This study aimed to investigate the influence of serum folate, vitamin B12 (VitB12) levels, and inflammation-based scores on the motor performance status in Parkinson's disease (PD). We ...retrospectively collected data from 148 consecutive patients with idiopathic PD first admitted to our hospital. We measured whole blood count, albumin, lactate dehydrogenase, C-reactive protein, folate, and VitB12 levels and calculated the inflammation-based scores. The following scales were applied to assess the motor performance status: activity of daily living scale (ADL, the Barthel Index), the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III), and Hoehn–Yahr (H–Y) classification. The geometric mean of folate and VitB12 levels were 11.87 (ng/ml) and 330.52 (pmol/L), respectively. Folate deficiency (serum level < 4.0 ng/ml) and VitB12 deficiency (serum level < 133 pg/ml) were present in 0.7 and 5.4% of the patients, respectively. The mean prognostic nutritional index (PNI) and systemic immune-inflammation index (SII) were 47.78 ± 4.42 and 470.81 ± 254.05, respectively. The multivariate analyses showed that serum VitB12 level (
P
= 0.002) and SII (
P
= 0.005) were significant factors for ADL score; serum folate (
P
= 0.027) and VitB12 (
P
= 0.037) levels for UPDRS-III score; and serum folate (
P
= 0.066) and VitB12 (
P
= 0.017) levels for H–Y classification. The elevated folate level did correlate with greater decline in UPDRS-III score (
P
= 0.023) and H–Y classification (
P
= 0.003), whereas there was an obvious increase in ADL score (
P
= 0.048). SII was negatively associated (
P
< 0.001) with the ADL score. The three-dimensional drawing, combined with the effect of folate and VitB12 levels, showed that the lowest level of folate was associated with the lowest ADL score and the highest UPDRS-III score and H–Y classification. This study indicates that serum folate, VitB12 levels, and SII are significant factors influencing the motor performance status in patients with PD. SII is negatively associated with ADL. Elevated serum folate level correlates with mild motor impairment in patients with PD.
Freezing of gait (FOG) is a serious complication in patients with Parkinson's disease (PD), and is more common in the late state of the disease. The high risk of falling in patients with FOG impacts ...their quality of life.
To explore altered neuroactivity related to cognitive and executive function of PD patients with FOG.
Fourteen PD patients with FOG (FOG+), 20 PD patients without FOG (FOG−), and 18 normal controls (NC) were enrolled. Functional MRI data of all PD patients were collected during OFF medication state. Data were analyzed using software of DPARSF and REST. Resting brain activity was measured by regional homogeneity (ReHo). ANOVA test was performed for ReHo among FOG, PD, and NC groups.
ReHo alterations of left supplementary motor area (SMA) (Brodmann 6), left superior frontal region (Brodmann 9), and the right putamen (Brodmann 48) were significantly different among the three groups. The ReHo values within left SMA (Brodmann 6) and left superior frontal region (Brodmann 9) were significantly decreased in FOG+ patients compared with FOG− patients.
Changes in neural hypoactivity within the frontal region and SMA appear to be associated with FOG in PD patients, which suggests that the mechanism underlying FOG may relate to disruption of execution and cognition.
•FOG is no longer considered as a pure motor phenomenon, but rather a complex interplay between motor and cognitive factors.•The changes in neural hypoactivity within the frontal region and SMA are associated with FOG in PD patients.•It might be helpful to provide a supporting theory for cognitive training therapy in PD FOG+ patients.
Parkinson’s disease (PD), a chronic neurodegenerative disease, is characterized by sensorimotor and cognitive deficits. Previous diffusion tensor imaging (DTI) studies found abnormal DTI metrics in ...white matter bundles, such as the corpus callosum, cingulate, and frontal-parietal bundles, in PD patients. These studies mainly focused on alterations in microstructural features of long-range bundles within the deep white matter (DWM) that connects pairs of distant cortical regions. However, less is known about the DTI metrics of the superficial white matter (SWM) that connects local cortical regions in PD patients. To determine whether the DTI metrics of the SWM were different between the PD patients and the healthy controls, we recruited DTI data from 34 PD patients and 29 gender- and age-matched healthy controls. Using a probabilistic tractographic approach, we first defined a population-based SWM mask across all the subjects. Using a tract-based spatial statistical (TBSS) analytic approach, we then identified the SWM bundles showing abnormal DTI metrics in the PD patients. We found that the PD patients showed significantly lower DTI metrics in the SWM bundles connecting the sensorimotor cortex, cingulate cortex, posterior parietal cortex (PPC), and parieto-occipital cortex than the healthy controls. We also found that the clinical measures in the PD patients was significantly negatively correlated with the fractional anisotropy in the SWM (
FA
SWM
) that connects core regions in the default mode network (DMN). The
FA
SWM
in the bundles that connected the PPC was significantly positively correlated with cognitive performance in the PD patients. Our findings suggest that SWM may serve as the brain structural basis underlying the sensorimotor deficits and cognitive degeneration in PD patients.
