. Propensity score matching was used to balance all baseline variables between the two groups in 2008–2019 (n = 335 in each group) and 2014–2019 (n = 257 in each group) cohorts, respectively. For cohort 2008–2019, during a median follow‐up of 35.8 months, there were no differences in overall survival (OS) between MWA and LLR (HR: 0.88, 95% CI 0.65–1.19, p = 0.420), and MWA was inferior to LLR regarding disease‐free survival (DFS) (HR 1.36, 95% CI 1.05–1.75, p = 0.017). For cohort 2014–2019, there was comparable OS (HR 0.85, 95% CI 0.56–1.30, p = 0.460) and approached statistical significance for DFS (HR 1.33, 95% CI 0.98–1.82, p = 0.071) between MWA and LLR. Subgroup analyses showed comparable OS in 3.1–4.0‐cm HCCs (HR 0.88, 95% CI 0.53–1.47, p = 0.630) and 4.1–5.0‐cm HCCs (HR 0.77, 95% CI 0.37–1.60, p = 0.483) between two modalities. For both cohorts, MWA shared comparable major complications (both p > 0.05), shorter hospitalization, and lower cost to LLR (all p < 0.001).
Conclusions
MWA might be a first‐line alternative to LLR for solitary 3–5‐cm HCC in selected patients with technical advances, especially for patients unsuitable for LLR.
Curcumin is an anticancer agent, but adverse effects and low bioavailability are its main drawbacks, which drives efforts in chemical modifications of curcumin. This study evaluated antiproliferative ...activity and cancer cell selectivity of a curcumin derivative, curcumin nicotinate (CN), in which two niacin molecules were introduced. Our data showed that CN effectively inhibited proliferation and clonogenic growth of colon (HCT116), breast (MCF-7) and nasopharyngeal (CNE2, 5-8F and 6-10B) cancer cells with IC
at 27.7 μM, 73.4 μM, 64.7 μM, 46.3 μM, and 31.2 μM, respectively. In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved. In non-transformed human mammary epithelial cells MCF10A, CN at 50 µM had no cytotoxicity and p53 was not activated, but curcumin at 12.5 µM activated p53 and p21 and inhibited MCF10A cell growth. These data suggest that CN inhibits cell growth and proliferation through p53-mediated apoptosis and cell cycle arrest with cancer cell selectivity.
Abstract
The Doppler effect is a universal wave phenomenon that has spurred a myriad of applications. In early manifestations, it was implemented by interference with a reference wave to infer linear ...velocities along the direction of motion, and more recently lateral and angular velocities using scalar phase structured light. A consequence of the scalar wave approach is that it is technically challenging to directly deduce the motion direction of moving targets. Here we overcome this challenge using vectorially structured light with spatially variant polarization, allowing the velocity and motion direction of a moving particle to be fully determined. Using what we call a vectorial Doppler effect, we conduct a proof of principle experiment and successfully measure the rotational velocity (magnitude and direction) of a moving isotropic particle. The instantaneous position of the moving particle is also tracked under the conditions of knowing its starting position and continuous tracking. Additionally, we discuss its applicability to anisotropic particle detection, and show its potential to distinguish the rotation and spin of the anisotropic particle and measure its rotational velocity and spin speed (magnitude and direction). Our demonstration opens the path to vectorial Doppler metrology for detection of universal motion vectors with vectorially structured light.
Emulation of photonic synapses through photo‐recordable devices has aroused tremendous discussion owing to the low energy consumption, high parallel, and fault‐tolerance in artificial neuromorphic ...networks. Nonvolatile flash‐type photomemory with short photo‐programming time, long‐term storage, and linear plasticity becomes the most promising candidate. Nevertheless, the systematic studies of mechanism behind the charge transfer process in photomemory are limited. Herein, the physical properties of APbBr3 perovskite quantum dots (PQDs) on the photoresponsive characteristics of derived poly(3‐hexylthiophene‐2,5‐diyl) (P3HT)/PQDs‐based photomemory through facile A‐site substitution approach are explored. Benefitting from the lowest valance band maximum and longest exciton lifetime of FAPbBr3 quantum dot (FA‐QDs), P3HT/FA‐QDs‐derived photomemory not only exhibits shortest photoresponsive characteristic time compared to FA0.5Cs0.5PbBr3 quantum dots (Mix‐QDs) and CsPbBr3 quantum dots (Cs‐QDs) but also displays excellent ON/OFF current ratio of 2.2 upon an extremely short illumination duration of 1 ms. Moreover, the device not only achieves linear plasticity of synapses by optical potentiation and electric depression, but also successfully emulates the features of photon synaptic such as pair‐pulse facilitation, long‐term plasticity, and multiple spike‐dependent plasticity and exhibits extremely low energy consumption of 3 × 10−17 J per synaptic event.
