Three principal granite provinces are defined across SE Asia, as follows. (1) The Western Thailand-Myanmar/Burma province consists of hornblende-biotite I-type granodiorite-granites and felsic ...biotite-K-feldspar (± garnet ± tourmaline) granites associated with abundant tin mineralization in greisen-type veins. New ion microprobe U-Pb dating results from Phuket Island show zircon core ages of 212 ± 2 and 214 ± 2 Ma and a thermal overprint with rims of 81.2 ± 1.2 and 85-75 Ma. (2) The North Thailand-West Malaya Main Range province has mainly S-type biotite granites and abundant tin mineralization resulting from crustal thickening following collision of the Sibumasu plate with Indochina during the Mid-Triassic. Biotite granites around Kuala Lumpur contain extremely U-rich zircons (up to 38000 ppm) that yield ages of 215 ± 7 and 210 ± 7 Ma. (3) The East Malaya province consists of dominantly Permian-Triassic I-type hornblende-biotite granites but with subordinate S-type plutons and A-type syenite-gabbros. Biotite-K-feldspar granites from Tioman Island off the east coast of Malaysia also yield a zircon age of 80 ± 1 Ma, showing Cretaceous magmatism in common with province 1. Geological and U-Pb geochronological data suggest that two east-dipping (in present-day coordinates) subduction zones are required during the Triassic, one along the Bentong-Raub Palaeo-Tethyan suture, and the other west of the Phuket-Burma province 1 belt. SUPPLEMENTARY MATERIAL: A full description of U-Pb analytical methods used and data tables are available at www.geolsoc.org.uk/SUP18523.
Abstract
Background
The ongoing pandemic is having a collateral health effect on delivery of surgical care to millions of patients. Very little is known about pandemic management and effects on other ...services, including delivery of surgery.
Methods
This was a scoping review of all available literature pertaining to COVID-19 and surgery, using electronic databases, society websites, webinars and preprint repositories.
Results
Several perioperative guidelines have been issued within a short time. Many suggestions are contradictory and based on anecdotal data at best. As regions with the highest volume of operations per capita are being hit, an unprecedented number of operations are being cancelled or deferred. No major stakeholder seems to have considered how a pandemic deprives patients with a surgical condition of resources, with patients disproportionally affected owing to the nature of treatment (use of anaesthesia, operating rooms, protective equipment, physical invasion and need for perioperative care). No recommendations exist regarding how to reopen surgical delivery. The postpandemic evaluation and future planning should involve surgical services as an essential part to maintain appropriate surgical care for the population during an outbreak. Surgical delivery, owing to its cross-cutting nature and synergistic effects on health systems at large, needs to be built into the WHO agenda for national health planning.
Conclusion
Patients are being deprived of surgical access, with uncertain loss of function and risk of adverse prognosis as a collateral effect of the pandemic. Surgical services need a contingency plan for maintaining surgical care in an ongoing or postpandemic phase.
Graphical Abstract
Surgical services are adapting to mitigate the surge in patients with COVID-19 in need of critical care support. All non-essential elective surgery has been cancelled, or is pending cancellation, in healthcare systems around the globe, impacting millions of patients. The postpandemic phase will require re-establishment of surgical services, and capacity building to restore normalcy and to appropriately reduce the backlog of cases by priority. A framework for evaluation and a plan to incorporate surgical care into the WHO strategies for national health plans and pandemic mitigation is urgently needed.
