Major depresif bozuklukta prolidaz aktivitesi Demir, Süleyman; Dicle Üniversitesi Tıp Fakültesi Psikiyatri AD, Diyarbakır, Türkiye; İbiloğlu, Aslıhan Okan; Dicle Üniversitesi Tıp Fakültesi Psikiyatri AD, Diyarbakır, Türkiye; Güneş, Mehmet; Dicle Üniversitesi Tıp Fakültesi Psikiyatri AD, Diyarbakır, Türkiye ...
Journal of clinical and experimental investigations,
09/2015
Journal Article
Objective: Prolidase enzyme, which exists in plasma, brain and various organs, is a cytosolic exopeptidase, that divisor the imidodipeptides with carboxyl terminal position of proline and ...hydroxyproline. The aim of the present study was to investigate serum prolidase activity level in major depressive disorder (MDD).Methods: This study included 22 patients with MDD as the study group, and 26 healthy subjects without any psychiatric disorders as the control group. Each patient underwent a detailed diagnostic evaluation by experienced psychiatrists. The sociodemographic information form given to both patients and the control subjects, while Hamilton Depression Scale Scoring (HDS), Hamilton Anxiety Scale Scoring (HAS), Clinical Global Impression Scoring (CGI) applied to patients. Blood samples were obtained for biochemical analyses.Results: The mean age of the patient group was 31.3±10.1 years old, whereas the mean age of the control group was 32.3±8.8 years old. The mean duration of the education for the patient group was 8.1±6.2 years, whereas for the control group was 10.2±3.8 years. There was no significant differences in terms of the mean age of participants and the mean duration of the education between two groups (p>0.05). The level of prolidase activity of patient group was 510.3±480.8 U/L, whereas the level of prolidase activity of control group was 457.8±386.0 U/L. No significant difference was observed in serum prolidase activity between patient and the control groups (p>0.05). Conclusion: In our study similar level of prolidase activity was found in MDD and healthy subjects. We suggest that this finding may be an evidence indicating that MDD and bipolar depression may be different clinical entities. J Clin Exp Invest 2015; 6 (3): 296-300
Amaç: Prolidaz enzimi dipeptitlerin karboksil terminal pozisyondaki prolin veya hidroksiprolini ayıran plazma, beyin ve çeşitli organlarda bulunan bir egzopeptidazdır. Biz bu çalışmada major depresif bozukluk (MDB)’da prolidaz aktivitesini araştırmayı amaçladık.Yöntemler: Çalışmamızda hasta grubu major depresif bozukluk 22 kişiden oluşurken kontrol grubu ise herhangi bir psikiyatrik rahatsızlığı olmayan sağlıklı 26 kişiden oluşmaktaydı. Her hasta deneyimli psikiyatristler tarafından ayrıntılı tanısal değerlendirmeye alındı. Hasta ve kontrol grubuna sosyodemografik bilgi formu verilirken, hasta grubuna Hamilton Depresyon Derecelendirme Ölçeği (HDDÖ), Hamilton Anksiyete Derecelendirme Ölçeği (HADÖ), Klinik Global İzlem Ölçeği (KGİ) uygulandı. Biyokimyasal analizler için kan alındı.Bulgular: Hasta grubunun yaş ortalaması 31,3±10,1 yıl, kontrol grubunun yaş ortalaması ise 32,3±8,8 yıl idi. Eğitim süresi hasta grubunun 8,1±6,2 yıl, kontrol grubunda 10,2±3,8 yıl idi. Gruplar arasında yaş ve eğitim süresi açısından istatistiksel olarak anlamlı farklılık belirlenmedi (p>0,05). Prolidaz aktivitesinin hasta grubunda 510.3±480.8 U/L iken kontrol grubunda 457,8±386,0 U/L olduğu görüldü. Prolidaz aktivitesi bakımında hasta ve kontrol grubu arasında anlamlı farklılık gözlenmedi (p>0,05).Sonuç: Çalışmamızda prolidaz aktivitesi MDB’ta sağlıklı kişilerle benzer bulunmuştur. Bu verinin MDB ve bipolar depresyonun farklı klinik antiteler olduğunu biyokimyasal düzeyde gösteren bir bulgu olabileceğini önermekteyiz.Anahtar kelimeler: Major depresif bozukluk, prolidaz aktivitesi, etyoloji
An experience of domestic violence can lead to permanent physical, mental, and psychological harms, whether the child is a direct victim or a witness. Although having no standard definition, it is ...generally agreed that childhood sexual abuse and incest are underreported. The majority of sexual abuse happens in childhood, with incest being the most common form. Incest is a sexual activity or assault between family members or close relatives and can be defined as the sexual abuse of the child, as well. On the other hand, pedophilic disorder is defined as having recurrent, intense sexual urges or behaviors involving sexual activity with a preadolescent child, over a period of at least 6 months. In this article, clinical, social, and legal effects from the sexual abuse of results are investigated. Results of our research will be hopefully helpful in informing social policy and guiding mental health practice.
Domestic violence is passed from one generation to the next, and it affects not only the victim but also the psychological states of the witnesses, and especially the psychosocial development of ...children. Studies have reported that those who have been the victim of or witnessing violence during their childhood will use violence to a greater extent as adults in their own families. This research examines the relationships between a history of childhood physical abuse, likelihood of psychiatric diagnoses, and potential for being a perpetrator of childhood physical abuse in adulthood among women who received psychiatric treatment and in the healthy population from Turkey. Estimates of the prevalence of childhood physical abuse vary depending on definition and setting. The frequency of witnessing and undergoing physical abuse within the family during childhood is much higher in the psychiatrically disordered group than the healthy controls. Childhood physical abuse history is one of the major risk factors for being an abuser in adulthood. The best indicator of physically abusing one’s own children was found to be as physical abuse during the childhood period rather than psychiatric diagnosis. There is a large body of research indicating that adults who have been abused as children are more likely to abuse their own children than adults without this history. This is an important study from the point of view that consequences of violence can span generations. Further studies with different risk factor and populations will help to identify different dimensions of the problem.
Deliberate self-harm or self-injurious behaviors (SIB) defined as 'the intentional, direct injuring of body tissue without suicidal intent' in addition to this topic has generated mounting interest ...among mental health professionals, over the past years. Psychiatric disordered patients have the tendency to self-harm repeatedly. We report here, a case that was referred for SIB with deliberately inserted needles in her body, over the last 12 years. (Anatolian Journal of Psychiatry 2016; 17(Suppl.3):38-40) Keywords: self-injurious behaviour, foreign body, stressful life events, impulsivity Intihar niyeti olmadan kasitli olarak kendi vucuduna dogrudan zarar verme olarak tanimlanan "kasitli olarak kendine zarar verme veya kendini yaralama davranisi", son yillarda ruh sagligi profesyonelleri arasinda giderek daha cok ilgi cekmektedir. Psikiyatrik bozuklugu olan hastalarin tekrarlayan bicimde kendine zarar verme egilimleri vardir. Biz burada yaklasik 12 yildir, kasitli olarak kendi vucuduna igne yerlestirerek, kendini yaralama davranisi olan bir olguyu sunuyoruz. (Anadolu Psikiyatri Derg 2016; 17(Ek.3):38-40) Anahtar sozcukler: Kendini yaralama davranisi, yabanci cisim, olumsuz yasam olaylari, durtusellik
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