The prognosis of hepatocellular carcinoma (HCC) patients remains poor. Identifying prognostic markers to stratify HCC patients might help to improve their outcomes.
Six gene expression profiles ...(GSE121248, GSE84402, GSE65372, GSE51401, GSE45267 and GSE14520) were obtained for differentially expressed genes (DEGs) analysis between HCC tissues and non-tumor tissues. To identify the prognostic genes and establish risk score model, univariable Cox regression survival analysis and Lasso-penalized Cox regression analysis were performed based on the integrated DEGs by robust rank aggregation method. Then Kaplan-Meier and time-dependent receiver operating characteristic (ROC) curves were generated to validate the prognostic performance of risk score in training datasets and validation datasets. Multivariable Cox regression analysis was used to identify independent prognostic factors in liver cancer. A prognostic nomogram was constructed based on The Cancer Genome Atlas (TCGA) dataset. Finally, the correlation between DNA methylation and prognosis-related genes was analyzed.
A twelve-gene signature including SPP1, KIF20A, HMMR, TPX2, LAPTM4B, TTK, MAGEA6, ANX10, LECT2, CYP2C9, RDH16 and LCAT was identified, and risk score was calculated by corresponding coefficients. The risk score model showed a strong diagnosis performance to distinguish HCC from normal samples. The HCC patients were stratified into high-risk and low-risk group based on the cutoff value of risk score. The Kaplan-Meier survival curves revealed significantly favorable overall survival in groups with lower risk score (P < 0.0001). Time-dependent ROC analysis showed well prognostic performance of the twelve-gene signature, which was comparable or superior to AJCC stage at predicting 1-, 3-, and 5-year overall survival. In addition, the twelve-gene signature was independent with other clinical factors and performed better in predicting overall survival after combining with age and AJCC stage by nomogram. Moreover, most of the prognostic twelve genes were negatively correlated with DNA methylation in HCC tissues, which SPP1 and LCAT were identified as the DNA methylation-driven genes.
We identified a twelve-gene signature as a robust marker with great potential for clinical application in risk stratification and overall survival prediction in HCC patients.
Background
The global burden of gallbladder and biliary tract cancer (GBTC) is increasing. A comprehensive evaluation of the burden is crucial to improve strategies for GBTC prevention and treatment.
...Methods
The incidence rates, mortality, and disability‐adjusted life years (DALYs) of GBTC from 1990 to 2017 were extracted from the Global Burden of Diseases Study (GBD) 2017. Estimated annual percent changes (EAPCs) were calculated to quantify GBTC trends during the study period.
Results
Globally, there were 210,878 new cases, 173,974 deaths, and 3,483,046 DALYs because of GBTC in 2017. GBTC incidence increased by 76%, mortality increased by 65%, and DALYs increased by 52% from 1990 to 2017. In addition, relatively higher Socio‐Demographic Index regions had greater incidence and death rates but greatly decreased age‐standardized incidence rate (ASIR) and age‐standardized death rate (ASDR). At the national level, Chile had the highest ASIR (10.38 per 100,000 population) and the highest ASDR (10.43 per 100,000 population) in 2017. The largest increases in ASIR (EAPC, 3.38) and ASDR (EAPC, 3.39) were observed in Georgia. Nonlinear associations were observed between the ASDR, the Socio‐Demographic Index, and DALYs at the 21 GBD regional levels and at the national level. The proportions of GBTC age‐standardized deaths and DALYs attributable to high body mass index were 15.4% and 16%, respectively.
Conclusions
GBTC remains a major health burden worldwide. These findings are expected to prompt policymakers to establish a cost‐effective method for the early diagnosis, prevention, and treatment of GBTC, reducing its modifiable risk factors and reversing its increasing trends.
Lay Summary
Although the rates of age‐standardized incidence, death, and disability‐adjusted life‐years for gallbladder and biliary tract cancer decreased from 1990 to 2017, the numbers of these measures increased.