Graphical Abstract
Preparing for the next wave
Abstract
We report on the discovery of FRB 20200120E, a repeating fast radio burst (FRB) with a low dispersion measure (DM) detected by the Canadian Hydrogen Intensity Mapping Experiment FRB project. ...The source DM of 87.82 pc cm
−3
is the lowest recorded from an FRB to date, yet it is significantly higher than the maximum expected from the Milky Way interstellar medium in this direction (∼50 pc cm
−3
). We have detected three bursts and one candidate burst from the source over the period 2020 January–November. The baseband voltage data for the event on 2020 January 20 enabled a sky localization of the source to within ≃14 arcmin
2
(90% confidence). The FRB localization is close to M81, a spiral galaxy at a distance of 3.6 Mpc. The FRB appears on the outskirts of M81 (projected offset ∼20 kpc) but well inside its extended H
i
and thick disks. We empirically estimate the probability of a chance coincidence with M81 to be <10
−2
. However, we cannot reject a Milky Way halo origin for the FRB. Within the FRB localization region, we find several interesting cataloged M81 sources and a radio point source detected in the Very Large Array Sky Survey. We search for prompt X-ray counterparts in Swift Burst Alert Telescope and Fermi/GBM data, and, for two of the FRB 20200120E bursts, we rule out coincident SGR 1806−20-like X-ray bursts. Due to the proximity of FRB 20200120E, future follow-up for prompt multiwavelength counterparts and subarcsecond localization could be constraining of proposed FRB models.
Clinicians need improved tools to better identify nonacute heart failure with preserved ejection fraction (HFpEF).
The purpose of this study was to derive and validate circulating microRNA signatures ...for nonacute heart failure (HF).
Discovery and validation cohorts (N = 1,710), comprised 903 HF and 807 non-HF patients from Singapore and New Zealand (NZ). MicroRNA biomarker panel discovery in a Singapore cohort (n = 546) was independently validated in a second Singapore cohort (Validation 1; n = 448) and a NZ cohort (Validation 2; n = 716).
In discovery, an 8-microRNA panel identified HF with an area under the curve (AUC) 0.96, specificity 0.88, and accuracy 0.89. Corresponding metrics were 0.88, 0.66, and 0.77 in Validation 1, and 0.87, 0.58, and 0.74 in Validation 2. Combining microRNA panels with N-terminal pro–B-type natriuretic peptide (NT-proBNP) clearly improved specificity and accuracy from AUC 0.96, specificity 0.91, and accuracy 0.90 for NT-proBNP alone to corresponding metrics of 0.99, 0.99, and 0.93 in the discovery and 0.97, 0.96, and 0.93 in Validation 1. The 8-microRNA discovery panel distinguished HFpEF from HF with reduced ejection fraction with AUC 0.81, specificity 0.66, and accuracy 0.72. Corresponding metrics were 0.65, 0.41, and 0.56 in Validation 1 and 0.65, 0.41, and 0.62 in Validation 2. For phenotype categorization, combined markers achieved AUC 0.87, specificity 0.75, and accuracy 0.77 in the discovery with corresponding metrics of 0.74, 0.59, and 0.67 in Validation 1 and 0.72, 0.52, and 0.68 in Validation 2, as compared with NT-proBNP alone of AUC 0.71, specificity 0.46, and accuracy 0.62 in the discovery; with corresponding metrics of 0.72, 0.44, and 0.57 in Validation 1 and 0.69, 0.48, and 0.66 in Validation 2. Accordingly, false negative (FN) (81% Singapore and all NZ FN cases were HFpEF) as classified by a guideline-endorsed NT-proBNP ruleout threshold, were correctly reclassified by the 8-microRNA panel in the majority (72% and 88% of FN in Singapore and NZ, respectively) of cases.
Multi-microRNA panels in combination with NT-proBNP are highly discriminatory and improved specificity and accuracy in identifying nonacute HF. These findings suggest potential utility in the identification of nonacute HF, where clinical assessment, imaging, and NT-proBNP may not be definitive, especially in HFpEF.
Display omitted
Shearography and thermography are optical techniques, both proven to be valuable tools for material nondestructive evaluation. Papers on these topics, however, are scattered and mainly appeared in ...optical journals. For the convenience of the materials community, this paper aims to present a comprehensive review of shearography and active thermography and their applications in nondestructive evaluation of materials. Both techniques enjoy the merits of full-field, non-contact and allowing speedy detection of material defects in metal, non-metal as well as composites materials. However, they are fundamentally different in flaw detection mechanisms. Shearography measures materials’ mechanical response to stresses, whereas active thermography measures material's heat-transfer response to an instantaneous thermal excitation. A comparison of the advantages and limitations of two techniques for nondestructive evaluation will also be presented.
