A cyber-physical system (CPS) is an integration of computation with physical processes whose behavior is defined by both computational and physical parts of the system. In this paper, we present a ...view of the challenges and opportunities for design automation of CPS. We identify a combination of characteristics that define the challenges unique to the design automation of CPS. We then present selected promising advances in depth, focusing on four foundational directions: combining model-based and data-driven design methods; design for human-in-the-loop systems; component-based design with contracts, and design for security and privacy. These directions are illustrated with examples from two application domains: smart energy systems and next-generation automotive systems.
Cambrian sedimentary rocks in the southern part of the South China Craton were derived from a source that lay to the south or southeast, beyond the current limits of the craton and which is no longer ...preserved nearby. U‐Pb ages and Hf isotope data on detrital zircons from the Cambrian sequence define two distinctive age peaks at 1120 Ma and 960 Ma, with εHf(t) values for each group identical to the coeval detrital zircons from Western Australia and the Tethyan Himalaya zone, respectively. The circa 1120 Ma detrital zircons were most likely derived from the Wilkes‐Albany‐Fraser belt between southwest Australia and Antarctica, whereas the circa 960 Ma detrital zircons could have been sourced from the Rayner‐Eastern Ghats belt between India and Antarctica. Derivation of detritus from these sources suggests that south China was located at the nexus between India, Antarctica, and Australia, along the northern margin of East Gondwana during the Cambrian.
Key Points
Cambrian sandstones in south China were derived from an exotic source
Source is the Wilkes‐Albany‐Fraser and Rayner‐E Ghats belts in East Gondwana
South China was located at the nexus between India, Antarctica, and Australia
High-resolution scanning radar mapping of the surface is an effective tool for addressing concerns in local environmental and social investigation fields. Regrettably, the azimuth resolution of a ...scanning radar is constrained by the antenna beamwidth. Multiple super-resolution approaches have been applied to the scanning radar to enhance the azimuth resolution, but they suffer from limited resolution improvement. In this paper, a methodology to derive surface estimates from the scanning radar at an improved azimuth resolution is proposed. We first consider the truncated spectrum by discarding the unreliable frequencies to suppress the noise amplification. Then, based on the iterative adaptive approach (IAA), a novel inverse filtering method is formulated to obtain lower sidelobes and a higher resolution. Finally, by taking advantage of the Fourier property of the steering matrix and the Toeplitz structure of the covariance matrix, we exploit the Gohberg-Semencul representation and the data-dependent trigonometric polynomials to derive a fast IAA (FIAA)-based inverse filtering to mitigate the computational burden. Simulation results and real data processing demonstrate that the proposed FIAA-based inverse filtering outperforms the existing super-resolution approaches in resolution improvement and results in a higher computational efficiency.
The ductile fracture characteristics of Chinese Q460 high strength structural steel under quasi-static condition were studied by using mechanical tests of four types of notched specimens. The ...influence of stress state on fracture mechanism of the material was investigated by observing the fracture surfaces of all test specimens using the Scanning Electron Microscope. Meanwhile, corresponding numerical simulations were conducted to collect the critical stress and strain at notch for all test specimens. The effects of stress triaxiality and Lode angle parameter, which were found to be the key parameters governing the ductile fracture of metallic material in many studies, on fracture strain of the Q460 structural steel were investigated. The analysis results show that different fracture mechanisms were observed in different stress triaxiality regions. At high stress triaxialities, Q460 steel exhibits a typical mechanism of “void nucleation, growth and coalescence”. When stress triaxiality equals to zero, a shear fracture mechanism was observed. At low stress triaxiality values, fracture develops as a combination of shear and void growth modes. In addition, the ductility of Q460 structural steel under pure shear or plane strain is lower than that under axisymmetric tension, especially at low stress triaxiality.
•The notch has an “embrittling and strengthening” effect on Q460 structural steel.•The stress triaxiality controls the ductility and fracture mechanism of the steel.•The ductility of Q460 steel is different under different Lode angle parameter.•The results can be used to calibrate micromechanical fracture models for Q460 steel.
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•The ultrastable 1T-MoS2 was successfully achieved via a gentle two-stage solvothermal strategy.•The formation of sulfur vacancies is critical to promote the transformation of 2H to ...1T phase.•Nearly 100 % 1T-MoS2 was obtained, and it remained highly stable in air even for 360 days.•The 1T-MoS2 showed superior sorption capacity, stability and recyclability for removal of Cr(VI).