Backgrounds
Bile acid (BA) plays a crucial role in various neurodegenerative diseases, including Parkinson's disease (PD). However, no clinical evidence supports BA's potential role in patients with ...PD with mild cognitive impairment (PD-MCI).
Objectives
This study aimed at investigating the differential BA profile between patients with PD-MCI and those with normal cognitive function (PD-NC).
Methods
Ultra-high performance liquid chromatography-MS/MS was applied for BA quantitation. After between-group differences of the BA profile were addressed, orthogonal projections to latent structures—discriminant analysis (OPLS-DA) and the area under the receiver-operating-characteristic curve (AUC-ROC) were implemented for further verification.
Results
Lower levels of chenodeoxycholic acid (CDCA), cholic acid (CA), and ursodeoxycholic acid (UDCA) were significantly associated with PD-MCI (
p
< 0.01 for both; VIP ≈ 2.67, 1.66, and 1.26, respectively). AUC-ROC were 78.1, 74.2, and 74.5% for CDCA, CA, and UDCA, respectively.
Conclusion
CA, CDCA, and UDCA might be distinct BA signatures for patients with PD-MCI.
Objective
To investigate white matter microstructural alterations in Parkinson's disease (PD) patients with depression using the whole-brain diffusion tensor imaging (DTI) method and to explore the ...DTI–based machine learning model in identifying depressed PD (dPD).
Methods
The DTI data were collected from 37 patients with dPD and 35 patients with non-depressed PD (ndPD), and 25 healthy control (HC) subjects were collected as the reference. An atlas-based analysis method was used to compare fractional anisotropy (FA) and mean diffusivity (MD) among the three groups. A support vector machine (SVM) was trained to examine the probability of discriminating between dPD and ndPD.
Results
As compared with ndPD, dPD group exhibited significantly decreased FA in the bilateral corticospinal tract, right cingulum (cingulate gyrus), left cingulum hippocampus, bilateral inferior longitudinal fasciculus, and bilateral superior longitudinal fasciculus, and increased MD in the right cingulum (cingulate gyrus) and left superior longitudinal fasciculus-temporal part. For discriminating between dPD and ndPD, the SVM model with DTI features exhibited an accuracy of 0.70 in the training set area under the receiver operating characteristic curve (ROC) was 0.78 and an accuracy of 0.73 in the test set (area under the ROC was 0.71).
Conclusion
Depression in PD is associated with white matter microstructural alterations. The SVM machine learning model based on DTI parameters could be valuable for the individualized diagnosis of dPD.
Lead‐free halide perovskites possess excellent photoelectric properties, making them widely used in the photoelectric fields. Herein, lead‐free double perovskite crystals (PCs) doped with manganese ...(Cs2NaInCl6:Mn2+) are successfully prepared by the more energy‐efficient crystallization method. The crystals emit bright orange‐red light under the ultraviolet (UV) lamp, showing unique optical properties. They have the highest photoluminescence quantum yield of 42.91%. The white light‐emitting diodes (LEDs) are fabricated using these perovskite crystals, which show a color rendering index of 92 and external quantum efficiency (EQE) as high as 16.3%. Furtherly, perovskite‐modified fiber paper made of aramid chopped fibers (ACFs) and polyphenylene sulfide (PPS) exhibited fluorescent properties under different conditions. This paper combines fiber composite technology with PPS fiber filter bags, which are widely used in environmental protection, for the first time and demonstrates functional fiber filter bags with fluorescent characteristics. This filter bag provides an idea for the automatic detection of industrial filtration. Meanwhile, after being exposed to industrial waste gas for 60 h, the filter bag can maintain superior fluorescence performance. In this study, lead‐free double perovskites are synthesized using an efficient method for preparing high‐performance LEDs and high‐stability fluorescent fibers. Concurrently, the application of perovskites in environmental protection is expanded.
Manganese‐doped halide perovskites with high photoluminescent quantum yield can be used to prepare LEDs and fluorescent composite fibers with high external quantum efficiency. The fluorescent fiber filter bag is developed based on fluorescent composite fiber, which provides a new idea for detecting filter bag damage in industrial waste gas filtration systems.
