Atrial fibrillation (AF) is the most common sustained arrhythmia in women and men worldwide. During the past century, a range of risk factors has been associated with AF, severe complications from ...the arrhythmia have been identified, and its prevalence has been increasing steadily. Whereas evidence has accumulated regarding sex-specific differences in coronary heart disease and stroke, the differences between women and men with AF has received less attention. We review the current literature on sex-specific differences in the epidemiology of AF, including incidence, prevalence, risk factors, and genetics, and in the pathophysiology and the clinical presentation and prognosis of patients with this arrhythmia. We highlight current knowledge gaps and areas that warrant future research, which might advance understanding of variation in the risk factors and complications of AF, and ultimately aid more-tailored management of the arrhythmia.
Androgens are known to exert their effects via genomic signalling, which involves intracellular androgen receptors that modulate gene expression on steroid binding. Whereas non-classical estrogen ...effects are well established, it is only recently that non-classical, rapid, membrane-initiated testosterone actions have received attention. Non-classical effects of testosterone have now been demonstrated convincingly in several tissues, in particular in the reproductive, cardiovascular, immune and musculoskeletal systems. There is evidence for the participation of the classical intracellular androgen receptor and for involvement of novel, membrane-associated androgen receptors in the non-classical actions of testosterone. Here we discuss evidence for rapid testosterone actions, which have clinical implications in fertility, cardiovascular disease and the treatment of prostate cancer.
Abstract This research aimed to obtain empirical evidence about the influence of rotation and competency to motivation non Lecturer in the School of Electrical Engineering and Informatics Bandung ...Institute of Technology. The research results are expected to contribute in the development of management, especially human resource management. The research was conducted at the School of Electrical Engineering and Informatics Bandung Institute of Technology in Bandung, West Java. All the employees are sampled in this research. This research approach is quantitative, whereas the type of research in the form descriptive explanatory and verificative and also uses questioner as premier data to get the describing in conditions. The analysis tool in this research used path analysis. The test results of this research show and found a positive and significant effect between rotation and competency to motivation either partially or simultaneously. The implications of these findings is the realization of one attempt and have a good rotation appropriate to competency so as to improve employee motivation. Keywords : Rotation, Competency and Motivation
Abstract
Europe PMC (https://europepmc.org) is a database of research articles, including peer reviewed full text articles and abstracts, and preprints - all freely available for use via website, ...APIs and bulk download. This article outlines new developments since 2017 where work has focussed on three key areas: (i) Europe PMC has added to its core content to include life science preprint abstracts and a special collection of full text of COVID-19-related preprints. Europe PMC is unique as an aggregator of biomedical preprints alongside peer-reviewed articles, with over 180 000 preprints available to search. (ii) Europe PMC has significantly expanded its links to content related to the publications, such as links to Unpaywall, providing wider access to full text, preprint peer-review platforms, all major curated data resources in the life sciences, and experimental protocols. The redesigned Europe PMC website features the PubMed abstract and corresponding PMC full text merged into one article page; there is more evident and user-friendly navigation within articles and to related content, plus a figure browse feature. (iii) The expanded annotations platform offers ∼1.3 billion text mined biological terms and concepts sourced from 10 providers and over 40 global data resources.
Ciz1 promotes initiation of mammalian DNA replication and is present within nuclear matrix associated DNA replication factories. Depletion of Ciz1 from normal and cancer cells restrains entry to S ...phase and inhibits cell proliferation. Several alternative splicing events with putative functional consequences have been identified and reported, but many more variants are predicted to exist based on publicly available mRNAs and expressed sequence tags.
Here we report the development and validation of a custom exon and exon-junction microarray focused on the human CIZ1 gene, capable of reproducible detection of differential splice-variant expression.
Using a pair of paediatric cancer cell lines and a pool of eight normal lines as reference, the array identified expected and novel CIZ1 splicing events. One novel variant (delta 8-12) that encodes a predicted protein lacking key functional sites, was validated by quantitative RT-PCR and found to be over-represented in a range of other cancer cell lines, and over half of a panel of primary lung tumours.
Expression of CIZ1 delta 8-12 appears to be restricted to cancer cells, and may therefore be a useful novel biomarker.
Few epidemiologic cohort studies have evaluated atrial flutter (flutter) as an arrhythmia distinct from atrial fibrillation (AF).
The purpose of this study was to examine the clinical correlates of ...flutter and its associated outcomes to distinguish them from those associated with AF in the Framingham Heart Study.
We reviewed and adjudicated electrocardiograms (ECGs) previously classified as flutter or AF/flutter and another 100 ECGs randomly selected from AF cases. We examined the clinical correlates of flutter by matching up to 5 AF and 5 referents to each flutter case using a nested case referent design. We determined the 10-year outcomes associated with flutter with Cox models.
