PurposeDrawing on the literature on entrepreneurial intention (EI), this paper develops and tests a model that aims to explain student EI by considering the valuation of entrepreneurship and the ...venture failure stigmatization in the closer environment of the respondent and the role of individual entrepreneurial orientation (IEO) through direct and indirect effects.Design/methodology/approachThe paper uses a survey method for data collection. As such, this study was conducted by considering a sample of 1,155 undergraduate students from different majors. Structural equation modeling is used to validate the theoretical model.FindingsThe findings suggest that a positive closer valuation of entrepreneurship facilitates students' EI. In turn, a closer stigma of entrepreneurial failure hinders students' EI. More importantly, IEO has a significant mediating role in both of these relationships. The findings offer important theoretical and practical implications for the field of entrepreneurship education and entrepreneurial behavior.Originality/valueThe paper offers a new insight relating environmental cognitive elements and their impact on EI, besides how IEO represents a determinant role shaping these relations. The proposed model is original and makes a connection between two widely validated constructs and evidences the relationship that may exist between the orientation and the real intention of setting up a business. Moreover, IEO has rarely been addressed for verifying interaction effects. This paper is one of the very first studies that applies the IEO (individual-level of entrepreneurial orientation) as a mediating variable.
We report on the possibility of detecting hinge spin polarization in magnetic topological insulators by resistance measurements. By implementing a three-dimensional model of magnetic topological ...insulators into a multiterminal device with ferromagnetic contacts near the top surface, local spin features of the chiral edge modes are unveiled. We find local spin polarization at the hinges that inverts the sign between the top and bottom surfaces. At the opposite edge, the topological state with inverted spin polarization propagates in the reverse direction. A large resistance switch between forward and backward propagating states is obtained, driven by the matching between the spin polarized hinges and the ferromagnetic contacts. This feature is general to the ferromagnetic, antiferromagnetic, and canted antiferromagnetic phases, and enables the design of spin-sensitive devices, with the possibility of reversing the hinge spin polarization of the currents.
Petroleum‐based plastics are durable and accumulate in all ecological niches. Knowledge on enzymatic degradation is sparse. Today, less than 50 verified plastics‐active enzymes are known. First ...examples of enzymes acting on the polymers polyethylene terephthalate (PET) and polyurethane (PUR) have been reported together with a detailed biochemical and structural description. Furthermore, very few polyamide (PA) oligomer active enzymes are known. In this article, the current known enzymes acting on the synthetic polymers PET and PUR are briefly summarized, their published activity data were collected and integrated into a comprehensive open access database. The Plastics‐Active Enzymes Database (PAZy) represents an inventory of known and experimentally verified enzymes that act on synthetic fossil fuel‐based polymers. Almost 3000 homologs of PET‐active enzymes were identified by profile hidden Markov models. Over 2000 homologs of PUR‐active enzymes were identified by BLAST. Based on multiple sequence alignments, conservation analysis identified the most conserved amino acids, and sequence motifs for PET‐ and PUR‐active enzymes were derived.
Global economies depend on the use of fossil‐fuel‐based polymers with 360–400 million metric tons of synthetic polymers being produced per year. Unfortunately, an estimated 60% of the global ...production is disposed into the environment. Within this framework, microbiologists have tried to identify plastic‐active enzymes over the past decade. Until now, this research has largely failed to deliver functional biocatalysts acting on the commodity polymers such as polyethylene (PE), polypropylene (PP), polyvinylchloride (PVC), ether‐based polyurethane (PUR), polyamide (PA), polystyrene (PS) and synthetic rubber (SR). However, few enzymes are known to act on low‐density and low‐crystalline (amorphous) polyethylene terephthalate (PET) and ester‐based PUR. These above‐mentioned polymers represent >95% of all synthetic plastics produced. Therefore, the main challenge microbiologists are currently facing is in finding polymer‐active enzymes targeting the majority of fossil‐fuel‐based plastics. However, identifying plastic‐active enzymes either to implement them in biotechnological processes or to understand their potential role in nature is an emerging research field. The application of these enzymes is still in its infancy. Here, we summarize the current knowledge on microbial plastic‐active enzymes, their global distribution and potential impact on plastic degradation in industrial processes and nature. We further outline major challenges in finding novel plastic‐active enzymes, optimizing known ones by synthetic approaches and problems arising through falsely annotated and unfiltered use of database entries. Finally, we highlight potential biotechnological applications and possible re‐ and upcycling concepts using microorganisms.