G3BP RNA-binding proteins are important components of stress granules (SGs). Here, we analyze the role of the Drosophila G3BP Rasputin (RIN) in unstressed cells, where RIN is not SG associated. ...Immunoprecipitation followed by microarray analysis identifies over 550 mRNAs that copurify with RIN. The mRNAs found in SGs are long and translationally silent. In contrast, we find that RIN-bound mRNAs, which encode core components of the transcription, splicing, and translation machinery, are short, stable, and highly translated. We show that RIN is associated with polysomes and provide evidence for a direct role for RIN and its human homologs in stabilizing and upregulating the translation of their target mRNAs. We propose that when cells are stressed, the resulting incorporation of RIN/G3BPs into SGs sequesters them away from their short target mRNAs. This would downregulate the expression of these transcripts, even though they are not incorporated into stress granules.
Display omitted
•In early embryos, the Drosophila G3BP Rasputin (RIN) is polysome associated•RIN binds over 550 mRNAs, which are short, stable, and highly translated•In rin mutants, steady-state levels of its target mRNAs are reduced•Tethering RIN or human G3BPs enhances the expression of a luciferase reporter mRNA
Laver et al. show that in early embryos, Rasputin, the Drosophila G3BP ortholog, binds short mRNAs and is associated with polysomes. They provide evidence for a direct role for Rasputin and its human homologs in stabilizing and upregulating the translation of their target mRNAs.
Objective:
To study the effects of acupuncture on expression of heat shock protein (Hsp) 84 and 86, and brain ageing, in the senescence accelerated mouse prone 8 (SAMP8) model of Alzheimer’s disease.
...Methods:
7-month-old male senescence resistant mouse strain 1 (SAMR1) and SAMP8 mice were assigned to the following groups, with 15 animals in each group: SAMR1 control (Rc), SAMP8 control (Pc), SAMP8 acupuncture (Pa), SAMP8 sham-acupuncture (Psa). The Pa group was given acupuncture treatment once daily for 15 days. Neuromuscular coordination and cognitive function of the mice were evaluated by the tightrope test and Morris water maze test, respectively. The number of neurons in the CA1, CA3 and dentate gyrus (DG) regions of the hippocampus were measured. The levels of oxidative stress and protein carbonyl, mRNA and protein expression levels of Hsp84 and Hsp86 in the hippocampus were detected.
Results:
Compared with the Rc group, in the Pc mice there was a lower success rate for the tightrope test, impaired cognitive abilities, a decline in neuron numbers, reduced levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), increased levels of superoxide anion and protein carbonyl, and decreased mRNA and protein levels of Hsp84 and Hsp86 (all P<0.05). After acupuncture treatment, the success rate for the tightrope test was elevated, cognitive function was improved, neuron numbers were enhanced, levels of SOD and GSH-Px were increased, levels of superoxide anion and protein carbonyl were decreased, and Hsp84 and Hsp86 mRNA and protein expression were increased in the Pa mice when compared with the Pc and Psa groups (all P<0.05).
Conclusion:
Acupuncture may delay brain ageing in SAMP8 mice by reducing oxidative protein damage and promoting Hsp84 and Hsp86 expression.
Research background: With the development of science and technology and the intelligence of the construction industry, the traditional extensive construction method can no longer meet the social ...demand for safety, which requires the construction enterprises and construction units to constantly change the safety management mode. With the advancement of urbanization, intelligent management and control has become the future development direction of the construction industry, and BIM software has also become an important synchronization platform, which will continuously improve the promotion of the overall project and the management of construction safety. Research methods: This paper mainly uses literature survey, quantitative and qualitative analysis, empirical analysis and other methods, which can study the construction safety management and intelligent management and control as a whole. Through literature survey, this paper has obtained a large amount of literature, which can enrich theoretical analysis and comprehensively understand the current construction safety management mode and intelligent management and control mode. Through relevant theories, this paper can fully demonstrate the follow-up research and empirical analysis. Through quantitative and qualitative analysis method, this paper can use statistical analysis method to analyze construction safety accident data, which will analyze the internal relationship through relevant software. Therefore, the quantitative and qualitative analysis method provides important data support for the subsequent research, which can provide statistical methods for the analysis of building safety hazard sources. Through the empirical simulation method, this paper can analyze specific projects with real cases, which will truly simulate the intelligent monitoring system. Through the empirical simulation method, this paper can verify the scientific nature of the algorithm, and can also demonstrate the management and control mode of the intelligent monitoring system. Research conclusion: Through BIM and RFID, this paper builds an intelligent monitoring system, which also builds the information collection, processing and application stages of the overall framework, and realizes the intelligent management and control of the future construction safety.
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