Marine fisheries and aquaculture can match growing demand for marine protein from an increasing population. However, the microplastics (MPs) in marine environments may pose a threat to human health ...through food chains by seafood consumption. The MPs have been found lodged in the digestive tracts and other tissues of various sea animals, nevertheless, little is known in regard to the accumulation of MPs in fish from major fish farms and mariculture areas, especially in non-digestive tissues of fishes. This study investigated the accumulation of MPs in six major wild fish species (including Thryssa kammalensis, Amblychaeturichthys hexanema, Odontamblyopus rubicundus, Cynoglossus semilaevis, Chaeturichthys stigmatias and Collichthys lucidus), both in digestive and non-digestive tissues, from an important fish farm and mariculture area, Haizhou Bay, China. All fishes had items that were identified as MPs. The highest abundance of MPs was 22.21±1.70items/individual or 11.19±1.28items/g in T. kammalensis, which is filter-feeding and usually inhabits in estuary. The lowest abundance of MPs was observed in C. semilaevis (13.54±2.09items/individual) and C. stigmatias (1.61±0.56items/g). The abundance of MPs exponentially increased with the decrease of MPs size. The MPs were dominated by fiber in shape, black or grey in colour and cellophane in composition. As to different tissues, the total number of MPs on skin (800) or in gills (746) was higher than that in gut (514). In terms of skin, the abundances of MPs in three species of scaleless fish with mucus (A. hexanema, C. stigmatias and O. rubicundus) were generally higher than other three fishes with scales (C. lucidus, C. semilaevis and T. kammalensis), implying the potential high risk of scaleless fish consumption for human health in Haizhou Bay. More in-depth studies need to focus on the scaleless fish through mucus adsorbing enormous MPs.
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•All fish in the Haizhou Bay had high microplastic (MP) abundance.•The total number of MPs in skin or in gills was higher than in gut.•The abundance of MPs exponentially increased with the decrease of MPs size.•Scaleless fish had higher MPs abundance in skin than scaly fish.
•Sedimentary PAHs in Guan River Estuary were investigated for the first time.•PAH concentrations were low in comparison with other estuaries around the world.•PAH concentrations appeared to be ...negatively correlated with sediment grain size.•Sedimentary PAHs in GRE mainly originated from pyrolytic sources.•Sedimentary PAHs in GRE indicated low negative effects except FLO.
The contamination of surface sediments in Guan River Estuary, China, by polycyclic aromatic hydrocarbons (PAHs) has been fully investigated. Total concentrations of 21 PAHs ranged from 90 to 218ng/g with an average of 132.7ng/g, which is relatively low in comparison with other estuaries around the world. PAH concentrations appeared to be positively correlated with clay content and negatively correlated with sediment grain size. Source identification implied that the PAHs originated mainly from pyrolytic sources. However, source patterns may be continuously changed to a petrogenic origin due to the heavy ship traffic and continuous discharge of oily sewage in this area. The PAH levels were also compared with international Sediments Quality Guidelines and Sediments Quality Criteria, and the results indicated low negative effects for most individual PAHs. However, toxic effects related to FLO would occur occasionally in most locations in the estuary.
As both social network structure and strength of influence between individuals evolve constantly, it requires tracking the influential nodes under a dynamic setting. To address this problem, we ...explore the Influential Node Tracking (INT) problem as an extension to the traditional Influence Maximization problem (IM) under dynamic social networks. While the Influence Maximization problem aims at identifying a set of k nodes to maximize the joint influence under one static network, the INT problem focuses on tracking a set of influential nodes that keeps maximizing the influence as the network evolves. Utilizing the smoothness of the evolution of the network structure, we propose an efficient algorithm, Upper Bound Interchange Greedy (UBI) and a variant, UBI+. Instead of constructing the seed set from the ground, we start from the influential seed set we found previously and implement node replacement to improve the influence coverage. Furthermore, by using a fast update method by calculating the marginal gain of nodes, our algorithm can scale to dynamic social networks with millions of nodes. Empirical experiments on three real large-scale dynamic social networks show that our UBI and its variants, UBI+ achieves better performance in terms of both influence coverage and running time.
Spontaneous functional recovery occurs during the acute phase after stroke onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism underlying spontaneous recovery and ...identifying potential strategies to promote functional rehabilitation after stroke are very important. The CD200/CD200R signaling pathway plays an important role in neurological recovery by modulating synaptic plasticity during multiple brain disorders. However, the effect and mechanism of action of the CD200/CD200R pathway in spontaneous functional recovery after stroke are unclear.