Plastics pollute the environment at all levels. Until now, microbiologist largely failed delivering functional biocatalysts acting on most of the the commodity polymers Therefore, identifying plastic‐active enzymes either to implement them in biotechnological processes or to understand their potential role in nature is an emerging research field. Here summarize knowledge on available enzymes and technologies to used for mining novel enzymes.
In this brief, a linear-based battery charger is proposed, designed, fabricated in a 180 nm SOI process, and measured. The design is aimed to charge low-power wearable or implantable medical devices ...through a wireless power transfer (WPT) link at a transfer distance of several centimeters, where the available power is in the range of a few milliwatts. A novel self-turn-on/off circuit was implemented, preventing quiescent power consumption while the WPT link is inactive. The compact proposed circuit requires a remarkable low chip area of 0.023 mm 2 . In measurements, using a 3.7 V (nominal) lithium-Ion battery, a configurable charging current from 500 <inline-formula> <tex-math notation="LaTeX">\mu \text{A} </tex-math></inline-formula> to 20 mA was achieved, while presenting a competitive efficiency with the state-of-the-art. The automatic transition between the constant current (CC) and constant voltage (CV) charging phases is shown in measurements.
Studying giant star-forming clumps in distant galaxies is important to understand galaxy formation and evolution. At present, however, observers and theorists have not reached a consensus on whether ...the observed "clumps" in distant galaxies are the same phenomenon that is seen in simulations. In this paper, as a step to establish a benchmark of direct comparisons between observations and theories, we publish a sample of clumps constructed to represent the commonly observed "clumps" in the literature. This sample contains 3193 clumps detected from 1270 galaxies at 0.5 ≤ z < 3.0 . The clumps are detected from rest-frame UV images, as described in our previous paper. Their physical properties (e.g., rest-frame color, stellar mass ( M * ), star formation rate (SFR), age, and dust extinction) are measured by fitting the spectral energy distribution (SED) to synthetic stellar population models. We carefully test the procedures of measuring clump properties, especially the method of subtracting background fluxes from the diffuse component of galaxies. With our fiducial background subtraction, we find a radial clump U − V color variation, where clumps close to galactic centers are redder than those in outskirts. The slope of the color gradient (clump color as a function of their galactocentric distance scaled by the semimajor axis of galaxies) changes with redshift and M * of the host galaxies: at a fixed M * , the slope becomes steeper toward low redshift, and at a fixed redshift, it becomes slightly steeper with M * . Based on our SED fitting, this observed color gradient can be explained by a combination of a negative age gradient, a negative E(B − V) gradient, and a positive specific SFR gradient of the clumps. We also find that the color gradients of clumps are steeper than those of intra-clump regions. Correspondingly, the radial gradients of the derived physical properties of clumps are different from those of the diffuse component or intra-clump regions.
Scope
Dysbiosis of gut microbiota is involved in metabolic syndrome (MetS) development, which has a different incidence between men (M) and women (W). The differences in gut microbiota in MetS ...patients are explored according to gender, and whether consuming two healthy diets, Mediterranean (MED) and low‐fat (LF), may, over time, differentially shape the gut microbiota dysbiosis according to gender is evaluated.
