We provide a comprehensive review of major developments in our understanding of gamma-ray bursts, with particular focus on the discoveries made within the last fifteen years when their true nature ...was uncovered. We describe the observational properties of photons from the radio to 100s GeV bands, both in the prompt emission and the afterglow phases. Mechanisms for the generation of these photons in GRBs are discussed and confronted with observations to shed light on the physical properties of these explosions, their progenitor stars and the surrounding medium. After presenting observational evidence that a powerful, collimated, jet moving at close to the speed of light is produced in these explosions, we describe our current understanding regarding the generation, acceleration, and dissipation of the jet. We discuss mounting observational evidence that long duration GRBs are produced when massive stars die, and that at least some short duration bursts are associated with old, roughly solar mass, compact stars. The question of whether a black-hole or a strongly magnetized, rapidly rotating neutron star is produced in these explosions is also discussed. We provide a brief summary of what we have learned about relativistic collisionless shocks and particle acceleration from GRB afterglow studies, and discuss the current understanding of radiation mechanism during the prompt emission phase. We discuss theoretical predictions of possible high-energy neutrino emission from GRBs and the current observational constraints. Finally, we discuss how these explosions may be used to study cosmology, e.g. star formation, metal enrichment, reionization history, as well as the formation of first stars and galaxies in the universe.
Abstract
Recent observations show that fast radio bursts (FRBs) are energetic but probably non-catastrophic events occurring at cosmological distances. The properties of their progenitors are largely ...unknown in spite of many attempts to determine them using the event rate, duration, and energetics. Understanding the radiation mechanism for FRBs should provide the missing insights regarding their progenitors, which is investigated in this paper. The high brightness temperatures (≳1035 K) of FRBs mean that the emission process must be coherent. Two general classes of coherent radiation mechanisms are considered – maser and the antenna mechanism. We use the observed properties of the repeater FRB 121102 to constrain the plasma conditions needed for these two mechanisms. We have looked into a wide variety of maser mechanisms operating in either vacuum or plasma and find that none of them can explain the high luminosity of FRBs without invoking unrealistic or fine-tuned plasma conditions. The most favourable mechanism is antenna curvature emission by coherent charge bunches where the burst is powered by magnetic reconnection near the surface of a magnetar (B ≳ 1014 G). We show that the plasma in the twisted magnetosphere of a magnetar may be clumpy due to two-stream instability. When magnetic reconnection occurs, the pre-existing density clumps may provide charge bunches for the antenna mechanism to operate. This model should be applicable to all FRBs that have multiple outbursts like FRB 121102.
ABSTRACT
We present a model for fast radio bursts (FRBs) where a large-amplitude Alfvén wave packet is launched by a disturbance near the surface of a magnetar, and a substantial fraction of the wave ...energy is converted to coherent radio waves at a distance of a few tens of neutron star radii. The wave amplitude at the magnetar surface should be about 1011 G in order to produce an FRB of isotropic luminosity 1044 erg s−1. An electric current along the static magnetic field is required by Alfvén waves with non-zero component of transverse wave vector. The current is supplied by counter-streaming electron–positron pairs, which have to move at nearly the speed of light at larger radii as the plasma density decreases with distance from the magnetar surface. The counter-streaming pairs are subject to two-stream instability, which leads to formation of particle bunches of size of the order of c/ωp, where ωp is the plasma frequency. A strong electric field develops along the static magnetic field when the wave packet arrives at a radius where electron–positron density is insufficient to supply the current required by the wave. The electric field accelerates particle bunches along the curved magnetic field lines, and that produces the coherent FRB radiation. We provide a number of predictions of this model.
TB continues to be one of the major public health threats. BCG is the only available vaccine against TB and confers significant protection against the childhood disease. However, the protective ...efficacy of BCG against adult pulmonary TB, which represents a larger burden of disease, is highly variable. It has been suggested that prior exposure to environmental mycobacteria (EMb) mitigates the anti-TB efficacy of BCG by blocking its duplication or masking its immunogenicity. However, its effectiveness against childhood TB and failure of repeated administration to provide additional benefit against pulmonary TB, suggest of some other mechanisms for the variable efficacy of BCG against the pulmonary disease. Importantly, TB is a heterogeneous disease occurring in different forms and having distinct mechanisms of pathogenesis. While inability of the immune system to contain the bacilli is responsible for TB pathogenesis in infants, an aggravated immune response to
has been blamed for the development of adult pulmonary TB. Available data suggest that EMb play a key role in heightening the immune response against
. In this article, differential efficacy of BCG against childhood and adult TB is explained by taking into account the heterogeneity of TB, mechanisms of TB pathogenesis, and the effect of EMb on anti-
immunity. It is believed that a refined understanding of the success and failure of BCG will help in the development of effective anti-TB vaccines.