Previous mass screening studies have shown that IgA antibodies against Epstein–Barr Virus (EBV) can facilitate early detection of nasopharyngeal carcinoma (NPC), but the impact of EBV-antibody ...screening for NPC-specific mortality remains unknown.
A prospective, cluster randomized, controlled trial for NPC screening (PRO-NPC-001) was conducted in 3 selected towns of Zhongshan City and 13 selected towns of Sihui City in southern China beginning in 2008. Serum samples of the screening group were tested for two previously selected anti-EBV antibodies. Subjects with serological medium risk were subsequently retested annually for 3 years, and those with serological high risk were referred to otorhinolaryngologists for diagnostic check-up. An interim analysis was carried out to evaluate the primary end points of the NPC-specific mortality and the early diagnostic rate, and the secondary end point of the NPC incidence, through linkage with the database of Zhongshan City.
Among 70 296 total subjects, 29 413 screened participants (41.8% of the total subjects) in the screening group and 50 636 in the control group, 153 (43.3 per 100 000 person-year), 62 (55.3 per 100 000 person-year) and 99 (33.1 per 100 000 person-year) NPC cases were identified. The early diagnostic rates of NPC were significantly higher in the participants (79.0%, P < 0.0001) and the screening group (45.9%, P < 0.0001) compared with the control group (20.6%). Although no differences were found between NPC-specific mortality of the screening group and the control group relative risk (RR)= 0.82, 95% confidence interval (CI) 0.37–1.79, lower NPC-specific mortality was noticed among participants from the screening group versus the control group (RR = 0.22, 95% CI 0.09–0.49).
IgA antibodies against EBV can identify high-risk population and was effective in screening for early asymptomatic NPC. Although the mortality reduction was not significant in the primary end point, we noted encouraging evidence of a mortality reduction in screening participants in this interim analysis.
NCT00941538.
Although evapotranspiration-induced matric suction for single species has been widely studied, little is known about how mixed-species planting would affect plant growth and induced matric suction. ...This study aims to explore the effects of grass–tree interaction on their growth and induced matric suction during evapotranspiration (ET) and rainfalls. Field monitoring was carried out to measure matric suction responses in compacted soil that was vegetated with (i) single tree species, Schefflera heptaphylla, and (ii) mixed species of the trees and a grass species, Cynodon dactylon. In each condition, three tree spacings (120, 180, and 240 mm) were planted. When tree spacing increased from 120 to 240 mm, the peak tree root area index (RAI, for fine roots with diameter <2 mm) decreased by 16%, but the peak grass RAI increased by 29%. At mixed planting plots, the ET-induced peak matric suction for a tree spacing of 240 mm was 20% higher than that for a spacing of 180 mm because of increased contribution of grass-root water uptake as the trees were more widely spaced. Without grass, a reverse trend was observed as tree–tree interaction reduced at wide spacings. The peak ET-induced matric suction had a significant linear correlation with RAI. During rainfalls, the highest matric suction was preserved for the case of 240 mm spacing due to the greatest reduction of soil hydraulic conductivity by the presence of roots.
The discovery of a repeating fast radio burst (FRB) source
, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many ...recent discoveries and follow-ups
, suggesting that repeaters may be rare in the FRB population. Here we report the detection of six repeat bursts from FRB 180814.J0422+73, one of the 13 FRBs detected
by the Canadian Hydrogen Intensity Mapping Experiment (CHIME) FRB project
during its pre-commissioning phase in July and August 2018. These repeat bursts are consistent with originating from a single position on the sky, with the same dispersion measure, about 189 pc cm
. This traces approximately twice the expected Milky Way column density, and implies an upper limit on the source redshift of 0.1, at least a factor of about 2 closer than FRB 121102
. In some of the repeat bursts, we observe sub-pulse frequency structure, drifting, and spectral variation reminiscent of that seen in FRB 121102
, suggesting similar emission mechanisms and/or propagation effects. This second repeater, found among the first few CHIME/FRB discoveries, suggests that there exists-and that CHIME/FRB and other wide-field, sensitive radio telescopes will find-a substantial population of repeating FRBs.
