In this brief, pinning control design for the stabilization of Boolean network (BN) is addressed. Using the semitensor product of matrices, transition matrix of the BN can be obtained. We achieve ...global stability to the fixed point or the elementary cycle for the BN by changing the columns of the transition matrix. Then, pinning nodes can be chosen, and pinning control design algorithms are proposed. Finally, an example is employed to show the proposed control design procedure.
This brief investigates a pinning control design for the synchronization of two Boolean networks (BNs) coupled in the drive-response configuration. A complete synchronization for BNs can be achieved ...by changing the columns of the transition matrix of the response BN. Then, pinning nodes can be chosen, and a pinning control design algorithm is proposed. Finally, examples are given to show the effectiveness of the design procedure.
This brief studies robust stabilization for a logical system under arbitrary disturbance inputs. Feedback control and pinning control design algorithms, which relying on the disturbance inputs, are ...developed to stabilize the logical system. In order to design feedback controller, necessary and sufficient conditions for the existence of a state feedback controller are derived. Then, constructive procedures for feedback control are provided. For the purpose of designing pinning control, an algorithm to select the pinning nodes is provided. Besides, a pinning control design algorithm is given. Finally, illustrative examples are given to show the proposed results.
This paper studies the set stabilization of switched Boolean control networks, in which a feedback control design algorithm is presented by a constructive method. Necessary and sufficient conditions ...of the set stabilization of switched Boolean control networks under arbitrary switching signals are presented for the cases of the control input relying on switching signals or not, respectively. Furthermore, the corresponding switching-signal-independent and switching-signal-dependent controllers are provided for these two cases, respectively. It is shown that the condition of the switching-signal-dependent controller is less conservative than the one of the switching-signal-independent controller. Finally, examples are given to illustrate the effectiveness of the proposed results.
This paper investigates pinning control for stabilizing Boolean networks with time delays. The purpose of this paper is to design a control algorithm to select a fraction of key nodes for a Boolean ...network with time delays such that the considered Boolean network can achieve stability. First, by changing the columns of the transition matrix of a Boolean network, the stabilization of a Boolean network is investigated. By doing this, we can obtain a new transition matrix for which we can select the key nodes. Furthermore, an algorithm is then proposed to design a pinning controller. Finally, an example of pinning control of coupled oscillators in the cell cycle is presented to show the effectiveness of the proposed results.
Probabilistic Boolean network (PBN) is a kind of stochastic logical system in which update functions are randomly selected from a set of candidate Boolean functions according to a prescribed ...probability distribution at each time step. In this brief, a pinning controller design algorithm is proposed to set stabilize any PBN with probability one. First, an algorithm is given to change the columns of its transition matrix. Then, according to the newly obtained transition matrix, a fraction of nodes can be selected as pinning nodes to inject control inputs to achieve set stabilization. The problem is challenging since the Boolean functions in a PBN are not deterministic but are randomly chosen among several Boolean functions. Furthermore, the structure matrices of the pinning controllers are given by solving some logical matrices equations based on which a pinning controller design algorithm is provided to set stabilize the PBN with probability one. Finally, the theoretical results are validated using several examples.
Based on the background of education informatics, this paper uses natural language processing technology to analyze the teaching effect in the Chinese language and literature. By analyzing the basic ...methods of processing natural language, the CBOW model is constructed using text vectorization. Combined with the LDA model for Chinese language literature text, a keyword is automatically extracted. GRU is chosen as the master control unit of the information feature loop. The CBOW model is optimized using the gradient descent optimization algorithm, which improves the analysis efficiency of education and teaching. Relevant strategies for improving humanistic quality are proposed by analyzing the humanistic quality of Chinese language and literature majors in colleges and universities using natural language processing technology. The results show that the CBOW model performs better in analyzing the textual features of Chinese language and literature, and its MR value is 0.8007±0.0028 compared with the traditional neural network models such as RNN, CNN, etc. Among the strategies for improving humanistic qualities under the education of Chinese language and literature, the effect of strengthening the dissemination of cultural knowledge is 0.8. This study promotes the education of Chinese language and literature in colleges and universities to a certain degree, which is It is conducive to improving students’ humanistic literacy.
This paper investigates the controllability of Boolean networks with time-invariant delays in states. After a brief introduction on converting the logic dynamics to discrete time delay systems, the ...controllability via two kinds of controls is studied. One kind of control is generated by Boolean control networks, another kind of control is free Boolean sequences. In both cases, necessary and sufficient conditions of the controllability of Boolean control networks are proved. Finally, examples are given to illustrate the efficiency of the obtained results.
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have abilities to bind to specific target molecules that rival those of monoclonal antibodies. They are attracting ...great attention in diverse clinical translations on account of their various advantages, including prolonged storage life, little batch-to-batch differences, very low immunogenicity, and feasibility of chemical modifications for enhancing stability, prolonging the half-life in serum, and targeted delivery. In this Review, we demonstrate the emerging aptamer discovery technologies in developing advanced techniques for producing aptamers with high performance consistently and efficiently as well as requiring less cost and resources but offering a great chance of success. Further, the diverse modifications of aptamers for therapeutic applications including therapeutic agents, aptamer–drug conjugates, and targeted delivery materials are comprehensively summarized.
The effects of thawing methods (refrigeration thawing (RT, 4 °C), water immersion thawing (WT, 18 °C), vacuum thawing (VT, 25 °C), ultrasonic thawing (UT, 20 °C) and microwave thawing (MT)) on the ...conformation and gel qualities of myofibrillar protein (MP) obtained from porcine longissimus muscle were investigated. The results showed that MP conformation and gel qualities of porcine longissimus muscles by VT and UT were insignificantly changed compared to fresh meat (FM). A significant decrease in free amino groups of MP from MT illustrated that MT induced protein aggregation and oxidation (P < 0.05). The results of circular dichroism (CD) spectra analysis and fluorescence spectroscopy indirectly proved that thawing can cause protein cross-linking and degradation, secondary structure destruction, non-hydrophilic domain exposed and conformational change of samples. The largest changes in solubility, surface hydrophobicity and particle size were obtained with MT. The effects on the conformation and gel quality of MP were verified during thawing process.
•The effect of five thawing methods on gel quality of protein was compared.•Gel forming ability of protein has no obvious changes during novel thawing process.•The change of gel quality is induced by protein structural modification.
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