Nonlinear associations existed between the age‐standardized death rate, the Socio‐Demographic Index, and disability‐adjusted life‐years at the 21 regional and national levels in the Global Burden of Disease Study.
Gallbladder and biliary tract cancer (GBTC) remains a major health burden worldwide; however, the burden of GBTC varies geographically. Establishing a cost‐effective method for the early diagnosis, prevention, and treatment of GBTC, reducing its modifiable risk factors, and reversing the increasing trend are warranted to reduce the GBTC burden.
Pancreatitis is a critical public health problem, and the burden of pancreatitis is increasing. We report the rates and trends of the prevalence, incidence, and years lived with disability (YLDs) for ...pancreatitis at the global, regional, and national levels in 195 countries and territories from 1990 to 2017, stratified by sex, age, and sociodemographic index (SDI).
Data on pancreatitis were available from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017. Numbers and age-standardized prevalence, incidence, and YLDs' rates per 100,000 population were estimated through a systematic analysis of modeled data from the 2017 GBD study. Both acute and chronic pancreatitis are being modeled separately in the GBD 2017; however, our data show acute and chronic pancreatitis together. Estimates were reported with uncertainty intervals (UIs).
Globally, in 2017, the age-standardized rates were 76.2 (95% UIs 68.9 to 83.4), 20.6 (19.2 to 22.1), and 4.5 (2.3 to 7.6) per 100,000 population for the point prevalence, incidence, and YLDs, respectively. From 1990 to 2017, the percent changes in the age-standardized prevalence and YLDs rates increased, whereas the age-standardized incidence rate decreased. The global prevalence increased with age up to 60-64 years and 44-49 years in females and males, respectively, and then decreased, with no significant difference between females and males. The global prevalence rate increased with age, peaking in the 95+ age group, with no difference between sexes. Generally, positive correlation between age-standardized YLDs and SDIs at the regional and national levels was observed. Slovakia (297.7 273.4 to 325.3), Belgium (274.3 242.6 to 306.5), and Poland (266.7 248.2 to 284.4) had the highest age-standardized prevalence rates in 2017. Taiwan (Province of China) (104.2% 94.8 to 115.2%), Maldives (72.4% 66.5 to 79.2%), and Iceland (64.8% 57.2 to 72.9%) had the largest increases in age-standardized prevalence rates from 1990 to 2017.
Pancreatitis is a major public health issue worldwide. The age-standardized prevalence and YLDs rates increased, but the age-standardized incidence rate decreased from 1990 to 2017. Improving the quality of pancreatitis health data in all regions and countries is strongly recommended for better monitoring the burden of pancreatitis.
Appendicitis is the most common abdominal surgical emergency worldwide, and its burden has been changing. We report the level and trends of appendicitis prevalence, and incidence; and years lived ...with disability (YLD) in 204 countries and territories from 1990 to 2019, based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.
The numbers and age-standardized prevalence, incidence, and YLD rates per 100,000 population of appendicitis were estimated across regions and countries by age, sex, and sociodemographic index (SDI). All the estimates were reported with 95% uncertainty intervals (UIs).
Globally, the age-standardized prevalence and incidence rates of appendicitis in 2019 were 8.7 (95% UI 6.9 to 11.0) and 229.9 (95% UI 180.9 to 291.0) per 100,000 population, with increases of 20.8% (95% UI 18.9 to 23.0%) and 20.5% (95% UI 18.7 to 22.8%) from 1990 to 2019, respectively. Additionally, the age-standardized YLDs rate was 2.7 (95% UI 1.8 to 3.9) in 2019, with an increase of 20.4% (95% UI 16.2 to 25.1%) from 1990 to 2019. In 2019, the age-standardized prevalence, incidence, and YLD rates peaked in the 15-to-19-year age groups in both male and female individuals. However, no statistically significant differences were observed between the male and female individuals in all groups. Ethiopia, India, and Nigeria showed the largest increases in the age-standardized prevalence rate between 1990 and 2019. Generally, positive associations were found between the age-standardized YLD rates and SDI at the regional and national levels.