During mean follow-up of 33.0 ± 12.2 years, 112 participants (mean age 72 ± 10 years, 30% women) developed flutter. In multivariable analyses, smoking (odds ratio OR 2.84, 95% confidence interval CI 1.54-5.23), increased PR interval (OR 1.28 per SD, 95% CI 1.03-1.60), myocardial infarction (OR 2.25, 95% CI 1.05-4.80) and heart failure (OR 5.22, 95% CI 1.26-21.64) were associated with incident flutter. In age- and sex-adjusted models, flutter (vs referents) was associated with 10-year increased risk of AF (hazard ratio HR 5.01, 95% CI 3.14-7.99), myocardial infarction (HR 3.05, 95% CI 1.42-6.59), heart failure (HR 4.14, 95% CI 1.90-8.99), stroke (HR 2.17, 95% CI 1.13-4.17), and mortality (HR 2.00, 95% CI 1.44-2.79).
We identified the clinical correlates associated with flutter and observed that flutter was associated with multiple adverse outcomes.
Aim/Purpose: This study aims to analyze (1) the effect of organizational support on Technological Pedagogical Content Knowledge (TPACK), (2) the effect of organizational support and TPACK on teacher ...performance, (3) the effect of organizational support and TPACK on technostress, and (4) the effect of technostress on teacher performance. Background: The disruption of Information Technology (IT) innovation in educational practice happened two decades ago. However, the more massive and intense IT integration in teaching and learning practice was demanded during the COVID-19 pandemic. These circumstances made teachers and students face a new teaching and learning environment with complete IT mediation. Therefore, they will show a unique response valuable for managing effective education and further research regarding teaching and learning in the online environment. Methodology: Using a purposive sampling technique, data was collected from 419 pre-service teachers in the economics and business field. The data was then tabulated and analyzed using PLS-SEM. Contribution: This study connects the concept of TPACK as knowledge to organizational support and technostress as the organizational and personal response to deal with massive IT integration in fully online learning during the COVID-19 pandemic. This study bridges the educational concept of teacher competence to the behavioral framework of IS users to deal with the online environment. Teaching and learning are tasks that engage human-to-human interaction, which is different from other productive activities like the business sector. Therefore, this study may give fruitful findings, both theoretically and practically, to improve educational practice in this digital age. Findings: Researchers found that organizational support and TPACK were valuable antecedents of teacher performance in an online environment. At the same time, technostress is not a critical threat to teacher performance. However, technostress exists among teachers and is uncontrollable by TPACK and organizational support. Researchers argue it is an unavoidable circumstance. The educational system demands a rapid shift to fully online learning due to the COVID-19 pandemic. Therefore, the teacher should accept the challenge to maintain the continuity of teaching and learning activities. Recommendations for Practitioners: (1) Teachers' knowledge and organizational support should become an essential concern for policy makers and school leaders to maintain teacher performance in this dynamic online environment. (2) The educational leader should develop a strategy to manage technostress among teachers from another aspect beyond TPACK and organizational support. (3) Policymakers should develop a strategy to compensate for teacher effort and sacrifices resulting from IT disruption in their working experience. Recommendation for Researchers: Researchers should confirm and refine the framework developed in the private sector to the educational sector to generate more theoretical and empirical understanding regarding the functional integration of IT devices on certain entities' productive tasks. Impact on Society: This study gives more understanding of how teachers respond to IT-integrated tasks in their academic activity. This discussion will give more wisdom to understand the threshold of IT usefulness in the educational field besides giving preference to managing it to maintain teachers' work quality. Future Research: Further research is required to identify the critical factors to manage teachers' technostress effectively. A qualitative research method may be helpful in exploring teachers' complex responses regarding IT-integrated tasks.
The associations of long-term patterns of risk factors and the risk of incident atrial fibrillation (AF) are incompletely characterized. Among 4351 Framingham Study participants (mean age 50±11 years ...at baseline examination, 57% women) from the original and offspring cohorts, we defined longitudinal patterns, referred to as trajectories, of AF risk factors and a composite AF risk score using ≈16 years of data. We used Cox proportional hazards models to examine the association of trajectories to 15-year risk of AF. During follow-up, 719 participants developed AF. Five distinct trajectory groups were identified for systolic blood pressure (BP): groups 1 and 2 (normotensive throughout), group 3 (prehypertensive), group 4 (hypertensive initially with decreasing BP), and group 5 (hypertensive and increasing BP). In multivariable-adjusted analyses, compared with group 1, groups 4 (hazard ratio 2.05; 95% confidence interval 1.24-3.37) and 5 (hazard ratio 1.95; 95% confidence interval 1.08-3.49) were associated with incident AF. Three trajectory groups were identified for antihypertensive treatment. Compared with the group with no treatment throughout, the other 2 groups were associated with increased risk of incident AF. Distinct trajectories for diastolic BP, smoking, diabetes mellitus, and the composite risk score were not associated with increased 15-year risk of AF. Longitudinal trajectories may distinguish how exposures related to AF contribute toward prospective AF risk. Distinct trajectory groups with persistently elevated systolic BP and longer antihypertensive treatment are associated with increased risk of incident AF.