Polyphenols are the known group of phytochemicals that essentially consists of phenolic rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites perform ...a protective function in plants from environmental and biological stress. When consumed as a human diet these are also known to prevent various age-associated diseases. Polyphenols are known to possess antioxidant properties and protect against oxidative stress. The literature survey was carried out using databases such as PubMed, Science direct and Springer. The research articles from last 10-12 years were selected for this review based on its relevancy with the topic. The articles selected was mainly focused on quercetin and its health benefits. The present review highlights the main functions of a flavonoid, quercetin. Quercetin is among the widely occurring polyphenol, found abundantly in nature. It is commonly present in different plant products. Onion is known to have the highest quantity of quercetin. This plant compound is possessed antioxidant properties and is considered to have a protective function against aging. It is known to be present in both free and conjugated forms. Quercetin has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties. The molecule is lipophilic and can easily cross the BBB (Blood-Brain Barrier) and hence protects from neurodegenerative diseases. Various in vivo and in vitro studies have demonstrated the role of quercetin and here a detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out. Studies have proved that quercetin plays a crucial role in the prevention of age-related disorders. Quercetin is a potent antioxidant which is currently being used in various pharmaceuticals. Properties of quercetin can be further explored in various other disorders. Nanoformulations and liposomal formulations of quercetin can be made to treat other age associated diseases.
ABSTRACT
The discovery of a fast radio burst (FRB) in our Galaxy associated with a magnetar (neutron star with strong magnetic field) has provided a critical piece of information to help us finally ...understand these enigmatic transients. We show that the volumetric rate of Galactic-FRB like events is consistent with the faint end of the cosmological FRB rate, and hence they most likely belong to the same class of transients. The Galactic FRB had an accompanying X-ray burst, but many X-ray bursts from the same object had no radio counterpart. Their relative rates suggest that for every FRB there are roughly 102–103 X-ray bursts. The radio light curve of the Galactic FRB had two spikes, separated by 30 ms in the 400–800 MHz frequency band. This is an important clue and highly constraining of the class of models where the radio emission is produced outside the light cylinder of the magnetar. We suggest that magnetic disturbances close to the magnetar surface propagate to a distance of a few tens of neutron star radii where they damp and produce radio emission. The coincident hard X-ray spikes associated with the two FRB pulses seen in this burst and the flux ratio between the two frequency bands can be understood in this scenario. This model provides a unified picture for faint bursts like the Galactic FRB as well as the bright events seen at cosmological distances.
Abstract
We use the observed properties of fast radio bursts (FRBs) and a number of general physical considerations to provide a broad-brush model for the physical properties of FRB sources and the ...radiation mechanism. We show that the magnetic field in the source region should be at least 1014 G. This strong field is required to ensure that the electrons have sufficiently high ground state Landau energy so that particle collisions, instabilities and strong electromagnetic fields associated with the FRB radiation do not perturb electrons’ motion in the direction transverse to the magnetic field and destroy their coherent motion; coherence is required by the high observed brightness temperature of FRB radiation. The electric field in the source region required to sustain particle motion for a wave period is estimated to be of the order of 1011 esu. These requirements suggest that FRBs are produced near the surface of magnetars perhaps via forced reconnection of magnetic fields to produce episodic, repeated, outbursts. The beaming-corrected energy release in these bursts is estimated to be about 1036 erg, whereas the total energy in the magnetic field is at least ∼1045 erg. We provide a number of predictions for this model which can be tested by future observations. One of which is that short duration FRB-like bursts should exist at much higher frequencies, possibly up to optical.
For the majority of tidal disruption event (TDE) candidates, the observed energy in the optical/near-UV bands is of order 1051 erg. We show that this observed energy is smaller than the minimum ...bolometric energy for the radiative inefficient accretion flow model by a factor of 10-100. We argue that this discrepancy is because the majority of the energy released is in the extreme-UV (EUV) band and/or in the form of relativistic jets beamed away from the Earth. The EUV scenario is supported by existing mid-infrared data and should be further tested by future dust reverberation observations. The jet scenario is disfavored by radio observations of ASASSN-14li but may still be viable for other TDE candidates. We also provide evidence that, at least for some TDEs, most of the missing energy (in the EUV and/or in the form of jets) is released within a few times the orbital period of the most tightly bound material Pmin, which means (1) the circularization of the fallback stream may occur rapidly and (2) the luminosity of the accretion flow or the jet power may not be capped near the Eddington level when the fallback rate is super-Eddington. For most other TDEs, this energy-release timescale is currently not strongly constrained.
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