Appendicitis remains a major public health challenge globally. Increasing awareness of appendicitis and its risk factors and the importance of early diagnosis and treatment is warranted to reduce its the burden.
Rice is a major food supply in southeast China. With increased population and urbanization, reliable rice mapping is critical in this region. Because of frequent cloud cover and precipitation during ...the rice-growing season, it is difficult to conduct large-area rice monitoring with optical remote sensing techniques. L-band synthetic aperture radar (SAR), with its all-weather day and night imaging and canopy penetration capabilities, provides a unique alternative. In this study, a first-order radiative transfer model was developed to simulate L-band scattering properties of paddy rice. Three Advanced Land Observing Satellite (ALOS)/Phased-Array-Type L-band Synthetic Aperture Radar (PALSAR) images in dual-polarization mode (HH and HV) acquired in early tillering (June 28, 2007), tillering (August 13, 2007), and heading (September 28, 2007) stages were processed to test the temporal variation of rice backscatter. It was found that plant height and leaf mass amount were the two major structural parameters that contributed to rice backscatter in PALSAR images. The variation of the simulated HH backscatter matched with PALSAR observations in sample fields, although the simulated backscatter coefficients were around 3 dB lower than image-extracted values. Leaf volume scattering and leaf-ground double bounce were found as the two major scattering components in L-band HH polarization and increased with leaf layer height and density. This paper demonstrated that L-band HH backscatter was more sensitive to rice's structural variation than the VV backscatter and may therefore be more useful in rice mapping and modeling studies.
Background
Liver cancer is one of the most common cancers worldwide. We aimed to report the burden of liver cancer at the global, regional, and national levels in 204 countries from 1990 to 2019, ...stratified by etiology, sex, age, and sociodemographic index (SDI).
Methods
Data of mortality, incidence, and disability‐adjusted life years (DALYs) of liver cancer and its etiology were available from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2019. The trends in the liver cancer burden were assessed by the annual percentage change. All estimates are presented as numbers and age‐standardized rates (ASRs) per 100,000 population, with uncertainty intervals (UIs).
Results
Globally, 484,577 (95% UI 444,091–525,798) mortalities, 534,364 (486,550–588,639) incident cases, and 12,528,422 (11,400,671–13,687,675) disability‐adjusted life years (DALYs) due to liver cancer occurred in 2019. The ASRs were 5.95 (5.44–6.44), 6.51 (5.95–7.16), and 151.08 (137.53–164.8) per 100,000 population for the mortalities, incidences, and DALYs, respectively. From 1990 to 2019, the numbers increased, whereas the ASRs decreased. Hepatitis B and Hepatitis C are the major causes of liver cancer mortality. The liver cancer mortality in 2019 increased with age, peaking at 65–69 and 70–74 age group in males and females, respectively, and the number was higher in males than in females. Generally, there were nonlinear associations between the ASR and SDIs values at the regional and national levels. China had the highest numbers of mortalities, incident cases, and DALYs, whereas Mongolia has the highest ASR in 2019.
Conclusion
Liver cancer remains a major public health issue worldwide, but etiological and geographical variations exist. It is necessary to increase awareness of the population regarding liver cancer, its etiologies and the importance of early detection, and diagnosis and treatment.
Liver cancer is one of the most common cancers worldwide. We aim to report the burden of liver cancer at the global, regional, and national levels in 204 countries from 1990 to 2019, stratified by etiology, sex, age, and sociodemographic index (SDI). Liver cancer remains a major public health issue worldwide, but there are etiological and geographical variations. Increasing the awareness of the population regarding liver cancer, its etiologies and the importance of early detection, and diagnosis and treatment are needed.
