This study aimed to analysis outcome and prognosis of interstitial 125I seed implantation in patients with cervical lymph node recurrence after multimodal treatment of thoracic esophageal squamous ...cell carcinoma (ESCC). We conducted a retrospective review of 19 patients with 32 cervical lymph nodes recurrences after multimodal treatment (lymphadenectomy, radiotherapy, chemotherapy, and various combinations of these treatments) of thoracic ESCC, who underwent 125I seed implantation in our department from 2003 to 2011. All the patients were followed up until expiration and the median duration of follow up was 7 months (range, 3-44 months). Syndromes significantly improved after implantation. The local control rates after 3, 6, 12, and 24 months were 84.2%, 63.2%, 32.0%, and 26.0%, respectively, with a median of 10 months. The median overall survival time was 7 months (95% CI, 5.6-8.4), and 1- and 2-year survival rates were 31.6% and 10.5%, respectively. Among these patients, there were 11 died of progression of disease (PD) 3-44 months after implantation. One patient presented grade IV skin toxic effect and repaired by free flap transplantation. No fatal complications such as massive bleeding happened. In univariate analysis, N stage, number of recurrent nodes, recurrence interval time, and D90 were prognostic factors of the tumor local control and survival (p = 0.131 vs. 0.029, 0.129 vs. 0.071, 0.042 vs. 0.042, and 0.056 vs. 0.065, respectively). Multivariate analysis demonstrated that N stage, number of recurrent nodes, and recurrence interval time were independent prognostic factors of the tumor local control (p = 0.022, 0.019, and <0.001, respectively), and recurrence interval time was prognostic factor of the survival (p < 0.001). Interstitial 125I seed implantation is a safe and effective salvage treatment for cervical lymph node recurrence after multimodal treatment. The N stage, number of recurrent nodes and recurrence interval time are factors influencing tumor local control, and the recurrence interval time is independent factor influencing survival after percutaneous 125I seed implantation in ESCC with cervical lymph node recurrence.
This study aimed to analysis outcome and prognosis of interstitial 125I seed implantation in patients with cervical lymph node recurrence after multimodal treatment of thoracic esophageal squamous ...cell carcinoma (ESCC). We conducted a retrospective review of 19 patients with 32 cervical lymph nodes recurrences after multimodal treatment (lymphadenectomy, radiotherapy, chemotherapy, and various combinations of these treatments) of thoracic ESCC, who underwent
125
I seed implantation in our department from 2003 to 2011. All the patients were followed up until expiration and the median duration of follow up was 7 months (range, 3-44 months). Syndromes significantly improved after implantation. The local control rates after 3, 6, 12, and 24 months were 84.2%, 63.2%, 32.0%, and 26.0%, respectively, with a median of 10 months. The median overall survival time was 7 months (95% CI, 5.6-8.4), and 1- and 2-year survival rates were 31.6% and 10.5%, respectively. Among these patients, there were 11 died of progression of disease (PD) 3-44 months after implantation. One patient presented grade IV skin toxic effect and repaired by free flap transplantation. No fatal complications such as massive bleeding happened. In univariate analysis, N stage, number of recurrent nodes, recurrence interval time, and D90 were prognostic factors of the tumor local control and survival ( p = 0.131 vs. 0.029, 0.129 vs. 0.071, 0.042 vs. 0.042, and 0.056 vs. 0.065, respectively). Multivariate analysis demonstrated that N stage, number of recurrent nodes, and recurrence interval time were independent prognostic factors of the tumor local control ( p = 0.022, 0.019, and <0.001, respectively), and recurrence interval time was prognostic factor of the survival ( p < 0.001). Interstitial
125
I seed implantation is a safe and effective salvage treatment for cervical lymph node recurrence after multimodal treatment. The N stage, number of recurrent nodes and recurrence interval time are factors influencing tumor local control, and the recurrence interval time is independent factor influencing survival after percutaneous
125
I seed implantation in ESCC with cervical lymph node recurrence.
