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  • Preparing intensive care fo... Preparing intensive care for the next pandemic influenza
    Kain, Taylor; Fowler, Robert Critical care (London, England), 10/2019, Volume: 23, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Few viruses have shaped the course of human history more than influenza viruses. A century since the 1918-1919 Spanish influenza pandemic-the largest and deadliest influenza pandemic in recorded ...
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  • Validation of sTREM-1 and I... Validation of sTREM-1 and IL-6 based algorithms for outcome prediction of COVID-19
    Van Singer, Mathias; Brahier, Thomas; Koch, Jana ... BMC infectious diseases, 09/2023, Volume: 23, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    A prospective observational cohort study of COVID-19 patients in a single Emergency Department (ED) showed that sTREM-1- and IL-6-based algorithms were highly predictive of adverse outcome (Van ...
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  • Glucagon-Like Peptide-1 Rec... Glucagon-Like Peptide-1 Receptor Activation Inhibits Growth and Augments Apoptosis in Murine CT26 Colon Cancer Cells
    Koehler, Jacqueline A; Kain, Taylor; Drucker, Daniel J Endocrinology, 09/2011, Volume: 152, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Obesity, accompanying or independent of type 2 diabetes mellitus (T2DM), is associated with higher rates of malignancy. Hence, there is considerable interest in understanding whether therapies used ...
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  • Sigmoid Th17 populations, t... Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy
    Chege, Duncan; Sheth, Prameet M; Kain, Taylor ... AIDS, 03/2011, Volume: 25, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Th17 cells play an important role in mucosal defence and repair and are highly susceptible to infection by HIV. Antiretroviral therapy (ART) suppresses HIV viremia and can restore CD4(+) numbers in ...
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  • Pharmacologic Treatments an... Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome
    Kain, Taylor; Lindsay, Patrick J; Adhikari, Neill K J ... Emerging infectious diseases 26, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). We conducted a systematic review of evidence ...
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  • Blunted IL17/IL22 and pro-i... Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in Kenya
    Chege, Duncan; Chai, Yijie; Huibner, Sanja ... PloS one, 08/2012, Volume: 7, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. ...
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  • The "wing-heeled" traveler The "wing-heeled" traveler
    Kain, Taylor; Weinstein, Jordan; Thompson, Aaron ... Tropical diseases, travel medicine and vaccines, 02/2020, Volume: 6, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Intoxication syndromes may be travel acquired, and are related to intentional or accidental inhalational or percutaneous exposures or ingestions. Due to their myriad clinical presentations, initial ...
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  • Use of an HIV‐risk screenin... Use of an HIV‐risk screening tool to identify optimal candidates for PrEP scale‐up among men who have sex with men in Toronto, Canada: disconnect between objective and subjective HIV risk
    Wilton, James; Kain, Taylor; Fowler, Shawn ... Journal of the International AIDS Society, January 2016, Volume: 19, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Introduction Identifying appropriate pre‐exposure prophylaxis (PrEP) candidates is a challenge in planning for the safe and effective roll‐out of this strategy. We explored the use of a validated HIV ...
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  • Murine Plasmodium chabaudi ... Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae
    Chege, Duncan; Higgins, Sarah J; McDonald, Chloe R ... Journal of acquired immune deficiency syndromes, 2014-Apr-15, Volume: 65, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    To evaluate if systemic murine malarial infection enhances HIV susceptibility through parasite-induced mucosal immune alterations at sites of HIV sexual exposure. Malaria and HIV have a high degree ...
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