We apply the so-called multiplicative regularized Gauss-Newton inversion algorithm for solving three-dimensional electromagnetic microwave inverse problems. This inversion algorithm automatically ...adjusts the regularization parameter and when combined with the total variation type regularization function, it can provide inversion results with excellent edge-preserving characteristics. In addition, in order to deal with an extensive memory requirement for the Gauss-Newton method, we employ an implicit Jacobian calculation scheme. By using this scheme we do not have to explicitly store the Jacobian matrix. Hence, we are able to significantly reduce the memory requirement of the Gauss-Newton method albeit at an additional computational overhead. Furthermore, in order to be able to handle a large scale computational problem, both the forward and the inversion algorithms are parallelized using the MPI library, where we obtain a nearly linear speedup factor. We demonstrate efficiency and robustness of this algorithm by inverting synthetic data, Fresnel experimental data, and biomedical experimental data.
A novel CFS composite wall filled with cement-based lightweight polymer material (CFS-CLPM composite wall) has been proposed and proven to have excellent architectural and mechanical performance. To ...promote its application in prefabricated concrete (PC) frame structures, two full-scale specimens were designed and tested under cyclic loading to investigate the failure mode, hysteretic response and energy dissipation of the PC frame infilled with the CFS-CLPM composite wall. The experimental results indicated that CFS-CLPM composite walls can significantly improve the lateral behavior of the PC frame in terms of load capacity, elastic stiffness and energy dissipation capacity, while slightly reducing its ductility because of the infill-frame interaction. Subsequently, finite element (FE) analyses for the PC frame infilled with CFS-CLPM composite walls were developed and verified against the experimental results. The force-transferring mechanisms between the PC frame and the CFS-CLPM composite walls were revealed by analyzing the stress distributions. The parametric analyses demonstrated that the influential parameters for lateral resistances of the PC frame structure infilled with CFS-CLPM composite walls were the strength of CLPM, the span-to-height ratio and the thickness of CFS-CLPM composite walls. Finally, a formula considering the mechanical contribution of the CFS-CLPM composite wall was proposed to predict the elastic lateral stiffness of the structures. The results of this study could provide a basis for the application of CFS-CLPM composite walls in PC frame structures.
As a lead-free perovskite, CsBi
3
I
10
has attracted significant attention because of its high thermal tolerance and long electron diffusion length. Solution-processed high-performance CsBi
3
I
10
...perovskite devices, however, are hindered by the formation of a two-dimensional structure, which results in an extremely high surface roughness and many pinholes. In this paper, we reported a space-confined growth (SCG) method using a single-layer polystyrene (PS) sphere template to obtain high-smoothness, high-crystallinity, and dense CsBi
3
I
10
perovskite films. Compared with traditionally spin-coated CsBi
3
I
10
photodetectors (PDs), the metal-semiconductor-metal PDs made by SCG showed a higher photocurrent, a lower dark current, and a bigger on/off ratio. In addition, the photocurrent of our unencapsulated CsBi
3
I
10
perovskite PDs was not attenuated under long-time illumination. In addition, when the device was stored in air for 30 d, its performance also showed no degradation, demonstrating ultra-high stability. Furthermore, the synthesis was free of antisolvents, such as chlorobenzene and toluene, which is beneficial for the environmentally friendly assembly of the devices. Our strategy opens up a new way to prepare high-quality lead-free perovskite, which may be useful for applications in light-emitting diodes and solar cells.
A numerical method for performing detailed investigations of modulation effects in sea backscattering is presented. The method is based on a combination of numerical hydrodynamic and electromagnetic ...codes as well as repeated simulations as the spectral content of the sea surface is varied. The results obtained can be useful in separating ldquotiltrdquo and hydrodynamic modulations in computed sea backscattering cross sections, and help to provide some insight into the need for ldquothree-scalerdquo modeling of sea surface returns. Sample results are presented to illustrate the basic process.
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