Organic aerosols (OA) can be separated with factor analysis of aerosol mass spectrometer (AMS) data into hydrocarbon-like OA (HOA) and oxygenated OA (OOA). We develop a new method to parameterize H:C ...of OOA in terms of f43 (ratio of m/z 43, mostly C2H3O+, to total signal in the component mass spectrum). Such parameterization allows for the transformation of large database of ambient OOA components from the f44 (mostly CO2+, likely from acid groups) vs. f43 space ("triangle plot") (Ng et al., 2010) into the Van Krevelen diagram (H:C vs. O:C) (Van Krevelen, 1950). Heald et al. (2010) examined the evolution of total OA in the Van Krevelen diagram. In this work total OA is deconvolved into components that correspond to primary (HOA and others) and secondary (OOA) organic aerosols. By deconvolving total OA into different components, we remove physical mixing effects between secondary and primary aerosols which allows for examination of the evolution of OOA components alone in the Van Krevelen space. This provides a unique means of following ambient secondary OA evolution that is analogous to and can be compared with trends observed in chamber studies of secondary organic aerosol formation. The triangle plot in Ng et al. (2010) indicates that f44 of OOA components increases with photochemical age, suggesting the importance of acid formation in OOA evolution. Once they are transformed with the new parameterization, the triangle plot of the OOA components from all sites occupy an area in Van Krevelen space which follows a ΔH:C/ΔO:C slope of ~ −0.5. This slope suggests that ambient OOA aging results in net changes in chemical composition that are equivalent to the addition of both acid and alcohol/peroxide functional groups without fragmentation (i.e. C-C bond breakage), and/or the addition of acid groups with fragmentation. These results provide a framework for linking the bulk aerosol chemical composition evolution to molecular-level studies.
Summary Background Dengue infection is the most common mosquito-borne viral disease worldwide, but no suitable antiviral drugs are available. We tested the α-glucosidase inhibitor celgosivir as a ...treatment for acute dengue fever. Methods To establish eligibility for inclusion in a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial, individuals aged 21–65 years who had had a fever (≥38°C) for less than 48 h, met at least two criteria indicating probable dengue infection, and had a positive result on a dengue point-of-care test kit or PCR assay were referred for screening at a centre in Singapore between July 30, 2012, and March 4, 2013. Using a web-based system, we randomly assigned patients who met full inclusion criteria after screening (1:1; random permuted block length four) to celgosivir (initial 400 mg loading dose within 6 h of randomisation, followed by 200 mg every 12 h for a total of nine doses) or matched placebo. Patients and the entire study team were masked to group assignment. The primary endpoints were mean virological log reduction (VLR) from baseline for days 2, 3, and 4, and area under the fever curve (AUC) for a temperature above 37°C from 0 h to 96 h. Efficacy analyses were by intention to treat. This study is registered with ClinicalTrials.gov , number NCT01619969. Findings We screened 69 patients and randomly assigned 50 (24 to celgosivir, 26 to placebo). Mean VLR was greater in the celgosivir group (–1·86, SD 1·07) than in the placebo group (–1·64, 0·75), but the difference was non-significant (–0·22, 90% CI −0·65 to 0·22; one-sided p=0·203). The mean AUC was also higher in the celgosivir group (54·92, SD 31·04) than in the placebo group (40·72, 18·69), but again the difference was non-significant (14·20, 90% CI 2·16–26·25; one-sided p=0·973). We noted similar incidences of adverse events between groups. Interpretation Although generally safe and well tolerated, celgosivir does not seem to reduce viral load or fever burden in patients with dengue. Funding STOP Dengue Translational Clinical Research.
PDF
