In recent research activities, autonomous vehicles and self-driving technology have gained lot of attention among scientists. The idea of autonomous vehicles can be anticipated in the 1920s when the ...design of the first radio-controlled vehicles was in progress. Autonomous vehicles are going to be the trend of the future in this modern era of automation and technology. In this paper various autonomous driving aspects, highlighting the software stack and hardware components are discussed. The software architecture covers mainly robot operating system (ROS), machine learning (ML), deep learning (DL), and OpenCV frameworks, along with the calibration of sensors and cameras. The paper also discussed about simultaneous localization and mapping (SLAM) based-path tracking, computer vision-based controller, and intelligent object avoidance. Further, point cloud, ground, radius, and raycast filters was implemented to distinguish between the real-time objects, ground, and its own parts or obstacle shadows. The paper highlights the overall hardware modules responsible for controlling the car.
•Future trend of Autonomous vehicles in modern era of automation and technology.•Simultaneous localization and mapping based-path tracking.•Computer vision-based controller, and intelligent object avoidance.•Discussion on Hardware modules responsible for controlling the car.
The aim of the study was to find a role of Curcumin from natural source to overcome drug resistance as well as to reduce cytotoxicity profile of the drug in Acute Myeloid Leukemia patients.
Primary ...leukemic cells were obtained from AML patient's bone marrow. These cells were then exposed to different concentration of cytarabine and curcumin to find out IC50 values and also its effect on MDR genes like MDR1, BCRP, LRP and FLT3 by RT-PCR method.
Our results suggested that curcumin down regulates MDR genes. Gene expression was decreased by 35.75, 31.30, 27.97 % for MDR1, LRP, BCRP respectively. In FLT3, it was 65.86 % for wild type and 31.79 % for FLT3-ITD. In addition to this, curcumin has also shown anti-proliferative effect as well as synergistic effect in combination with Cytarabine on primary leukemic cells. Thus, we can conclude that curcumin can be used as MDR modulator as well as chemosensitizer in combination with cytarabine, standard chemotherapeutic drug, to reduce the cytotoxicity profile as IC50 value decreases when treated in combination.
Background: Osteoarthritis (OA) is a chronic, non-inflammatory, degenerative joint disease with Knee OA being the most prevalent one with main factor of disability among middle-aged and older people ...worldwide. Age and repetitive mechanical loads being the main causative factors, it shows pain Knee range to be painful. Techniques like IFT and wet packs, physiotherapy seeks to reduce signs and symptoms including pain and oedema. Non-weight-bearing muscle-strengthening exercises have been shown to be useful. Methodology: A Case series was carried out by the Interns on Patients having osteoarthritis of knee who visited Physiotherapy OPD, Dhiraj Hospital, with a minimal sample size of 5 cases, for the study duration of 3 Months. The Inclusion Criteria for the study were: Both Male and Female patients with Age 40-70 years, Patients diagnosed with Unilateral/bilateral OA knee, willing to perform physical therapy exercise, having Kellgren-Lawrence Grade 1 & 2 graded by radiologist. Outcome Measures used were: Numeric Pain Rating Scale, Western Ontario and McMaster universities arthritis index (WOMAC), Repetition Maximum (RM), Goniometery. Result: The results showed decrease in pain, Increase ROM of knee ranges, improve strength of the muscles and better functional performance Conclusion: It was observed that Physiotherapy improved knee range of motion, muscle strength, pain and physical function in patient with osteoarthritis of knee.