Materials and Methods
All the women from the CORDIOPREV study whose feces samples were available and a similar number of men, matched by the main metabolic variables (N = 246, 123 women and 123 men), and categorized according to the presence or not of MetS are included. Gut microbiota is analyzed at baseline and after 3 years of dietary intervention.
Results
Higher abundance of Collinsella, Alistipes, Anaerotruncus, and Phascolarctobacterium genera is observed in MetS‐W than in MetS‐M, whereas the abundance of Faecalibacterium and Prevotella genera is higher in MetS‐M than in MetS‐W. Moreover, higher levels of Desulfovibrio, Roseburia, and Holdemania are observed in men than in women after the consumption of the LF diet.
Conclusion
The results suggest the potential involvement of differences in gut microbiota in the unequal incidence of metabolic diseases between genders, and a sex‐dependent effect on shaping the gut microbiota according to diet.
Dysbiosis of gut microbiota is involved in the development of metabolic syndrome, whose incidence is different between men and women. This work provides evidence of a different gut microbiota composition in metabolic syndrome, according to gender. Moreover, the study shows a differential shaping of the gut microbiota according to the gender in metabolic syndrome patients after the consumption of a Mediterranean or a low‐fat diet for three years.
The KIDMED questionnaire was published in 2004 to evaluate adherence to the Mediterranean diet (MD) in children and adolescents. In the last 14 years, several respected official dietetics and health ...organizations have recommended appropriate dietary habits, including eating whole grains and consuming whole fruit rather than fruit juice. We propose an update of the KIDMED questionnaire.
Based on the scientific evidence, the present commentary suggests some changes to the KIDMED questionnaire.
We suggest deleting 'or fruit juice' from the first question of the questionnaire, rewording the question as 'Takes a fruit every day', and assigning a positive value of +1. We suggest adding 'whole-grain' to the eighth question of the questionnaire, rewording the question as 'Consumes whole-grain pasta or whole-grain rice almost every day (5 or more times per week)', and assigning a positive value of +1. Further, we propose to add 'whole cereals or whole grains' to the ninth question of the questionnaire, reword the question as 'Has whole cereals or whole grains (whole-meal bread, etc.) for breakfast', and assign a positive value of +1.
The present commentary examines some signs of a paradigm shift about fruit juice and whole grains after the development of the KIDMED questionnaire. The changes are of paramount importance in order to make the questionnaire an updated tool to evaluate adherence to the MD.
Team diversity is recognized not only as an equity issue but also a catalyst for improved performance through diversity in knowledge and practices. However, team diversity data in healthcare are ...limited and it is not known whether it may affect outcomes in surgery. This study examined the association between anaesthesia-surgery team sex diversity and postoperative outcomes.
This was a population-based retrospective cohort study of adults undergoing major inpatient procedures between 2009 and 2019. The exposure was the hospital percentage of female anaesthetists and surgeons in the year of surgery. The outcome was 90-day major morbidity. Restricted cubic splines were used to identify a clinically meaningful dichotomization of team sex diversity, with over 35% female anaesthetists and surgeons representing higher diversity. The association with outcomes was examined using multivariable logistic regression.
Of 709 899 index operations performed at 88 hospitals, 90-day major morbidity occurred in 14.4%. The median proportion of female anaesthetists and surgeons was 28 (interquartile range 25-31)% per hospital per year. Care in hospitals with higher sex diversity (over 35% female) was associated with reduced odds of 90-day major morbidity (OR 0.97, 95% c.i. 0.95 to 0.99; P = 0.02) after adjustment. The magnitude of this association was greater for patients treated by female anaesthetists (OR 0.92, 0.88 to 0.97; P = 0.002) and female surgeons (OR 0.83, 0.76 to 0.90; P < 0.001).
Care in hospitals with greater anaesthesia-surgery team sex diversity was associated with better postoperative outcomes. Care in a hospital reaching a critical mass with over 35% female anaesthetists and surgeons, representing higher team sex-diversity, was associated with a 3% lower odds of 90-day major morbidity.
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