In this study, we used a transient middle cerebral artery occlusion (MCAO) model in rats to investigate the function of CD200/CD200R signaling in spontaneous functional recovery after stroke. We performed a battery of behavioral tests (Longa test, adhesive removal test, limb-use asymmetry test, and the modified grip-traction test) to evaluate sensorimotor function after intracerebroventricular (i.c.v.) injection with CD200 fusion protein (CD200Fc) or CD200R blocking antibody (CD200R Ab) post-stroke. Density and morphology of dendritic spines were analyzed by Golgi staining. Microglia activation was evaluated by immunofluorescence staining. Western blot was used to detect the levels of protein and the levels of mRNA were measured by qPCR.
Our study demonstrated that sensorimotor function, synaptic proteins, and structures were gradually recovered and CD200R was transiently upregulated in ipsilateral cortex after stroke. Synapse-related proteins and dendritic spines were preserved, accompanied by sensorimotor functional recovery, after stereotaxic CD200Fc injection post-stroke. In addition, CD200Fc restrained microglia activation and pro-inflammatory factor release (such as Il-1, Tnf-α, and Il-6) after MCAO. On the contrary, CD200R Ab aggravated sensory function recovery in adhesive removal test and further promoted microglia activation and pro-inflammatory factor release (such as Il-1) after MCAO. The immune-modulatory effect of CD200/CD200R signaling might be exerted partly by its inhibition of the MAPK pathway.
This study provides evidence that the CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity via inhibition of microglia activation and inflammatory factor release.
Mental health imbalance are the main cause of anxiety, depression and happiness reduction in the older. Self-assessment living standard and sleep quality are both influencing factors of mental ...health. Meantime, self-assessment living standard has an impact on sleep quality. But there's no research on the relationship between the three, we conducted this study to explore the relationship between self-assessment living standard and mental health and the mediating role of sleep quality among the older in rural areas of China.
Using typical field sampling method, M County, Anhui Province was selected as the investigation site, and a total of 1223 respondents were selected. With the help of questionnaires enclosing respondents' sociodemographics information, 12 Items General Health Questionnaire (GHQ-12) and Pittsburgh Sleep Quality Scale (PSQI), face-to-face interviews were used to collect data. Bootstrap test was used for data analysis.
The results showed that the age of the respondents ranged from 60 to 99 years, with an average age of (66.53 ± 6.77) years, the proportion of the older with a tendency to mental health problems was 24.7%. Most of the older people's self-assessment living standard was normal (average score was 2.89 ± 0.726), accounting for 59.3% of the total. The average sleep quality score was (6.97 ± 4.066), and 2.5% of the respondents reported serious sleep problems. older with low self- assessment living standards were more likely to report a higher propensity for psychological problems (β = 0.420, P < 0.001) and poorer sleep quality (β = 0.608, P < 0.001) than older with high self- assessment living standards. Mental health of the older may be related to sleep quality (β = 0.117, P < 0.001). In addition, the effect of self- assessment living standard on mental health was significantly mediated by sleep quality (β = 0.071, P < 0.001).
Mental health is associated with self-assessment living standard, with this association mediated by sleep quality. A reasonable mechanism needs to be established to improve self-assessment living standard and sleep quality.
We aimed to explore the correlation between functional disability and quality of life (QoL). And exploring the interaction of functional disability, basic demographic characteristics and ...health-related information on QoL among the rural elderly in Anhui Province.
This study used multi-stage stratified cluster sampling in rural Anhui Province from January to July 2018 to conduct a cross-sectional survey of older adults who met the inclusion criteria. The Five-Dimensional European Quality Of Health Scale (EQ-5D) and the WHO Disability Assessment Schedule (WHODAS2.0) scale were used to evaluate the QoL and functional disability, and the basic demographic characteristics of the survey subjects were also collected. Using binary logistic and Classification and regression tree model (CART) models to analyze the data, explore the relationship between functional disability and QoL in the elderly.
A total of 3491 older adults were included in the survey, and 3336 completed the entire survey, with an effective response rate of 95.56%. After adjusting for covariables, those who had limited in dimension of mobility (AOR=2.243, 95%CI: 1.743-2.885), getting along (AOR=1.615, 95%CI: 1.173-2.226), life activities (AOR=2.494, 95%CI:1.928-3.226), and social participation (AOR=2.218, 95%CI: 1.656-2.971) had a lower QoL. However, the dimension of cognition (AOR=0.477, 95%CI: 0.372-0.613) is a protective factor for QoL. Additionally, we also observe that 96.3% of those who were unemployed and limited in both mobility and life activities dimensions had a lower QoL, but among those who were robust in both mobility and social participation dimensions and not suffer from chronic diseases, 56.3% had a higher QoL.
Our findings indicate that special attention should be paid to the elderly who are unemployed, have limited in cognition, getting along, social participation, mobility, life activities and cognition robust to improve their QoL. This research is of great significance for formulating targeted strategies and measures to improve the QoL for rural elderly.
