Uvod: Koronavirusna bolest (COVID-19) je zarazna bolest uzrokovana virusom SARS-CoV- 2. Pandemija COVID-19 je nesumnjivo uticala na sve nacionalne zdravstvene sisteme na različitim nivoima. Svrha ...studije je bila da se proceni uloga Tocilizumaba u lečenju pacijenta obolelih zbog COVID-19 pneumonije Metodologija: Retrospektivna, jednocentrična serija slučajeva od 46 hospitalizovanih pacijenata sa potvrđenom COVID-19 pneumonijom koji su primili lek Tocilizumab. Praćeni su u periodu od novembra 2020 do januara 2021 godine u Klinici za pulmologiju Univerzitetskog Kliničkog centra Srbije. Rezultati: Prosečna starost pacijenata je bila 59+ 14.2 godina, a 36 (78,26%) su bili muškarci. Pacijenti su bili hospitalizovani na kliničkom odeljenju. Jedan ili više komorbiditeta je imalo 35 pacijenata (73,08%) i to : hipertenzija 23 (65.71 %), dijabetes 6 (17,14 %), kardiovaskularne bolesti 8 (22,85%) i astma 4 (11,42%) . Saturacija kiseonikom ispod 90% registrovano je kod 43 (91.48%) pacijenata pulsnim oksimetrom. IL-6 je bio povišen kod 44 pacijenata (95.65%). U hemostazi povišen ddimer je registrovan kod 41 (89.13%) i fibrinogen kod 38 pacijenata (82,6%). Zaključak: Statistički je značajna primena Tocilizumaba u regulisanju CRP i fibrinogena u referetnim vredostima. Primena imunomodulatorne terapije je pokazala značajnu regresiju na kontrolnim radiografiji pluća kod 39 (95.65%) pacijenata.
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Mycoplasma ovis is a hemoplasma parasite of sheep, goats, and reindeer; however, natural hemoplasma infection in white‐tailed deer has not previously been reported. Subsequent to finding many ...coccoid, bacillary, and ring‐shaped organisms, consistent with hemotropic mycoplasmas, on RBCs from a 72‐day‐old female white‐tailed fawn, we sought to (1) identify the putative hemoplasma observed in blood from the fawn, (2) evaluate others in the herd for hemoplasma infection, and (3) identify clinicopathologic characteristics of hemoplasma‐infected white‐tailed deer. EDTA‐anticoagulated whole blood was collected from the fawn and 8 apparently healthy does in the same herd. CBCs were performed on 7 nonclotted samples from the fawn and 6 does. DNA was extracted from all samples, followed by PCR amplification of bacterial (16S rDNA) and protozoal (18S rDNA) genes. The nearly complete 16S rDNA product from the fawn's sample was directly sequenced and compared with known sequences in the GenBank database. Samples from the fawn and 7 of 8 does were PCR‐positive using hemoplasma‐specific and M ovis‐specific protocols. The fawn was PCR‐negative for Anaplasma spp., Babesia spp., and Theileria spp. The 16S rDNA sequence from the fawn (GenBank accession number, FJ824847) was most closely related to M ovis (AF338268), having 98.5% sequence identity. The fawn had a mild nonregenerative anemia, a neutrophilic left‐shift with toxic change, aspiration bronchopneumonia, and gastrointestinal disease. Hematologic values, including blood film evaluation, in infected does were unremarkable. The M ovis‐like organism may have acted as either an opportunistic or primary pathogen in the fawn. The high occurrence of subclinical infections in the does suggests that white‐tailed deer may act as wildlife reservoirs for M ovis.
In this paper, we address the problem of autonomous search and vessel detection in an unknown GNSS-denied maritime environment with fixed-wing UAVs. The main challenge in such environments with ...limited localization, communication range, and the total number of UAVs and sensors is to implement an appropriate search strategy so that a target vessel can be detected as soon as possible. Thus we present informed and non-informed methods used to search the environment. The informed method relies on an obtained probabilistic map, while the non-informed method navigates the UAVs along predefined paths computed with respect to the environment. The vessel detection method is trained on synthetic data collected in the simulator with data annotation tools. Comparative experiments in simulation have shown that our combination of sensors, search methods and a vessel detection algorithm leads to a successful search for the target vessel in such challenging environments.
