In this paper, a novel code division multiplexing (CDM) algorithm-based reversible data hiding (RDH) scheme is presented. The covert data are denoted by different orthogonal spreading sequences and ...embedded into the cover image. The original image can be completely recovered after the data have been extracted exactly. The Walsh Hadamard matrix is employed to generate orthogonal spreading sequences, by which the data can be overlappingly embedded without interfering each other, and multilevel data embedding can be utilized to enlarge the embedding capacity. Furthermore, most elements of different spreading sequences are mutually cancelled when they are overlappingly embedded, which maintains the image in good quality even with a high embedding payload. A location-map free method is presented in this paper to save more space for data embedding, and the overflow/underflow problem is solved by shrinking the distribution of the image histogram on both the ends. This would further improve the embedding performance. Experimental results have demonstrated that the CDM-based RDH scheme can achieve the best performance at the moderate-to-high embedding capacity compared with other state-of-the-art schemes.
Solid composite electrolytes (SCEs) that combine the advantages of solid polymer electrolytes (SPEs) and inorganic ceramic electrolytes (ICEs) present acceptable ionic conductivity, high mechanical ...strength, and favorable interfacial contact with electrodes, which greatly improve the electrochemical performance of all‐solid‐state batteries compared to single SPEs and ICEs. However, there are many challenges to overcome before the practical application of SCEs, including the low ionic conductivity less than 10−3 S cm−1 at ambient temperature, poor interfacial stability, and high interfacial resistance, which greatly restrict the room temperature performance. Herein, the advances of SCEs applied in all‐solid‐state lithium batteries are presented, including the Li ion migration mechanism of SCEs, the strategies to enhance the ionic conductivity of SCEs by various morphologies of ICEs, and construction methods of the low resistance and stable interfaces of SCEs with both cathode and anode. Finally, some typical applications of SCEs in lithium batteries are summarized and future development directions are prospected. This work presents how it is quite significant to further enhance the ionic conductivity of SCEs by developing the novel SPEs with the special morphology of ICEs for advanced all‐solid‐state lithium batteries.
Herein, the advantages and ionic transport mechanisms of solid composite electrolyte (SCE) as well as the relationship between morphology of ceramic fillers and ionic conductivity of SCE are reviewed. Recent progress and strategies to settle interfacial issues for high‐performance all‐solid‐state lithium metal batteries with SCE are also concluded and future research directions of SCEs are proposed.
Besides its important role in embryonic development and homeostatic self-renewal in adult tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory functions. This is, at ...least partially, due to either repressing or enhancing the NF-κB pathway. Similarly, the NF-κB pathway either positively or negatively regulates Wnt/β-catenin signaling. Different components of the two pathways are involved in this crosstalk, forming a complex regulatory network. This review summarizes our current understanding of the molecular mechanisms underlying the cross-regulation between the two pathways and discusses their involvement in inflammation and inflammation-associated diseases such as cancer.
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•Partial-denitrification is a feasible way to supply nitrite for anammox.•Nitrite accumulation rate (NAR) increased with pH during denitrification.•The higher NAR at pH 9.0 was ...correlated with an enrichment of Thauera.•Thauera harbored more nitrate reductase than nitrite reductase.•A process for achieving partial denitrification/anammox in WWTP was proposed.
Partial-denitrification (nitrate to nitrite) can supply nitrite for anammox which can reduce organic matter consumption in wastewater treatment plants (WWTPs). In order to achieve stable partial-denitrification, the effect of pH on denitrification were investigated for 420 days in three reactors with influent pH of 5.0, 7.0 and 9.0. The results indicate that the nitrite accumulation rate (NAR) increased with pH, with average effluent NARs being 21%, 38% and 57% in the above reactors, respectively. The sludge cultivated at a high pH of 9.0 was resistant to pH shock, with a high NAR being maintained at 83% when it was exposed to a low pH of 5.0. Metagenomic analysis showed that the higher NAR at pH 9.0 was correlated with an enrichment of Thauera, which harbored more nitrate reductase (8098 hits) than nitrite reductase (2950 hits). Based on these findings, a novel process was proposed for achieving partial-denitrification/anammox in mainstream WWTPs.
Municipal solid waste incineration (MSWI) fly ash is considered as a hazardous waste that requires specific treatment before disposal. The principal treatments encompass thermal treatment, ...stabilization/solidification, and resource recovery. To maximize environmental, social, and economic benefits, the development of low-carbon and sustainable treatment technologies for MSWI fly ash has attracted extensive interests in recent years. This paper critically reviewed the state-of-the-art treatment technologies and novel resource utilization approaches for the MSWI fly ash. Innovative technologies and future perspectives of MSWI fly ash management were highlighted. Moreover, the latest understanding of immobilization mechanisms and the use of advanced characterization technologies were elaborated to foster future design of treatment technologies and the actualization of sustainable management for MSWI fly ash.
