The Delta variant is now replacing all other SARS-CoV-2 variants. We found a mean R0 of 5.08, which is much higher than the R0 of the ancestral strain of 2.79. Rapidly ramping up vaccine coverage ...rates while enhancing public health and social measures is now even more urgent and important.
Identification of rapid, inexpensive, and reliable prognostic factors can improve survival estimation and guide healthcare in patients with acute heart failure (AHF). In this study, we aimed to ...determine the prognostic value of the platelet-to-lymphocyte ratio (PLR) in patients with AHF. A total of 443 patients from two hospitals met the inclusion criteria from January 2010 to December 2017. Univariate and multivariate Cox analyses were performed to determine the association of PLR with survival. All-cause mortality was analysed using the Kaplan-Meier method. The 6-month survival rate for patients according to PLR quartiles (<110.63, 110.63-139.23, 139.23-177.17, and >177.17) were 90.09%, 76.79%, 50.07%, and 37.27%, respectively (p < 0.001). Univariate analysis identified high PLR (>110.63), old age (≥73 years), smoking habit, low estimated glomerular filtration rate (<57), and high platelet count (≥198 × 10
/l) as poor prognostic factors for survival. In the multivariate analysis, after adjusting for confounding factors, the third (hazard ratio HR = 3.118, 95% confidence interval CI = 1.668-5.386, p < 0.001) and fourth (HR = 2.437, 95% CI = 1.302-3.653, p < 0.001) quartiles of PLR were identified as independent prognostic factors in patients with AHF. A higher PLR was associated with poor clinical outcomes in patients with AHF and might be a novel marker in AHF management.
Our review found the effective reproduction number and basic reproduction number of the Omicron variant elicited 3.8 and 2.5 times higher transmissibility than the Delta variant, respectively. The ...Omicron variant has an average basic and effective reproduction number of 8.2 and 3.6.
In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no specific and effective drugs for treating this disease have been reported until today. ...Angiotensin-converting enzyme 2 (ACE2), a receptor of SARS-CoV-2, mediates the virus infection by binding to spike protein. Although ACE2 is expressed in the lung, kidney, and intestine, its expressing levels are rather low, especially in the lung. Considering the great infectivity of COVID-19, we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection. Here, we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein. The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody, Meplazumab, inhibits SARS-CoV-2 amplification. Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells, which can be neutralized by CD147 extracellular fragment. Viral loads are detectable in the lungs of human CD147 (hCD147) mice infected with SARS-CoV-2, but not in those of virus-infected wild type mice. Interestingly, virions are observed in lymphocytes of lung tissue from a COVID-19 patient. Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dose-dependent manner, which is specifically inhibited by Meplazumab. Furthermore, CD147 mediates virus entering host cells by endocytosis. Together, our study reveals a novel virus entry route, CD147-spike protein, which provides an important target for developing specific and effective drug against COVID-19.
lAt present, there are few investigations on students, especially primary school students. The subjects of this investigation are college students and primary school students.lSomatizatic symptoms ...were used as outcome variables, and the concern of epidemic situation was used as research factors.lUse the Somatic Self-rating Scale (SSS) suitable for Chinese native population.lDifferent stress manifestations of college students and primary school students were analyzed respectively, and relevant suggestions were provided.
The rapid, ongoing and worldwide coronavirus 2019 (COVID-19) pandemic represents a global public health emergency. Our objective was to explore the impact of the COVID-19 pandemic on somatic symptoms among Chinese college and primary school students, to provide reference data pertaining to the mental health of this population in the context of a public health emergency. In February and March 2020, we explored the somatic symptoms and concerns regarding COVID-19 of 399 college and primary school students in Sichuan Province using the Somatic Self-rating Scale (SSS) and a novel questionnaire, respectively. Logistic regression analysis and non-parametric tests were used to analyze the data. The incidence of somatic symptoms among college students was 34.85 (mild, 26.26%; moderate, 8.59%). The incidence of somatic symptoms in primary school students was 2.39% (all mild). Among the entire cohort, concern regarding COVID-19 was positively correlated with the occurrence of somatic symptoms. Somatic symptoms were more likely among college students expressing greater concern regarding the threat to life and health posed by COVID-19, and the efficacy of prevention and control measures. Among primary school students, only the concern for life and health was associated with a higher likelihood of somatic symptoms. Our data indicate that governments and other relevant agencies should implement different measures to prevent and control mental health disorders diseases in primary school and college students.
Digitalization plays an integral role in the transformation of the Omni structure. This study aims to investigate the effect of digital marketing capabilities (DMCs) and blockchain technology on ...customer-linking capabilities (CLCs), market-sensing capabilities (MSCs), consumer-brand engagement (CBE), and firm performance in China. The study was quantitative, and a simple random sampling technique was adopted for data collection. Data were collected using a structured questionnaire, 311 questionnaires were distributed, and a 5-point Likert scale was used to collect the data from the respondents who were employed in the Omni structure industries. The research hypothesis was tested using the structural equation modeling (SEM) technique. The results have identified a significant correlation and direct effect between DMCs, CLCs, MSCs, and firm performance. Remarkably, the effect of DMCs on CBE is significant. The mediating effect of MSCs and CLCs is significant between the relationship of DMCs and firm performance. The organization performance in the Omni structure depends on how well the DMCs have been employed. The DMCs influence MSCs, CLCs, and CBE. Henceforth, this study contributes by analyzing the role of DMCs in blockchain technology.