The development of three-dimensional (3D) and four-dimensional ultrasound (4D) has provided new opportunities to study fetal and even embryonic behavior. These techniques enable simultaneous spatial ...imaging of the entire fetus and its movements. Recently, multicenter studies of fetal brain function have been carried out, the aim of which is to establish the standards of embryonic and fetal peripheral and body movements and facial expression as additional diagnostic criteria for prenatal brain development. Additional studies have been conducted in order to provide more information on specific movement patterns and quality of movement in the high-risk fetus. The purpose of this paper is to review and analyze the published literature on the use of 3D and 4D ultrasound in the assessment of fetal behavior.
Cilj: Utvrditi ukupan broj i učestalost razdora međice III. i IV. stupnja u uporabi restriktivne epiziotomije te učestalost opstetričkih ozljeda analnog sfi nktera (OASIS) u odnosu na paritet, način ...dovršenja porođaja, trajanje porođaja, epiduralnu analgeziju, iskustvo porodničkog tima, porođajnu težinu i opseg glave novorođenčeta. Ispitanice i metode: U retrospektivno kliničko istraživanje uključena je 51 rodilja koje su rodile na Klinici za ginekologiju i porodništvo KB-a Sveti Duh u razdoblju od 1. siječnja 2010 do 31. prosinca 2014. s dijagnozom OASIS. Rezultati: Od ukupno 12858 vaginalnih porođaja, 77 % (n=9887) žena nije imalo epiziotomiju, dok je 23% (n=2971) imalo epiziotomiju. Ukupna učestalost OASIS-a u promatranom
razdoblju iznosila je 0,4%, s mediolateralnom epiziotomijom (0,7%) u odnosu na žene bez epiziotomije (0,3 %; p<0,05). Udio prvorodilja s OASIS-om statistički je bio viši (68,7 %) u odnosu na višerodilje (31,3%) te trajanja porođaja dulje od deset sati (p<0,05). Ukupno je bilo 33 % rodilja s rizičnim čimbenicima za nastanak OASIS-a (malrotacija glavice, distocija fetalnih ramena, OASIS u prethodnom porođaju). Nije nađena statistički značajna razlika u odnosu na porođajnu težinu novorođenčeta ispod 4000 g (78,4 %) i iznad 4000 g (21,6 %), majčin indeks tjelesne mase u učestalosti OASIS-a u odnosu na trajanje drugog porođajnog doba duže od jedan sat (43,6 %) i kraće od jedan sat (56,4 %) (p>0,05). Zaključak: Kao rizični čimbenici za nastanak OASIS-a pokazali su se prvorodnost, duljina trajanja porođaja više od deset sati te primjena epiziotomije. U trećini slučajeva s OASIS-om bili su prisutni ostali opstetrički rizični čimbenici za nastanak OASIS-a. Restriktivna uporaba epiziotomije i manualna perinealna protekcija smanjuju incidenciju razdora III. i IV. stupnja.
Mycoplasma ovis
is a hemoplasma parasite of sheep, goats, and reindeer; however, natural hemoplasma infection in white‐tailed deer has not previously been reported. Subsequent to finding many ...coccoid, bacillary, and ring‐shaped organisms, consistent with hemotropic mycoplasmas, on
RBC
s from a 72‐day‐old female white‐tailed fawn, we sought to (1) identify the putative hemoplasma observed in blood from the fawn, (2) evaluate others in the herd for hemoplasma infection, and (3) identify clinicopathologic characteristics of hemoplasma‐infected white‐tailed deer.
EDTA
‐anticoagulated whole blood was collected from the fawn and 8 apparently healthy does in the same herd.
CBC
s were performed on 7 nonclotted samples from the fawn and 6 does.
DNA
was extracted from all samples, followed by
PCR
amplification of bacterial (16S
rDNA
) and protozoal (18S
rDNA
) genes. The nearly complete 16S
rDNA
product from the fawn's sample was directly sequenced and compared with known sequences in the
G
en
B
ank database. Samples from the fawn and 7 of 8 does were
PCR
‐positive using hemoplasma‐specific and
M ovis
‐specific protocols. The fawn was
PCR
‐negative for
Anaplasma
spp.
,
Babesia
spp., and
Theileria
spp. The 16S
rDNA
sequence from the fawn (
G
en
B
ank accession number,
FJ824847
) was most closely related to
M ovis
(
AF338268
), having 98.5% sequence identity. The fawn had a mild nonregenerative anemia, a neutrophilic left‐shift with toxic change, aspiration bronchopneumonia, and gastrointestinal disease. Hematologic values, including blood film evaluation, in infected does were unremarkable. The
M ovis
‐like organism may have acted as either an opportunistic or primary pathogen in the fawn. The high occurrence of subclinical infections in the does suggests that white‐tailed deer may act as wildlife reservoirs for
M ovis
.
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