CD30 is a transmembrane glycoprotein of the tumor necrosis factor receptor superfamily included in the diagnostic algorithm of human cutaneous, anaplastic large cell and Hodgkin lymphomas and ...represents an optimal therapeutic target for CD30+ tumors. Similar diagnostic and therapeutic approaches are largely missing for feline lymphomas. Cross-reactivity of the antihuman CD30 receptor clone Ber-H2 was investigated in feline lymphomas. Comparative analysis of feline and human CD30 identified 61% identity of the amino acid sequence, with 100% identity of the main sequence of the epitope targeted by the antibody (RKQCEPDYYL). CD30 expression in normal feline tissues was restricted to rare lymphoid cells in perifollicular and interfollicular lymph node areas and in the thymic medulla. In feline lymphoma, CD30 was expressed in 4 of 33 (13%) T-cell lymphomas, 3 of 22 (14%) B-cell lymphomas, and 5 of 7 (71%) mixed-cell lymphomas, showing diffuse (1/5) or multifocal (4/5) positivity restricted to neoplastic multinucleated lymphoid cells and binucleated cells consistent with Reed-Sternberg-like cells. Based on the human classification system, cell morphology, expression of multiple markers (mixed cell components), and CD30 positivity, these cases were considered most consistent with classical Hodgkin-like lymphoma (HLL). The other 2 mixed-cell lymphomas were CD30 negative and thus most consistent with either T-cell-rich large B-cell lymphoma (TCRLBCL) or nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). These findings provide multiple data supporting the cross-reactivity of the Ber-H2 anti-CD30 clone in feline tissues and give evidence of the usefulness of CD30 in the diagnostic evaluation of feline lymphoma.
CONSIDERATIONVM AD THEOLOGOS VENETOS LIBRI TRES, DE JMMVNITATE ET LIBERTATE ECCLESIASTICA. IN QVIBVS PROPE AD VERBVM REFELLITVR LIBER DE HOC IPSO ARGVMENTO SCRIPTVS /
Considerationum ad theologos ...venetos libri tres
ARNALDI BRIXIENSIS IN MELCHIORE GOLDASTO CALVINISTA REDIVIVI VERA DESCRIPTIO ET IMAGO /
JACOBI GRETSERI SOCIETATIS IESV THEOLOGI, ATHLETICAE SPIRITVALIS GEMINAE, LEGITIMAE ET ILLEGITIMAE, LIBRI DVO, POSTREMAE MORIAE ET MANIAE PRAEDICANTICO ZEaemannicae oppositi /
Athleticae Spiritvalis Geminae, Legitimae Et Illegitimae ...
Jacobi Gretseri Societatis Jesu Theologi, Athleticae Spiritualis Geminae, Legitimae Et Illegitimae, Libri Duo ...
RESPONSVM IACOBI GRETSERI SOCIETATIS IESV THEOLOGI AD THESES AEGIDII HVNNII PRAEDICANTIS VVITEBERGENSIS, DE COLLOQVIO CVM PONTIFICIIS INEVNDO IN QVO NON PAVCA DE PROXIMA DISPVTATIONE RATISBONENSI, DEQVE CONtrouersiarum norma & iudice
Responsum Jacobi Gretseri Societatis Jesu Theologi
IACOBI GRETSERI SOCIETATIS IESV THEOLOGI, De FVNERE CHRISTIANO LIBRI TRES Aduersus Sectarios. AD REVERENDVM ADMODVM ET MAGNIFICVM DOMINVM, D. FRIDERICVM FORNERVM SS. Theologiae Doctorem, Vicarium Bambergensem, &c.
De Funere Christiano Libri Tres Adversus Sectarios
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