Engineering of minimum photo‐recording time in poly(3‐hexylthiophene)/APbBr3 perovskite quantum dots‐based photomemory via facile an A‐site substitution approach is demonstrated. poly(3‐hexylthiophene‐2,5‐diyl)/FAPbBr3 quantum dot‐derived photomemory displays an extremely short programming time of 1 ms and enables the extremely low energy consumption of 3 × 10−17 J per synaptic event on the application of photonic synapse.
Wearable and self‐healing soft electronics have led to a significant emphasis on their potential in creating versatile, conformable, and sustainable electronic modules. Among conductive additives, ...Liquid metals (LMs), combining both solid and liquid characteristics, have gained widespread attention due to their versatile physical, chemical, and electrical properties as well as self‐healing capability, biocompatibility, and recyclability. The fluidity of LMs facilitates adaptability to various experimental conditions and components for specific applications. Moreover, the oxide shell on LMs exhibits strong compatibility with surface functionalization and polymerization processes, enhancing the development of reliable composite materials. Herein, an in‐depth analysis of the fundamental properties and characteristics of LMs while addressing their current drawbacks, such as unpredictable reactivity and poor surface stability, is presented. To harness the advantages of LMs, their integration is extensively discussed with polymeric materials through various grafting strategies, leading to the development of macromolecular composites with exceptional softness, solubility, surface functionalization, and versatility. Furthermore, the applications of LMs within LM‐elastomer composites, particularly focusing on their relevance in specific fields such as flexible electronics, are investigated. Finally, LMs' future prospects are emphasized by highlighting their compatibility with self‐healing polymers, thereby providing pathways for major breakthroughs of LMs based devices.
This review provides valuable insights into liquid metal‐polymer composites and outlines crucial avenues for their continued advancement. The focus is on creating sustainable, self‐healable liquid metal‐polymer composites to achieve enhanced functionality and practical applicability.
Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resistance genes and bacteria. Here we study the impact of confined and controlled swine farm environments on ...temporal changes in the gut microbiome and resistome of veterinary students with occupational exposure for 3 months. By analyzing 16S rRNA and whole metagenome shotgun sequencing data in tandem with culture-based methods, we show that farm exposure shapes the gut microbiome of students, resulting in enrichment of potentially pathogenic taxa and antimicrobial resistance genes. Comparison of students' gut microbiomes and resistomes to farm workers' and environmental samples revealed extensive sharing of resistance genes and bacteria following exposure and after three months of their visit. Notably, antibiotic resistance genes were found in similar genetic contexts in student samples and farm environmental samples. Dynamic Bayesian network modeling predicted that the observed changes partially reverse over a 4-6 month period. Our results indicate that acute changes in a human's living environment can persistently shape their gut microbiota and antibiotic resistome.
Cultural creativity industries are new driving force of regional economic development. Based on 10 specific evaluation index systems, this paper constructs cultural creativity industries variable, ...and uses factor analysis, multiple linear regression and hierarchical regression analysis to analyze 31 provinces (municipalities and autonomous regions) in China. The research shows that: cultural creativity industries have a significant role in promoting regional economic development, economic environment has a positive role in moderating effects, the better economic environment, the more obvious role of regional cultural creativity industries in promoting regional economic development, cultural creativity industries and educational environment have a positive role in promoting regional economic development, education environment has a positive moderating effects, science-technological environment has a positive moderating effects, and the better regional science-technological environment is more conducive to the promotion of cultural creativity industries to regional economic development.
Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by ...pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high‐level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next‐generation tetracyclines, and a basic framework for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large‐scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram‐negative bacteria in both human and veterinary medicine.
The novel mobile tetracycline‐inactivating enzymes, Tet(X3)–Tet(X5), could confer high‐level tigecycline resistance. They have been disseminated in diverse bacterial hosts from a wide range of ecological niches through promiscuous plasmids and ISCR2. This complex dissemination can be driven by selective pressure from the massive use of the early tetracyclines.
PDF
