Cancer is an ancient disease of multi-cellular organisms acquired in the history of evolution. For more than one century, cancer was defined as a disease of autonomous, abnormal growth of cells from ...an organ or tissue. Therefore, the majority of research and resources were focused on the cancer, especially cancer cells. In recent decades, an increasing body of evidence has emerged to indicate that carcinogenesis and cancer progressions involve systemic dysregulation, which may be the important driving force in cancer development as well as its progression. As we have emphasized in Chapter 1, we defined cancer as a systems disease which is characterized by abnormal cell growth in a defined tissue or organ and progressive systemic dysregulation.
Anthracycline chemotherapy remains an integral part of the care for curative intent chemotherapy in breast cancer and non-Hodgkin lymphoma patients. Better tools need to be identified to predict ...cardiac complications of anthracycline chemotherapy.
We investigated the utility of high-sensitivity cardiac troponin T (hscTnT), N-terminal pro-B-type natriuretic peptide, cardiac troponin T and I, and creatine kinase (CK)-MB in cancer patients receiving anthracycline-based chemotherapy, in order to determine whether baseline levels or changes in these biomarkers may help predict the onset of congestive heart failure.
Eighteen consecutive patients with a pathologic diagnosis of breast cancer or non-Hodgkin lymphoma were enrolled. The median dose of doxorubicin exposure was 240 mg/m(2) (range 240-400 mg/m(2)). After treatment with doxorubicin, the hscTnT increased to 19.1 pg/mL (P<0.001). CKMB and N-terminal pro-B-type natriuretic peptide levels increased to 1.1 ng/mL and 88.3 pg/mL, respectively (P=0.02). When subjects who had a decline in left ventricular ejection fraction (LVEF) by equilibrium radionuclide ventriculography were compared to those who did not have a change in LVEF, there was a suggestion that those subjects with an elevated baseline hscTnT were more likely to have a decline in LVEF (2.7 pg/mL and 0.1 pg/mL, respectively; P=0.07). Spearman correlation demonstrated that patients with higher baseline hscTnT and CKMB tended to have a greater decline in LVEF (Spearman correlation -0.54, 95% confidence interval -0.80 to -0.08 P=0.02, and -0.49, 95% confidence interval -0.77 to -0.01 P=0.04, respectively).
Elevations in baseline hscTnT levels are suggestive of an oncology subgroup at high risk of developing cardiac complications from their chemotherapy. Early detection by oncologists with the use of baseline biomarkers may be clinically important in designing interventions to prevent serious anthracycline-based chemotherapy complications.
Progress in Green Tribology Davim, J. Paulo; Hu, Xianghuo; Prasanta, Sahoo ...
2017, 2017-04-10, Volume:
2
eBook
This book is dedicated to new advances in biotribology, tribology in small scale and green tribology. Tribology includes the research and application of principles of friction, wear, lubrication and ...design. As a multidisciplinary field of science and technology, developments in tribology lead to various new products in mechanics, chemistry, electronics, life sciences, and sensors.
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