Measles Moss, William J
The Lancet (British edition),
12/2017, Volume:
390, Issue:
10111
Journal Article
Peer reviewed
Measles is a highly contagious disease that results from infection with measles virus and is still responsible for more than 100 000 deaths every year, down from more than 2 million deaths annually ...before the introduction and widespread use of measles vaccine. Measles virus is transmitted by the respiratory route and illness begins with fever, cough, coryza, and conjunctivitis followed by a characteristic rash. Complications of measles affect most organ systems, with pneumonia accounting for most measles-associated morbidity and mortality. The management of patients with measles includes provision of vitamin A. Measles is best prevented through vaccination, and the major reductions in measles incidence and mortality have renewed interest in regional elimination and global eradication. However, urgent efforts are needed to increase stagnating global coverage with two doses of measles vaccine through advocacy, education, and the strengthening of routine immunisation systems. Use of combined measles-rubella vaccines provides an opportunity to eliminate rubella and congenital rubella syndrome. Ongoing research efforts, including the development of point-of-care diagnostics and microneedle patches, will facilitate progress towards measles elimination and eradication.
Quantum optical microcombs Kues, Michael; Reimer, Christian; Lukens, Joseph M. ...
Nature photonics,
03/2019, Volume:
13, Issue:
3
Journal Article
Peer reviewed
Open access
A key challenge for quantum science and technology is to realize large-scale, precisely controllable, practical systems for non-classical secured communications, metrology and, ultimately, meaningful ...quantum simulation and computation. Optical frequency combs represent a powerful approach towards this goal, as they provide a very high number of temporal and frequency modes that can result in large-scale quantum systems. The generation and control of quantum optical frequency combs will enable a unique, practical and scalable framework for quantum signal and information processing. Here, we review recent progress on the realization of energy–time entangled optical frequency combs and discuss how photonic integration and the use of fibre-optic telecommunications components can enable quantum state control with new functionalities, yielding unprecedented capability.This Review describes quantum frequency combs that operate via photon entanglement, beginning with mode-locked quantum frequency combs followed by energy–time entanglement methods. The use of photonic integration and fibre-optic telecommunications components in enabling the quantum state control are also discussed.
Measles Moss, William J, Dr; Griffin, Diane E, MD
The Lancet (British edition),
01/2012, Volume:
379, Issue:
9811
Journal Article
Peer reviewed
Summary Measles is a highly contagious disease caused by measles virus and is one of the most devastating infectious diseases of man—measles was responsible for millions of deaths annually worldwide ...before the introduction of the measles vaccines. Remarkable progress in reducing the number of people dying from measles has been made through measles vaccination, with an estimated 164 000 deaths attributed to measles in 2008. This achievement attests to the enormous importance of measles vaccination to public health. However, this progress is threatened by failure to maintain high levels of measles vaccine coverage. Recent measles outbreaks in sub-Saharan Africa, Europe, and the USA show the ease with which measles virus can re-enter communities if high levels of population immunity are not sustained. The major challenges for continued measles control and eventual eradication will be logistical, financial, and the garnering of sufficient political will. These challenges need to be met to ensure that future generations of children do not die of measles.
Both groups used an adenoviral vector, and both report the vaccine achieving humoral responses to the SARS-CoV-2 spike glycoprotein receptor binding domain by day 28 as well as T-cell responses. ...Without drawing causal inference, the exploration of associations of age and sex with adverse events and immunogenicity reported by Chen and colleagues, and of longevity of response by Pollard and colleagues, are welcomed, given the differential burden of severe outcomes in older adults, and the emerging science around differential sex-specific vaccine effects.4 These COVID-19 vaccine trials are small so inferential caution is warranted, but the explorations are laudable. Hand in hand with the trajectory of vaccine study, pharmacovigilance infrastructure is urgently needed, including surveillance for asymptomatic infection among vaccinated and unvaccinated persons if both absolute and relative risk of adverse vaccine outcomes, such as enhanced disease, are to be determined.9 These should be implemented in parallel with phase 3 trials and in preparation for phase 4 roll-out.
Rubella Winter, Amy K; Moss, William J
The Lancet (British edition),
04/2022, Volume:
399, Issue:
10332
Journal Article
Peer reviewed
Rubella is an acute illness caused by rubella virus and characterised by fever and rash. Although rubella is a clinically mild illness, primary rubella virus infection in early pregnancy can result ...in congenital rubella syndrome, which has serious medical and public health consequences. WHO estimates that approximately 100 000 congenital rubella syndrome cases occur per year. Rubella virus is transmitted through respiratory droplets and direct contact. 25–50% of people infected with rubella virus are asymptomatic. Clinical disease often results in mild, self-limited illness characterised by fever, a generalised erythematous maculopapular rash, and lymphadenopathy. Complications include arthralgia, arthritis, thrombocytopenic purpura, and encephalitis. Common presenting signs and symptoms of congenital rubella syndrome include cataracts, sensorineural hearing impairment, congenital heart disease, jaundice, purpura, hepatosplenomegaly, and microcephaly. Rubella and congenital rubella syndrome can be prevented by rubella-containing vaccines, which are commonly administered in combination with measles vaccine. Although global rubella vaccine coverage reached only 70% in 2020 global rubella eradiation remains an ambitious but achievable goal.
The Ebola epidemic in West Africa has caused substantial morbidity and mortality. The outbreak has also disrupted health care services, including childhood vaccinations, creating a second public ...health crisis. We project that after 6 to 18 months of disruptions, a large connected cluster of children unvaccinated for measles will accumulate across Guinea, Liberia, and Sierra Leone. This pool of susceptibility increases the expected size of a regional measles outbreak from 127,000 to 227,000 cases after 18 months, resulting in 2000 to 16,000 additional deaths (comparable to the numbers of Ebola deaths reported thus far). There is a clear path to avoiding outbreaks of childhood vaccine-preventable diseases once the threat of Ebola begins to recede: an aggressive regional vaccination campaign aimed at age groups left unprotected because of health care disruptions.
Taking advantage of quantum mechanics for executing computational tasks faster than classical computers1 or performing measurements with precision exceeding the classical limit2,3 requires the ...generation of specific large and complex quantum states. In this context, cluster states4 are particularly interesting because they can enable the realization of universal quantum computers by means of a ‘one-way’ scheme5, where processing is performed through measurements6. The generation of cluster states based on sub-systems that have more than two dimensions, d-level cluster states, provides increased quantum resources while keeping the number of parties constant7, and also enables novel algorithms8. Here, we experimentally realize, characterize and test the noise sensitivity of three-level, four-partite cluster states formed by two photons in the time9 and frequency10 domain, confirming genuine multi-partite entanglement with higher noise robustness compared to conventional two-level cluster states6,11–13. We perform proof-of-concept high-dimensional one-way quantum operations, where the cluster states are transformed into orthogonal, maximally entangled d-level two-partite states by means of projection measurements. Our scalable approach is based on integrated photonic chips9,10 and optical fibre communication components, thus achieving new and deterministic functionalities.
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