Metallic 1T phase of MoS2 (1T-MoS2) has aroused great concern for decontamination of heavy metal ions from water. Herein, ultrastable 1T-MoS2 was successfully achieved via a gentle two-stage solvothermal strategy utilizing water and ethanol as solvent for efficient removal of Cr(VI). Notably, nearly 100 % 1T-MoS2 was obtained, and it remained highly stable in air even for 360 days. Electron paramagnetic resonance analysis showed that sulfur vacancies were in situ formed on the 1T/2H mixed phase MoS2 (M-MoS2) under the induction of ethanol, which is critical to promote the transformation of 2H to 1T phase. Molecular dynamic simulation revealed that there was strong interaction between ethanol and MoS2 surface, which could decrease the total energy of MoS2 for strengthening stability of 1T phase. Moreover, 1T-MoS2 shows superior sorption capacity (200.3 mg·g−1) for removal of Cr(VI), twice more than that of M-MoS2 and 2H phase MoS2 under the same condition. Significantly, the stable phase structure of 1T-MoS2 and chromium adsorption capacity still remained even after five cycles of chromium adsorption. The study of Cr(VI) adsorption mechanism revealed that the chromium adsorption was attributed to the undercoordinated Mo(IV) as active site and coupled with redox reaction during removal process.
Background: Causal evidence of circulating lipids especially the remnant cholesterol with cardiovascular and cerebrovascular disease (CVD) is lacking. This research aimed to explore the causal roles ...of extensive lipid traits especially the remnant lipids in CVD.Methods: Two-sample Mendelian randomization (TSMR) analysis was performed based on large-scale meta-analysis datasets in European ancestry. The causal effect of 15 circulating lipid profiles including 6 conventional lipids and 9 remnant lipids on coronary heart disease (CHD) and ischemic stroke (IS), as well as the subtypes, was assessed.Results: Apolipoprotein B (Apo B), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) were still important risk factors for CHD and myocardial infarction (MI) but not for IS. Apo B is the strongest which increased the CHD and MI risk by 44% and 41%, respectively. The odds ratios (ORs) of total TG on CHD and MI were 1.25 (95% confidence interval CI, 1.13–1.38) and 1.24 (95% CI, 1.11–1.38), respectively. A one standard deviation difference increased TG in medium very-low-density lipoproteins (M.VLDL.TG), TG in small VLDL (S.VLDL.TG), TG in very small VLDL (XS.VLDL.TG), TG in intermediate-density lipoproteins (IDL.TG), TG in very large HDL (XL.HDL.TG), and TG in small HDL (S.HDL.TG) particles also robustly increased the risk of CHD and MI by 9–28% and 9–27%, respectively. TG in very/extremely large VLDL (XXL.VLDL.TG and XL.VLDL.TG) were insignificant or even negatively associated with CHD (in multivariable TSMR), and negatively associated with IS as well.Conclusion: The remnant lipids presented heterogeneity and two-sided effects for the risk of CHD and IS that may partially rely on the particle size. The findings suggested that the remnant lipids were required to be intervened according to specific components. This research confirms the importance of remnant lipids and provides causal evidence for potential targets for intervention.
Inertial attitude estimation is a crucial component of many modern systems and applications. Attitude estimation from commercial-grade inertial sensors has been the subject of an abundance of ...research in recent years due to the proliferation of Inertial Measurement Units (IMUs) in mobile devices, such as the smartphone. Traditional methodologies involve probabilistic, iterative-state estimation; however, these approaches do not generalise well over changing motion dynamics and environmental conditions, as they require context-specific parameter tuning. In this work, we explore novel methods for attitude estimation from low-cost inertial sensors using a self-attention-based neural network, the Attformer. This paper proposes to part ways from the traditional cycle of continuous integration algorithms, and formulate it as an optimisation problem. This approach separates itself by leveraging attention operations to learn the complex patterns and dynamics associated with inertial data, allowing for the linear complexity in the dimension of the feature vector to account for these patterns. Additionally, we look at combining traditional state-of-the-art approaches with our self-attention method. These models were evaluated on entirely unseen sequences, over a range of different activities, users and devices, and compared with a recent alternate deep learning approach, the unscented Kalman filter and the iOS CoreMotion API. The inbuilt iOS had a mean angular distance from the true attitude of 117.31∘, the GRU 21.90∘, the UKF 16.38∘, the Attformer 16.28∘ and, finally, the UKF-Attformer had mean angular distance of 10.86∘. We show that this plug-and-play solution outperforms previous approaches and generalises well across different users, devices and activities.
