Primary cilia are a component of almost all vertebrate cells with a crucial role in sensing and transducing environmental signals during tissue development. Their dysfunction is known as ciliopathies ...and can manifest with a wide spectrum of clinical disorders. Overlapping features and molecular heterogeneity of ciliopathies make diagnoses distinctly challenging. In this group of diseases, tectonic genes, and their mutations play an important role. We present a first-trimester fetus with occipital encephalocele and OFD type IV caused by TCTN3 compound heterozygous pathogenic variants: c.1423_1429del (p.Arg475Serfs*10) and c.3G>A (initiator codon). A severe arm anomaly was described in our case, with two fingers along the atrophic forearm and polydactyly on other limbs. This could be a new phenotypic characteristic contributing to further understanding of TCTN3-related disorders as well as other tectonic proteins in ciliopathy spectrum diseases.
TREBAMO LI POVEĆATI BROJ CARSKIH REZOVA? Tadić, Edita; Štefanić-Mitrović, Danijela; Milić, Nikša ...
Gynaecologia et perinatologia,
03/2003, Volume:
12, Issue:
1
Paper
Open access
Cilj rada. Sa svrhom da se ustanovi postoji li u rodilištu Opće bolnice Zadar objektivni razlog za povećanje broja carskih rezova, obrađeni su za razdoblje od 1997.–2001. g. (8479 poroda) perinatalni ...mortalitet i stanje djece po porodu (Apgar zbroj u 1. i 5. min., klinički i laboratorijski znakovi asfiksije, te UZV glave), posebno djece rođene vaginalno, a posebno one rođene carskim rezom. Posebno su obrađeni porodi u stavu zatkom, stanja nakon prethodnog carskog reza, te blizanačka trudnoća. Rezultati. Broj carskih rezova kretao se po godinama otprilike podjednako (6,3–7,79%), prosječno 7,26%. Perinatalni mortalitet pokazivao je veće razlike, tj. od 10,18–3‰ (prosječno 6,73‰). Perinatalni mortalitet djece rođene vaginalno iznosio je 6,02‰, a djece rođene carskim rezom 15,70‰ (t=2,81). Najveći dio perinatalno umrle djece odnosi se na fetalnu smrt. Rani neonatalni mortalitet djece rođene vaginalno iznosio je 2,55‰, a djece rođene carskim rezom 9,47‰ (t=3,12), s tim da je 64% rano neonatalno umrle djece bilo nedonošeno. Vrijednost Apgar zbroja <7 u 1. min. bile su u 1,1% djece rođene vaginalno i u 25,7% djece rođene carskim rezom (t=35,27). Apgar zbroj <7 u 5. min. imalo je 0,48% djece rođene vaginalno i 13,4% djece rođene carskim rezom (t=11,59). Dijagnoza hipoksije postavljena je u 0,88% djece rođene vaginalno, a u 25,37% djece porođene carskim rezom (t=36,49). Zaključak. Proizlazi da u zadarskoj bolnici ne postoji objektivan razlog za znatnije povećanje broja carskih rezova, posebice ne u smislu liberalizacije.
Anaerobic digestion (AD) is already contributing to global climate change efforts both from feedstock and end-use side but there is still room for an improvement. Digestate is a by-product of AD ...process that has been neglected during the 2000s and beyond biogas market uptake in the EU. In areas densely populated with AD plants, the same challenges occur as intensive livestock production: feedstock for AD process and lack of available land for nutrient application, in compliance with the good agriculture practice. If digestate is to become a storable fertilizer, it could also replace fossil-based fertilizer and add to GHG emission savings. This paper examines a viability of thermo-chemical digestate treatment to utilize it as feedstock in the AD process by crystalizing nutrients from digestate to allow long distance nutrient application. Digestate was treated with thermo-chemical treatment, consisted of mostly components (heat, sulphur) available on site. The treatment proved the degradation of lignocellulosic walls, allowing more access of bacteria to monosaccharides concentrations, i.e. sugars, but nutrients crystallization also occurred, producing struvite and β-calcium phosphate tetrahydrate. Treated digestate was re-circulated in AD to record an increase in methane concentrations by 3–5 vol%, compared to conventional mixtures. The results lay foundation for further research in GHG emission savings from digestate, improved nutrient cycle and digestate management as well as potential in improvement of economic feasibility of an AD plant by expanding the feedstock base to locally available plant materials with tighter lignocellulosic bonds.
This paper presents a method for stator resistance identification of an induction motor in an indirect rotor field-oriented control system. This method is based on a simple artificial neural network, ...in which the rotor time constant is no longer considered to be a constant parameter, but is instead identified using an adaptive model reference system-based procedure. The neural network outputs the estimated rotor speed. The difference between the actual and the estimated rotor speed is used as a signal for either manual or automated fuzzy logic stator resistance identification. Simulations and experiments show the effectiveness of the described approach.
This paper presents an ANN-based (artificial neural network-based) method of stator resistance tuning in an IRFO (indirect rotor field oriented) control system of an induction motor. This method is ...based on the conventional two-layer ANN in which the rotor time constant is not a constant parameter and is identified using a model reference adaptive system (MRAS) - based procedure. During the training, rotor speed estimation of the induction motor is enabled. The difference between the actual and the estimated rotor speed is used as a signal for manual stator resistance tuning. Computer simulations and experimental results show the effectiveness of the described approach in a low rotor speed region.