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•Review the state-of-the-art treatment technologies and recycling approaches for MSWI fly ash.•Compare the merits and demerits of various technologies for MSWI fly ash treatment.•Elaborate the latest immobilization mechanisms based on advanced characterization techniques.•Provide future perspectives for sustainable management of MSWI fly ash.
Alteration of widespread interfaces between cements and clays in geological time scales is essential to the safety assessment of radioactive waste repositories but not well understood partly due to ...the low reliability of thermodynamic data for zeolites. Here, we collected and full-scale characterized Ca-based zeolites with six types of frameworks that could possibly form in the interfaces. Besides, chemical interactions between degraded cementitious phases and rock forming minerals after equilibrating for ~6 years were investigated. By using the currently generated thermodynamic data of selected zeolites, chemical interactions in the cement/rock systems were studied, showing that no equilibrium was reached after 6 years and zeolites favored in thermodynamics, such as chabazite and gismondine rather than faujasite, can be expected to form at even longer timescale. The experimentally derived thermodynamic data was verified preliminarily by establishing consistent predominance diagrams of cement-zeolite-clay minerals, helping to predict zeolite stability domains in large timescales.
Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of different immunosuppressive molecules makes it very difficult to ...accurately predict clinical outcomes based only on a single immunosuppressive molecule. Here, we establish a comprehensive immune scoring system (ISS
) based on 6 immunosuppressive ligands (NECTIN2, CEACAM1, HMGB1, SIGLEC6, CD44, and CD155) using the LASSO method to improve prognostic accuracy and provide an additional selection strategy for adjuvant chemotherapy of gastric cancer (GC). The results show that ISS
is an independent prognostic factor and a supplement of TNM stage for GC patients, and it can improve their prognosis prediction accuracy; in addition, it can distinguish GC patients with better prognosis from those with high prognostic nutritional index score; furthermore, ISS
can also be used as a tool to select GC patients who would benefit from adjuvant chemotherapy independent of their TNM stages, MSI status and EBV status.
The blood–brain barrier (BBB) is the main bottleneck to prevent some macromolecular substance entering the cerebral circulation, resulting the failure of chemotherapy in the treatment of glioma. ...Cancer nanotechnology displays potent applications in glioma therapy owing to their penetration across BBB and accumulation into the tumor core. In this study, we have tailored the particle size of mesoporous silica nanoparticles (MSNs) through controlling the hydrolysis rate and polycondensation degree of reactants, and optimized the nanosystem that could effectively penetrate BBB and target the tumor tissue to achieve enhanced antiglioma efficacy. The nanoparticle was conjugated with cRGD peptide to enhance its cancer targeting effect, and then used to load antineoplastic doxorubicin. Therefore, the functionalized nanosystem (DOX@MSNs) selectively recognizes and binds to the U87 cells with higher expression level of ανβ3 integrin, sequentially enhancing the cellular uptake and inhibition to giloma cells, especially the particle size at 40 nm. This particle could rapidly enter cancer cells and was difficult to excrete outside the cells, thus leading to high drug accumulation. Furthermore, DOX@MSNs exhibited much higher selectivity and anticancer activity than free DOX and induced the glioma cells apoptosis through triggering ROS overproduction. Interestingly, DOX@MSNs at about 40 nm exhibited stronger permeability across the BBB, and could disrupt the VM-capability of glioma cells by regulating the expression of E-cadherin, FAK, and MMP-2, thus achieving satisfactory antiglioblastoma efficacy and avoiding the unwanted toxic side effects to normal brain tissue. Taken together, these results suggest that tailoring the particle size of MSNs nanosystem could be an effective strategy to antagonize glioblastoma and overcome BBB.
Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we showed that Gasdermin ...E (GSDME) expression level and GSDME-N domain generation determined the RTC fate response to TNFα under the condition of oxygen-glucose-serum deprivation. Deletion of Caspase-3 (Casp3) or Gsdme alleviated renal tubule damage and inflammation and finally prevented the development of hydronephrosis and kidney fibrosis after ureteral obstruction. Using bone marrow transplantation and cell type-specific Casp3 knockout mice, we demonstrated that Casp3/GSDME-mediated pyroptosis in renal parenchymal cells, but not in hematopoietic cells, played predominant roles in this process. We further showed that HMGB1 released from pyroptotic RTCs amplified inflammatory responses, which critically contributed to renal fibrogenesis. Specific deletion of Hmgb1 in RTCs alleviated caspase11 and IL-1β activation in macrophages. Collectively, our results uncovered that TNFα/Casp3/GSDME-mediated pyroptosis is responsible for the initiation of ureteral obstruction-induced renal tubule injury, which subsequentially contributes to the late-stage progression of hydronephrosis, inflammation, and fibrosis. This novel mechanism will provide valuable therapeutic insights for the treatment of obstructive nephropathy.
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