To avoid the energy‐consuming step of direct N≡N bond cleavage, photocatalytic N2 fixation undergoing the associative pathways has been developed for mild‐condition operation. However, it is a ...fundamental yet challenging task to gain comprehensive understanding on how the associative pathways (i.e., alternating vs. distal) are influenced and altered by the fine structure of catalysts, which eventually holds the key to significantly promote the practical implementation. Herein, we introduce Fe dopants into TiO2 nanofibers to stabilize oxygen vacancies and simultaneously tune their local electronic structure. The combination of in situ characterizations with first‐principles simulations reveals that the modulation of local electronic structure by Fe dopants turns the hydrogenation of N2 from associative alternating pathway to associative distal pathway. This work provides fresh hints for rationally controlling the reaction pathways toward efficient photocatalytic nitrogen fixation.
Modulating the local electronic structure of nearby oxygen vacancy by doping enables the control of N2 hydrogenation from the associative alternating pathway to a more favorable associative distal pathway, thus contributing to improved performance for NH3 evolution in photocatalytic nitrogen fixation.
Using electroencephalography (EEG) for diagnosing subsequent epilepsy in children after febrile seizure (FS) is not common. The present study investigates the relationship between epileptiform ...discharges and subsequent epilepsy, and looks for the predictive marker for this disorder. A total of 378 children with complex FS and whose EEG showed epileptiform discharges or normal EEG were included. Development of FS was compared between those with epileptiform discharges and those with normal EEG. Risk factors were analyzed using multivariate logistic regression to clarify their effects on subsequent epilepsy. The association between generalized or focal EEG localization, and between frontal epileptiform discharges and subsequent epilepsy, were analyzed. Among 378 patients with complex FS, 51 showed epileptiform discharges. History of epilepsy, frontal seizure, number of FS, and prolonged seizure were the risk factors for epileptiform discharge. Subsequent epilepsy was significantly frequent in patients with more than 2 risk factors (odds ratio OR = 17; 95% confidence interval CI = 4.1-29.6). Prolonged seizure (OR = 4.98; 95% CI = 1.63-13.29), FS number (OR = 2.96; 95% CI = 1.23-10.51), and family history of epilepsy (OR = 2.67; 95% CI = 1.05-7.63) were significantly correlated with subsequent epilepsy. Of 9 patients with paroxysms in the frontal region, 8 (88.9%) developed epilepsy. There was concordance between frontal epileptiform discharges and subsequent epilepsy (κ = .901). In conclusion, epileptiform discharges are risk factors for subsequent epilepsy. Frontal paroxysmal EEG is a marker for subsequent epilepsy.
Abstract
Recently, organic–inorganic lead iodide perovskite has become one of the most promising emergent materials, which exhibits great potential in photovoltaics, lasing, laser cooling, etc. The ...building block of such great material is PbI
2
, a van der Waals (vdW) layered semiconductor material, which arouses increased interest also owing to its potential applications for X‐ray and γ‐ray detection, lasing, etc. Similar and even superior to some vdW layered materials such as thin layers of transition metal dichalcogenides like MoS
2
, WS
2
, MoSe
2
, or WSe
2
, PbI
2
layers possess a direct bandgap of visible frequency with a wide range of thicknesses (>3 layers). This study reports the anti‐Stokes photoluminescence (ASPL) of PbI
2
layers, which is very rarely investigated at present. Universe and robust ASPL in both 4H‐ and 2H‐PbI
2
layers are observed and a phonon‐assisted and multiphoton absorption up‐conversion mechanisms are proposed through in situ temperature‐dependent, incident laser‐power‐dependent measurements of both Stokes photoluminescence and ASPL. The successful observation and explanation of the universal anti‐Stokes emission of PbI
2
layers, will certainly enrich fundamental understandings of vdW layered semiconductors and perovskite, then further benefit to developing applications based on such emerging materials.
