Nonmedical use of prescription drugs (NMUPD) among U.S. adolescents is a burgeoning public health problem. Previous studies have observed differences in rates of NMUPD among ethnic/racial groups. ...However, less is known on the social and cultural processes and mechanisms, which may influence adolescents’ prescription drug beliefs and practices. We conducted semi-structured interviews with 20 diverse 13- to 17-year-olds in an adolescent psychiatric inpatient unit to elicit in-depth, context-sensitive information about social factors relevant to NMUPD. Data analysis was completed using grounded theory and interpreted with a social ecological approach. Results highlighted the myriad of important contextual influences on adolescent NMUPD. Responses reflected factors within microsystem, exosystem, and macrosystem contexts as well as important intrapersonal factors. Furthermore, adolescents who identified as an ethnic minority also described cultural values (e.g., religion) and culturally based beliefs (e.g., mental health stigma), which influenced their prescription drug beliefs. Narratives revealed the interplay between intrapersonal factors and socialization agents, such as parents, peers, and the media, influencing prescription drug behavior. Our findings present ecologically framed insights as a first step in understanding this health risk behavior among U.S. adolescents. Implications as well as important next steps for future research and interdisciplinary prevention and intervention program development are discussed.
Background: Pollution may play a role in population trends of declining semen quality and regional differences in time to pregnancy (TTP) in industrialized societies. Dioxins including ...2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been suspected. In 1976, an explosion near Seveso, Italy resulted in the highest TCDD exposure known in residential populations. Twenty years later, we conducted a retrospective cohort study, the Seveso Women's Health Study. Methods: Of 981 participants, 472 women attempted pregnancy after the explosion, and 278 delivered a livebirth not associated with contraceptive failure. Individual serum TCDD levels were measured from samples collected soon after the explosion and extrapolated to the conception attempt. We examined the relation of TCDD levels to time to pregnancy (parameterized as the monthly probability of conception within the first 12 months of trying) and to infertility (defined as conception after at least 12 months of trying). We modeled fecundability with discrete-time Cox proportional hazards regression, and we modeled fertility with logistic regression. We tested the sensitivity of the conclusions to differing definitions of eligibility and outcome. Results: Median TCDD level was 50 parts per trillion, median time to pregnancy was 2 months, and 17% reported taking 12 or more months to conceive. For every 10-fold increase in serum TCDD, we observed a 25% increase in time to pregnancy (adjusted-fecundability odds ratio = 0.75 95% confidence interval (CI) = 0.60–0.95) and about a doubling in odds of infertility (adjusted odds ratio = 1.9 95% CI = 1.1–3.2). Results were similar for extrapolated TCDD and sensitivity analyses. Conclusions: We found dose-related increases in TTP and infertility associated with individual serum TCDD levels in the women from Seveso, Italy. These findings may have implications for fertility in industrialized areas.
Primary antibody deficiencies (PADs) are the most frequent primary immunodeficiencies in human subjects. The genetic causes of PADs are largely unknown. Sec61 translocon alpha 1 subunit (SEC61A1) is ...the major subunit of the Sec61 complex, which is the main polypeptide-conducting channel in the endoplasmic reticulum membrane. SEC61A1 is a target gene of spliced X-box binding protein 1 and strongly induced during plasma cell (PC) differentiation.
We identified a novel genetic defect and studied its pathologic mechanism in 11 patients from 2 unrelated families with PADs.
Whole-exome and targeted sequencing were conducted to identify novel genetic mutations. Functional studies were carried out ex vivo in primary cells of patients and in vitro in different cell lines to assess the effect of SEC61A1 mutations on B-cell differentiation and survival.
We investigated 2 families with patients with hypogammaglobulinemia, severe recurrent respiratory tract infections, and normal peripheral B- and T-cell subpopulations. On in vitro stimulation, B cells showed an intrinsic deficiency to develop into PCs. Genetic analysis and targeted sequencing identified novel heterozygous missense (c.254T>A, p.V85D) and nonsense (c.1325G>T, p.E381*) mutations in SEC61A1, segregating with the disease phenotype. SEC61A1-V85D was deficient in cotranslational protein translocation, and it disturbed the cellular calcium homeostasis in HeLa cells. Moreover, SEC61A1-V85D triggered the terminal unfolded protein response in multiple myeloma cell lines.
We describe a monogenic defect leading to a specific PC deficiency in human subjects, expanding our knowledge about the pathogenesis of antibody deficiencies.
Two critical perspectives were missing from the special issue entitled "Psychology of Terrorism": developmental and sociocultural. From a developmental point of view, the fact that most individuals ...who engage in terrorist groups or terroristic acts are young men is critically important. Perspectives from adolescent development, neuroscience, and social psychology can shed light on why this is the case. In addition, sociocultural perspectives are needed to answer important community-level questions, such as why some communities are more prone to having youth recruited for terrorism than others. From these perspectives, it is possible to see clearly how discrimination, social oppression, and victimization lead to negative developmental outcomes such as terrorist acts. Lastly, understanding individual and community level resilience against terrorism is necessary.
We investigated the relationship between prenatal exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment of Mexican farm-workers' children ...in California.
Participants from the Center for the Health Assessment of Mothers and Children of Salinas study, a birth cohort study, included 360 singletons with maternal serum measures of p,p'-DDT, o,p'-DDT, and p,p'-DDE. Psychomotor development and mental development were assessed with the Bayley Scales of Infant Development at 6, 12, and 24 months.