Grazing rest during the spring regreening period is the most economical and feasible measure for the ecological restoration of degraded alpine meadows and has been widely popularized and applied in ...China. The aim of the present study was to undertake a comparative analysis of the effects of grazing rest on the ecological restoration of degraded alpine meadows by plant photosynthesis and respiration. Coverage, height, ground biomass, belowground biomass of degraded alpine meadow vegetation, net photosynthetic rate, stomatal conductance, transpiration rate, intercellular CO
2
concentration, chlorophyll fluorescence parameters, relative chlorophyll content, respiration rate, metabolite content, leaf relative water content, and related mineral element content of the dominant grass
Elymus nutans
Griseb. were measured in degraded alpine grassland with different grazing rest years. The results show that grazing rest during the spring regreening period promoted the ecological restoration of degraded alpine meadows by enhancing the photosynthesis and respiration of the dominant grass
E. nutans
Griseb. Grazing rest enhanced photosynthesis in dominant grass by increasing metabolites related to the Calvin cycle, chlorophyll content, leaf relative water content, and related mineral element content. Grazing at rest enhanced the respiration of dominant grass by increasing metabolites related to the TCA cycle, leaf relative water content, and related mineral element content. This positive effect gradually became stable with increasing years of grazing rest. Our results provide a fundamental basis for the popularization and application of grazing rest during the spring regreening period on degraded Tibetan Plateau grasslands.
Covalent Organic Frameworks (COFs), an emerging class of crystalline porous materials, are proposed as a new type of support for grafting lanthanide ions (Ln3+) and employing these hybrid materials ...as ratiometric luminescent thermometers. A TpBpy‐COF—prepared from 1,3,5‐triformylphloroglucinol (Tp) and 2,2′‐bipyridine‐5,5′‐diamine (Bpy) grafted with Eu/Tb and Dy acetylacetone (acac) complexes can be successfully used as a luminescent thermometer in the 10–360 K (Eu) and 280–440 K (Tb) ranges with good sensing properties (thermal sensitivity up to 1.403 % K−1, temperature uncertainty δT<1 K above 110 K). For the Eu/Tb systems, we observe an unusual and rarely reported behavior, that is, no thermal quenching of the Tb3+ emission, a result of the absence of ion‐to‐ligand/host energy back‐transfer. The LnCOF materials proposed here could be a new class of materials employed for temperature‐sensing applications following up on the well‐known luminescent metal–organic framework thermometers.
A hot candidate: Covalent organic frameworks (COFs) are reported to be an excellent support for the grafting of lanthanide ions/complexes and allow the development of novel types of luminescent thermometers. A unique behavior, that is, no thermal quenching of the Tb3+ emission, is observed in these LnCOF materials.
Lead‐free halide perovskites have drawn wide attention as alternatives to their toxic and poorly stable lead‐based counterparts. Among them, double perovskites with Cs2AgInCl6 composition, often ...doped with various elements, have been in the spotlight owing to their intriguing optical properties, namely, self‐trapped exciton (STEs) emission and dopant‐induced photoluminescence. This interest has sparked different synthesis approaches towards both crystals and nanocrystals, and the exploration of many alloy compositions with mono‐ and trivalent cations other than Ag+ and In3+. In this Minireview we describe the recent developments on Cs2AgInCl6 bulk crystals and nanocrystals, their synthesis strategies, intrinsic optical properties, and tunable photoluminescence originating from different alloying and doping effects. We also discuss progress on computational studies aimed at understanding the thermodynamic stability, the role of defects, and the origin of photoluminescence in relation to the STEs and the direct band gap character.
Lead‐free halide perovskites such as the easily synthesized double perovskite Cs2AgInCl6 have generated great attention as promising alternatives to lead‐based counterparts. This Minireview takes a close look at Cs2AgInCl6 materials in the form of bulk crystals as well as nanocrystals in terms of doping engineering, photoluminescence modification, and fundamental theoretical understanding.
Four highly porous covalent organic frameworks (COFs) containing pyrene units were prepared and explored for photocatalytic H2O2 production. The experimental studies are complemented by density ...functional theory calculations, proving that the pyrene unit is more active for H2O2 production than the bipyridine and (diarylamino)benzene units reported previously. H2O2 decomposition experiments verified that the distribution of pyrene units over a large surface area of COFs plays an important role in catalytic performance. The Py‐Py‐COF though contains more pyrene units than other COFs which induces a high H2O2 decomposition due to a dense concentration of pyrene in close proximity over a limited surface area. Therefore, a two‐phase reaction system (water‐benzyl alcohol) was employed to inhibit H2O2 decomposition. This is the first report on applying pyrene‐based COFs in a two‐phase system for photocatalytic H2O2 generation.
Four highly porous pyrene‐based covalent organic frameworks (COFs) were prepared for photocatalytic H2O2 generation. The reported findings highlight that the presence of pyrene active sites in very close proximity leads to unwanted H2O2 decomposition. Accordingly, a biphasic system (benzyl alcohol and water) was employed to inhibit H2O2 decomposition.
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