The disruption of the blood–brain barrier (BBB) plays a critical role in the pathology of ischemic stroke. p75 neurotrophin receptor (p75NTR) contributes to the disruption of the blood‐retinal ...barrier in retinal ischemia. However, whether p75NTR influences the BBB permeability after acute cerebral ischemia remains unknown. The present study investigated the role and underlying mechanism of p75NTR on BBB integrity in an ischemic stroke mouse model, middle cerebral artery occlusion (MCAO). After 24 h of MCAO, astrocytes and endothelial cells in the infarct‐affected brain area up‐regulated p75NTR. Genetic p75NTR knockdown (p75NTR+/−) or pharmacological inhibition of p75NTR using LM11A‐31, a selective inhibitor of p75NTR, both attenuated brain damage and BBB leakage in MCAO mice. Astrocyte‐specific conditional knockdown of p75NTR mediated with an adeno‐associated virus significantly ameliorated BBB disruption and brain tissue damage, as well as the neurological functions after stroke. Further molecular biological examinations indicated that astrocytic p75NTR activated NF‐κB and HIF‐1α signals, which upregulated the expression of MMP‐9 and vascular endothelial growth factor (VEGF), subsequently leading to tight junction degradation after ischemia. As a result, increased leukocyte infiltration and microglia activation exacerbated brain injury after stroke. Overall, our results provide novel insight into the role of astrocytic p75NTR in BBB disruption after acute cerebral ischemia. The p75NTR may therefore be a potential therapeutic target for the treatment of ischemic stroke.
Main Points
Cerebral ischemia triggers astrocytic p75NTR upregulation, promoting neuroinflammation via NF‐κB and HIF‐1α pathways to increase BBB disruption.
Genetic/pharmacological inhibition of p75NTR ameliorates ischemic brain injury including BBB damage.
The global environmental concern has promoted the installed capacity of renewable energy to explode. The uncertainty of the growing renewable energy poses a risk of incorrect forecasting of clearing ...prices and misled strategies to participants in the deregulated power markets. However, the transmission loss and the correlation among integrated wind power outputs are ignored in the existing research. To improve the forecasting accuracy, this paper presents a Markov Chain Monte Carlo method for stochastic LMP considering the correlation among wind power outputs and transmission loss. The expectation of an LMP with a given precision can be obtained from the proposed method. The case study verifies the validity of the proposed method, demonstrating that the squared Euclidean distance of the selected Archimedean Copula function is limited to 9.3143. Additionally, given the same convergence criteria, the sampling times are reduced by an order of magnitude compared to the Acceptance-Rejection sampling method.
The energetic electrons in the Earth’s radiation belt, known as “killer electrons”, are one of the crucial factors for the safety of geostationary satellites. Geostationary satellites at different ...longitudes encounter different energetic electron environments. However, organizations of space weather prediction usually only display the real-time ≥2 MeV electron fluxes and the predictions of ≥2 MeV electron fluxes or daily fluences within the next 1–3 days by models at one location in GEO orbit. In this study, the relationship of ≥2 MeV electron fluxes at different longitudes is investigated based on observations from GOES satellites, and the relevant models are developed. Based on the observations from GOES-10 and GOES-12 after calibration verification, the ratios of the ≥2 MeV electron daily fluences at 135° W to those at 75° W are mainly in the range from 1.0 to 4.0, with an average of 1.92. The models with various combinations of two or three input parameters are developed by the fully connected neural network for the relationship between ≥2 MeV electron fluxes at 135° W and 75° W in GEO orbit. According to the prediction efficiency (PE), the model only using log10 (fluxes) and MLT from GOES-10 (135° W), whose PE can reach 0.920, has the best performance to predict ≥2 MeV electron fluxes at the locations of GOES-12 (75° W). Its PE is larger than that (0.882) of the linear model using log10 (fluxes four hours ahead) from GOES-10 (135° W). We also develop models for the relationship between ≥2 MeV electron fluxes at 75° W and at variable longitudes between 95.8° W and 114.9° W in GEO orbit by the fully connected neural network. The PE values of these models are larger than 0.90. These models realize the predictions of ≥2 MeV electron fluxes at arbitrary longitude between 95.8° W and 114.9° W in GEO orbit.
Abstract
We studied the influence of temperature and pressure on the surface morphology and V-defects of the InGaN films. It was found that an appropriate increase in the growth temperature enhanced ...the mobility of Ga and In atoms, smoothened the surface of the InGaN thin film samples, and improved the growth quality. Simultaneously, increasing the temperature appropriately reduced the surface roughness of the sample and the defect density of the V-defects. It is also found that under the same temperature conditions, a lower pressure weakens the incorporation barrier of atoms, enhances the incorporation efficiency of In atoms, and improves the growth quality of InGaN.
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