Nor did it replicate in a GWAS from a similar high-risk population (National Cancer Institute) or in a GWAS from a low-risk population (Beijing). ...the original finding was likely the result of ...inadequate control for population stratification using the genetically unmatched subjects or, less likely, could have been due to chance alone.
The research of anti-hepatocellular carcinoma(HCC) drug has attracted more and more attention. Natural products are the important source of active compounds for cancer treatment. A biflavonoid HIS-4 ...was isolated from Resina draconis in our previous study. MTT assay, hoechst staining, and flow cytometry analysis were used to investigate the effects of HIS-4 on the proliferation and apoptosis of human hepatoma HepG2 and SK-HEP-1 cells. Moreover, the effects of HIS-4 on the migration and invasion ability of HepG2 and SK-HEP-1 cells were evaluated by wound healing assay and Transwell assay. In addition, MTT assay, flow cytometry analyses, Hoechst staining, wound healing assay, Transwell assay, and tube formation assay were used to explore the anti-angiogenic activity of HIS-4 in human umbilical vein endothelial cells(HUVECs). Mechanistically, the HIS-4 regulatory of signal pathways in H9 epG2 and SK-HEP-1 cells were analyzed by Western blot. This results showed that HIS-4 suppressed the proliferation of human hep
Dendritic cells (DCs) must integrate a broad array of environmental cues to exact control over downstream immune responses including T
polarization. The multienzyme aminoacyl-tRNA synthetase complex ...component AIMp1/p43 responds to cellular stress and exerts pro-inflammatory functions; however, a role for DC-expressed AIMp1 in T
polarization has not previously been shown. Here, we demonstrate that the absence of AIMp1 in bone marrow-derived DC (BMDC) significantly impairs cytokine and costimulatory molecule expression, p38 MAPK signaling, and T
1 polarization of cocultured T-cells while significantly dysregulating immune-related gene expression. These deficits resulted in significantly compromised BMDC vaccine-mediated protection against melanoma. AIMp1 within the host was also critical for innate and adaptive antiviral immunity against influenza virus infection
. Cancer patients with AIMp1 expression levels in the highest tertiles exhibited a 70% survival advantage at 15-year postdiagnosis as determined by bioinformatics analysis of nearly 9,000 primary human tumor samples in The Cancer Genome Atlas database. These data establish the importance of AIMp1 for the effective governance of antitumor and antiviral immune responses.
Panonychus citri McGregor (Trombidiformes: Tetranychidae), the widely distributed citrus red mite, has developed resistance to most registered acaricides. Adaptation of arthropods to extreme ...environmental conditions has been related to increased expression of their heat shock proteins (HSPs). The objectives of this study were to explore the relationship between HSPs and resistance of Panonychus citri to the acaricide abamectin and the adaptation of Panonychus citri to high temperatures. The full-length cDNA of the HSP90 gene was cloned from an abamectin-sensitive strain of Panonychus citri. This gene consisted of 2,495 nucleotides with a complete open reading frame (ORF) of 2,169 nucleotides. This gene encoded a polypeptide of 721 amino acids with a predicted molecular weight of 83.44 kDa, a theoretical isoelectric point of 5.06, a 3′ untranslated region (UTR) of 228 bp, and a 5′ UTR of 98 bp. The results of real-time PCR analyses Indicated that the expression of the HSP90 gene in P. citri was markedly affected by the concentration of abamectin, the duration of exposure to it and the temperature, suggesting that the up-regulation of the HSP90 gene may play an important role in abamectin resistance and adaptation to high temperatures in Panonychus citri. The results of RNA interference experiments indicated that the HSP90 gene from adult female Panonychus citri was sensitive to down-regulation by double-stranded RNA (0.1–0.2 pg/µL). This study provides a molecular basis for further analysis of the relationships between the HSP90 gene and the resistance of Panonychus citri to abamectin and to high temperatures.
PDF