We found a approximately 2-point decrease in Psychomotor Developmental Index scores with each 10-fold increase in p,p'-DDT levels at 6 and 12 months (but not 24 months) and p,p'-DDE levels at 6 months only. We found no association with mental development at 6 months but a 2- to 3-point decrease in Mental Developmental Index scores for p,p'-DDT and o,p'-DDT at 12 and 24 months, corresponding to 7- to 10-point decreases across the exposure range. Even when mothers had substantial exposure, breastfeeding was usually associated positively with Bayley scale scores.
Prenatal exposure to DDT, and to a lesser extent DDE, was associated with neurodevelopmental delays during early childhood, although breastfeeding was found to be beneficial even among women with high levels of exposure. Countries considering the use of DDT should weigh its benefit in eradicating malaria against the negative associations found in this first report on DDT and human neurodevelopment.
BACKGROUND We examined pregnancy outcomes in New York City (NYC) and upstate New York after the September 11, 2001 World Trade Center disaster. METHODS Using birth certificate data for NY residents ...(n = 1660,401 births), we estimated risk of low birthweight (LBW: <2500 g) and preterm birth (<37 weeks) one week after September 11th versus three weeks before, and for 10 four-week intervals post-disaster versus these intervals in the two previous years. To corroborate regression results, we used time-series analysis. RESULTS One week after September 11th in NYC, we observed an adjusted odds of 1.44 for births <1500 g (P = 0.07) and 1.67 for births 1500–1999 g (P = 0.01), but a decreased odds of 2000–2499 g. We found no immediate change in LBW upstate or preterm in either location. In extended analyses, we found, in both locations, increased odds of <1500-g births around New Year and 33–36 weeks post-disaster and decreased odds of moderate preterm for several weeks post-disaster. Time-series analyses yielded similar findings. CONCLUSIONS The events of September 11, 2001 in NYC were associated with immediate increases in births <2000 g, slightly delayed decreased preterm delivery, and delayed increases in LBW among infants exposed periconception or in the first two trimesters. Stress may contribute to observed associations.
Adolescence is a time of increased risk for developing symptoms of anxiety and depression, especially for girls. The stress and social isolation experienced during confinement add new threats to ...already vulnerable adolescents' daily lives. This study is aimed at determining which sociodemographic characteristics (age, family composition, achievement), confinement habits (schedule, new hobby, sleep duration, cellphone and computer use, sports, schoolwork), and sources of support (parents and teachers) are associated with more or less internalized symptoms in Canadian adolescents. Differences between boys and girls are also investigated. Between April 8 and 30 (2020) and through an online survey, 895 Canadian adolescents (74% girls) aged between 12 and 17 years (
M
= 14.7) were recruited. Path analysis was performed to identify significant associations between sociodemographic characteristics, confinement habits, support variables, and internalized symptoms. Independent samples t-tests and invariance tests were conducted to compare boys and girls. Results suggest that certain confinement habits (time spent using cellphones, doing sports and schoolwork, finding a new hobby) and support variables (parents working outside the home) were significantly and negatively associated with internalized symptoms. Regarding the sex differences, girls used their cellphones more and invariance test results showed that all associations between predictors and symptoms were statistically similar for boys and girls. This study's results help understand better adolescents' experience in confinement. It sheds light on the habits likely to characterize those who are less at risk of experiencing distress, making it possible to better support adolescents during this challenging period.
Background: Polybrominated diphenyl ethers (PBDE), which are used as flame retardants, have been found to be higher in residents of California than of other parts of the United States. Objectives: We ...aimed to investigate the role of immigration to California on PBDE levels in Latino children. Methods: We compared serum PBDE concentrations in a population of first-generation Mexican-American 7-year-old children (n = 264), who were born and raised in California Center for Health Analysis of Mothers and Children of Salinas (CHAMACOS) study, with 5-year-old Mexican children (n = 283), who were raised in the states in Mexico where most CHAMACOS mothers had originated (Proyecto Mariposa). Results: On average, PBDE serum concentrations in the California Mexican-American children were three times higher than their mothers' levels during pregnancy and seven times higher than concentrations in the children living in Mexico. The PBDE serum concentrations were higher in the Mexican-American children regardless of length of time their mother had resided in California or the duration of the child's breast-feeding. These data suggest that PBDE serum concentrations in these children resulted primarily from postnatal exposure. Conclusions: Latino children living in California have much higher PBDE serum levels than their Mexican counterparts. Given the growing evidence documenting potential health effects of PBDE exposure, the levels in young children noted in this study potentially present a major public health challenge, especially in California. In addition, as PBDEs are being phased out and replaced by other flame retardants, the health consequences of these chemical replacements should be investigated and weighed against their purported fire safety benefits.
Adolescence is a critical developmental period as youth explore their body image and work to establish an identity. The stress of identity and body image development can be exacerbated by ...acculturative stress faced by immigrant adolescents. Using a person-centered analysis, we investigated immigrant adolescents’ (
n
= 57) profiles based on assimilation to the United States (US), weight, and body image dissatisfaction. Analyses included an exploratory two-step clustering technique using maximum likelihood estimation procedures to assign class membership. Follow-up analyses then examined latent class membership by adolescent age, gender, culture of origin, and immigration generation. Results indicated several meaningful latent groups of adolescents based on their BID, acculturation, and BMI. These profiles included one in which adolescents who were underweight and more assimilated to US culture also reported more satisfaction with their body image. A second profile emerged of adolescents who were normal weight or overweight and less assimilated, who also reported higher levels of body image dissatisfaction, with a desire to be thinner. The third cluster profile included adolescents who were of normal weight, but were higher on assimilation and were among the most dissatisfied with their body image. Our findings suggest that immigrant adolescents at all levels of acculturation are internalizing the thin body ideal prominent in the US, with a variety of implications for their sense of body image and BMI. Implications for mental and physical health care for immigrant adolescents are discussed.
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