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  • Orm protein phosphoregulati... Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways
    Sun, Yidi; Miao, Yansong; Yamane, Yukari ... Molecular biology of the cell, 06/2012, Volume: 23, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Sphingoid intermediates accumulate in response to a variety of stresses, including heat, and trigger cellular responses. However, the mechanism by which stress affects sphingolipid biosynthesis has ...
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  • N-Glycolylneuraminic Acid D... N-Glycolylneuraminic Acid Deficiency in Mice: Implications for Human Biology and Evolution
    Hedlund, Maria; Tangvoranuntakul, Pam; Takematsu, Hiromu ... Molecular and Cellular Biology, 06/2007, Volume: 27, Issue: 12
    Journal Article
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    Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue ...
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  • Germinal Center Marker GL7 ... Germinal Center Marker GL7 Probes Activation-Dependent Repression of N-Glycolylneuraminic Acid, a Sialic Acid Species Involved in the Negative Modulation of B-Cell Activation
    Naito, Yuko; Takematsu, Hiromu; Koyama, Susumu ... Molecular and Cellular Biology, 04/2007, Volume: 27, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue ...
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4.
  • CD22 serves as a receptor f... CD22 serves as a receptor for soluble IgM
    Adachi, Takahiro; Harumiya, Satoru; Takematsu, Hiromu ... European journal of immunology, January 2012, Volume: 42, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    CD22 (Siglec‐2) is a B‐cell membrane‐bound lectin that recognizes glycan ligands containing α2,6‐linked sialic acid (α2,6Sia) and negatively regulates signaling through the B‐cell Ag receptor (BCR). ...
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  • Psychosine-triggered endomi... Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow
    Watanabe, Hiroshi; Okahara, Kyohei; Naito-Matsui, Yuko ... Molecular biology of the cell, 07/2016, Volume: 27, Issue: 13
    Journal Article
    Peer reviewed
    Open access

    Endomitosis is a special type of mitosis in which only cytokinesis-the final step of the cell division cycle-is defective, resulting in polyploid cells. Although endomitosis is biologically ...
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  • Hypoxia Induces Adhesion Mo... Hypoxia Induces Adhesion Molecules on Cancer Cells: A Missing Link between Warburg Effect and Induction of Selectin-Ligand Carbohydrates
    Koike, Tetsufumi; Kimura, Naoko; Miyazaki, Keiko ... Proceedings of the National Academy of Sciences - PNAS, 05/2004, Volume: 101, Issue: 21
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    Peer reviewed
    Open access

    Cancer cells undergo distinct metabolic changes to cope with their hypoxic environment. These changes are achieved at least partly by the action of transcriptional factors called hypoxia-inducible ...
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  • Hypoxic culture induces exp... Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells
    Yin, Jun; Hashimoto, Ayako; Izawa, Mineko ... Cancer research (Chicago, Ill.), 03/2006, Volume: 66, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Tumor hypoxia figures heavily in malignant progression by altering the intracellular glucose metabolism and inducing angiogenic factor production, thus, selecting and expanding more aggressive cancer ...
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  • Human B-lymphocytes Express... Human B-lymphocytes Express α2-6-Sialylated 6-Sulfo-N-acetyllactosamine Serving as a Preferred Ligand for CD22/Siglec-2
    Kimura, Naoko; Ohmori, Katsuyuki; Miyazaki, Keiko ... The Journal of biological chemistry, 11/2007, Volume: 282, Issue: 44
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    Peer reviewed
    Open access

    CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize α2-6-sialylated glycan as a specific ligand. Here we propose that the α2-6-sialylated and 6-GlcNAc-sulfated ...
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  • Anomalous expression of Thy... Anomalous expression of Thy1 (CD90) in B-cell lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment
    Ishiura, Yoshihito; Kotani, Norihiro; Yamashita, Ryusuke ... Biochemical and biophysical research communications, 05/2010, Volume: 396, Issue: 2
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    Peer reviewed

    The anti-CD20 monoclonal antibody (Ab) rituximab is accepted to be an effective therapeutic Ab for malignant B-cell lymphoma; however, discovery of other cell surface antigens is required for the ...
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  • Physical and Functional Ass... Physical and Functional Association of Glucuronyltransferases and Sulfotransferase Involved in HNK-1 Biosynthesis
    Kizuka, Yasuhiko; Matsui, Takahiro; Takematsu, Hiromu ... The Journal of biological chemistry, 05/2006, Volume: 281, Issue: 19
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    Peer reviewed
    Open access

    HNK-1 carbohydrate expressed predominantly in the nervous system is considered to be involved in cell migration, recognition, adhesion, and synaptic plasticity. Human natural killer-1 (HNK-1) ...
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