In sepsis, brain dysfunction is known as Sepsis-associated encephalopathy (SAE), which often results in severe cognitive and neurological sequelae and increases the risk of death. Our systematic ...review and meta-analysis aimed to explore the diagnostic and prognostic value of serum S100 calcium-binding protein B (S100B) in SAE patients.
We conducted a systematic search of the databases PubMed, Web of Science, Embase, Cochrane databases, CNKI, VIP, and WFSD from their inception dates until August 20, 2022. A Meta-analysis of the included studies was also performed using Review Manager version 5.4 and Stata16.0.
This meta-analysis included 28 studies with 1401 serum samples from SAE patients and 1591 serum samples from no-encephalopathy septic (NE) patients. The Meta-Analysis showed that individuals with SAE had higher serum S100B level than NE controls (MD, 0.49 95% CI (0.37)-(0.60), Z =8.29,
< 0.00001), and the baseline level of serum S100B in septic patients with burn was significantly higher than average (1.96 95% CI (0.92)-(2.99), Z =3.71, P < 0.0002) In addition, septic patients with favorable outcomes had lower serum S100B levels than those with unfavorable outcomes (MD, -0.35 95% CI (-0.50)-(-0.20), Z =4.60,
< 0.00001).
Our Meta-Analysis indicates that higher serum S100B level in septic patients are moderately associated with SAE and unfavorable outcomes (The outcomes here mainly refer to the mortality). The serum S100B level may be a useful diagnostic and prognostic biomarker of SAE.
The logistics industry is a derivative industry of manufacturing services extraposition. A variety of strategies to develop the manufacturing industry are important programs of action for China's ...manufacturing strategic power, and it is of great significance to promote the high-quality development of the logistics industry. This paper takes strong manufacturing provinces with the development of the logistics industry as the research object and applies network DEA measuring the production efficiency and service efficiency of the logistics industry from 2004 to 2017. This paper adopts the "Made in China 2025" strategy as a natural experiment and uses double difference to study the impact of manufacturing policies on the high-quality development of the logistics industry. The empirical results show that compared with the Reference group, the impact of the "Made in China 2025" strategy led to a significant increase in the production efficiency and service efficiency of the experimental group. The group-based test based on innovation type shows that independent innovation has a significant positive effect on the high-quality development of the logistics industry, which shows that from the perspective of technological innovation, independent innovation is the main path of the "Made in China 2025" strategy to promote the high-quality development of the logistics industry. This paper not only identifies the causal relationship between the "Made in China 2025" strategy and the high-quality development of the logistics industry but also helps clarify the mechanism of how manufacturing policies improve the high-quality development of the logistics industry, which has important implications for further promoting the combined development between manufacturing and logistics.
Earlier reports of fabricating 3D porous PCL scaffolds for tissue engineering applications were overshadowed by several limitations such as additional molds cost, relatively low efficiency, and ...lacking process control. In present study, combined extrusion-based cryogenic 3D printing (ECP) (−20 °C) and subsequent freeze-drying approaches were employed to facilely fabricate polycaprolactone (PCL) scaffolds, with high porosity and fidelity. Freeze-drying caused shrinkage of the scaffolds along X, Y, and Z-axes to some extent. The porosities of CP600, CP800, and CP1000 were found to be 64.0 ± 1.2%, 70.1 ± 1.3%, and 74.3 ± 0.6%, respectively. The fabricated scaffolds were characterized for various structural features and compared with the ones fabricated through traditional extrusion-based melt 3D printing (EMP). The crystallinity of PCL in ECP scaffolds was lower (57.1 ± 2.2%) than EMP scaffolds (69.8 ± 1.3%). The ECP scaffolds showed high alkaline degradation, but low compression properties. The ECP scaffolds promoted the adhesion and proliferation of MCT3T-E1 cells with well-spread morphology on the porous filaments. Together, these features justify the suitability of printed PCL scaffolds for potential TE applications.
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•Facile fabrication of porous PCL 3D scaffolds via extrusion-based cryogenic 3D printing and freeze-drying.•Obtained highly porous and amorphous crystalline scaffolds.•The scaffolds possess improved degradation behavior and desired compression property for tissue engineering applications.•Highly biocompatible scaffolds in terms of improved cell adhesion, proliferation, and spreading.
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