To look for new active constituents from the aerial part of Cimicifuga foetida L.
Various column chromatographic techniques were used for the isolation and purification of the ingredients. The ...structure were elucidated on the basis of spectral evidences and chemical reaction.
Five compounds were obtained and identified as 23-O-acetylshengmanol-3-O-alpha-L-arabinopyranoside (1), 23-O-acetylshengmanol-3-O-beta-D-xylopyranoside (2), 25-anhydrocimigenol-3-O-beta-D-xylopyranoside (3), cimigenol-3-O-alpha-L-arabinopyranoside (4), cimigenol-3-O-beta-D-xylopyranoside (5).
Compound 1 is a new compound, and compounds 2 and 4 were isolated from this plant for the first time.
Factors such as environmental change during space flight have the widespread influences on physical and mental health, causing aerospace medical problems like cardiovascular dysfunction. One of its ...manifestations of cardiovascular disorders is orthostatic intolerance. At present, these measures to protect against the physiological effects of weightlessness provide a protective effect, but still cannot completely eliminate the adverse effects of weightlessness on cardiovascular system. Therefore, it is very necessary to find a convenient and effective protective countermeasures. Clinical practice and modern experimental research have revealed that acupuncture and moxibustion has very good regulating effect on cardiovascular system. However, until now, there is no unified stimulus standard (such as stimulus frequency, time etc), which seriously affects the repeatability of operation and the efficacy of acupuncture. Therefore it's very important to set a repeatable standard.
We perform decoy-state quantum key distribution between a low-Earth-orbit satellite and multiple ground stations located in Xinglong, Nanshan, and Graz, which establish satellite-to-ground secure ...keys with ~kHz rate per passage of the satellite Micius over a ground station. The satellite thus establishes a secure key between itself and, say, Xinglong, and another key between itself and, say, Graz. Then, upon request from the ground command, Micius acts as a trusted relay. It performs bitwise exclusive OR operations between the two keys and relays the result to one of the ground stations. That way, a secret key is created between China and Europe at locations separated by 7600 km on Earth. These keys are then used for intercontinental quantum-secured communication. This was on the one hand the transmission of images in a one-time pad configuration from China to Austria as well as from Austria to China. Also, a videoconference was performed between the Austrian Academy of Sciences and the Chinese Academy of Sciences, which also included a 280 km optical ground connection between Xinglong and Beijing. Our work points towards an efficient solution for an ultralong-distance global quantum network, laying the groundwork for a future quantum internet.
Quantum key distribution (QKD) uses individual light quanta in quantum superposition states to guarantee unconditional communication security between distant parties. In practice, the achievable ...distance for QKD has been limited to a few hundred kilometers, due to the channel loss of fibers or terrestrial free space that exponentially reduced the photon rate. Satellite-based QKD promises to establish a global-scale quantum network by exploiting the negligible photon loss and decoherence in the empty out space. Here, we develop and launch a low-Earth-orbit satellite to implement decoy-state QKD with over kHz key rate from the satellite to ground over a distance up to 1200 km, which is up to 20 orders of magnitudes more efficient than that expected using an optical fiber (with 0.2 dB/km loss) of the same length. The establishment of a reliable and efficient space-to-ground link for faithful quantum state transmission constitutes a key milestone for global-scale quantum networks.
Plane-pair partial element equivalent circuit (PEEC) (PPP) is a faster analytical method for calculating the impedance properties of plane-pairs PDN structure. In this paper, PPP method is employed ...to simulate the loop inductance of multi-slots plane-pair structure. The influence of slots fill area ratio on loop inductance is studied. The experimental work is carried out and the results agree well with the simulated ones.
Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of
Cimicifuga foetida on various cancer cell lines. In the present study, we investigated the cytotoxicity of five ...cycloartane triterpenoids isolated from the EtOAc fraction. Compounds (
1,2,3) showed moderate cytotoxic activity on R-HepG2 cells and drug resistant sub line R-HepG2 but exhibited less toxicity against primary cultured normal mouse hepatocytes. Compounds (
4) and (
5) were inactive on all tested cell lines.
Bovine whey protein expression patterns of colostrum are much different from that of milk. Moreover, bovine colostrum is an important source of protective, nutritional and developmental factors for ...the newborn. However, to our knowledge, no research has been performed to date using a comparative proteomic method on the changes in the bovine whey proteome during the transition from colostrum to milk. This study therefore separated whey protein of days 1, 3, 7 and 21 after calving using two dimension electrophoresis. Differentially expressed proteins at different collection times were identified using high-performance liquid chromatography in tandem with mass spectrometry (LC/MS) and validated by enzyme-linked immunosorbent assay (ELISA) in order to understand the developmental changes in the bovine whey proteome during the transition from colostrum to milk. The expression patterns of whey protein of days 1 and 3 post-partum were similar except that immunoglobulin G was down-regulated on day 3, and four proteins were found to be down-regulated on days 7 and 21 compared with day 1 after delivering, including immunoglobulin G, immunoglobulin M, albumin, and lactotransferrin, which are involved in immunity and molecule transport. The results of this study confirm the comparative proteomic method has the advantage over other methods such as ELISA and immunoassays in that it can simultaneously detect more differentially expressed proteins. In addition, the difference in composition of milk indicates a need for adjustment of the colostrum feeding regimen to ensure a protective immunological status for newborn calves.
To find new active constituents from the aerial part of Cimicifuga foetida.
Various column chromatographic techniques were used for the isolation and purification of the principles. The structures ...were elucidated on the basis of spectral data and chemical evidences.
Four 9,19-cycloartane triterpenoid saponins were obtained and identified as Cimifoetiside III (25-anhydrocimigenol-3-O-beta-D-galactopyranoside, 1), 25-O-acetyl-cimigenol xylopyranoside (2), 25-O-acetyl-cimigenol galactopyranoside (3), 7 beta-hydrocimigenol xylopyranoside (4).
Compound 1 is new and compound 4 was isolated from this plant for the first time.