Secara umum kinerja karyawan memiliki beberapa faktor pendukung agar mendapatkan hasil maksimal. Pengaruh dari lingkungan kerja dan budaya kerja Islam dalam Perusahaan di lembaga keuangan asuransi ...jiwa menggunakan prinsip Islam dalam menjalankan kegiatan bisnis dan operasionalnya berpengaruh pada kinerja pegawai/karyawan. Tentunya dengan adanya hasil penelitian sesuai dengan judul diatas sudah seharusnya usaha faktor lingkungan kerja maupun budaya kerja islam dapat ditingkatkan sehingga kinerja karyawan menjadi lebih baik lagi. Hasil penelitian ini bertujuan untuk mendapatkan penjelasan dan mendeskripsikan apakah variable X1 yaitu lingkungan kerja serta variable X2 yaitu budaya kerja Islam terdapat pengaruh bagi kinerja karyawan. Selanjutnya, penulis menggunakan metode kuantitatif dengan mendeskripsikan hasil penelitian dengan responden merupakan karyawan Perusahaan yang telah mengisi dan melengkapi dokumen kuesioner penelitian yang telah ditetapkan sebelumnya sebagai instrumen penelitian. Peneliti juga menggunakan aplikasi software SPSS sebagai alat bantu perhitungan statitstik dari data yang telah dikumpulkan untuk mendukung dan mengolah data penelitian. Peneliti melakukan penelitian yang telah dijalankan bahwa hasil pengujian hipotesis antara variable lingkungan kerja sebagai X1, variable budaya kerja Islam sebagai X2 serta Variabel kinerja karyawan sebagai Y. Penelitian dilakukan untuk menunjukan apakah lingkungan kerja sebagai variable X1 berpengaruh terhadap variable Y yaitu kinerja karyawan, budaya kerja Islam sebagai variable X2 terhadap kinerja karyawan sebagai variabel Y serta Variabel X1 dan X2 masing-masing yaitu lingkungan kerja serta budaya kerja Islam berpengaruh pada variabel Y yang ditentukan sebagai kinerja karyawan secara bersamaan. Dalam penelitian ini disimpulkan (1) variabel X1 yang ditentukan sebagia lingkungan kerja mempunyai pengaruh positif signifikan kepada varibel Y (2) variable X2 yaitu budaya kerja Islam mempunyai pengaruh positif signifikan kepada variable Y, terakhir (3) variabel X1 sebagai lingkungan kerja serta budaya kerja Islam sebagai variable X2 secara bersamaan memiliki pengaruh yang positif signifikan kepada variabel Y.
Delonix regia (Bojer ex Hook.) Raf., Cassia fistula L. and Lagerstroemia speciosa L. are three ornamental plants that produce colorful flowers. The present study aimed to evaluate the phytochemicals ...and bioactivities of methanolic extracts of flowers from Delonix regia (DrFME), Cassia fistula (CfFME), and Lagerstroemia speciosa (LsFME). The presence of ten different chemical classes in varying degrees was confirmed while qualitatively screened. During quantitative determination, LsFME possesses the highest amount of total phenolic (418.0 mg/g), flavonoid (50.8 mg/g), and tannin (256.3 mg/g) contents. The extracts showed excellent antioxidant capacity in a concentration-dependent manner with the lowest IC50 value (41.51 μg/mL) displayed by LsFME. LsFME paralyzed the experimental worms at 2.95 min and killed at 3.96 min. DrFME was found to be more effective in thrombolytic (35.5% clot lysis) and anticoagulant activities. Negligible hemolytic activity (IC50 > 200 μg/mL) found for all extracts which suggest their less potential toxicity. The in vivo experiments revealed that the CfFME has the highest analgesic (64.34% pain inhibition) activity while LsFME has the highest antidiarrheal (70.27% inhibition) and antihyperglycemic (46.94% inhibition) activities at 400 mg/kg of body weight doses. This study has shown the presence of phytochemicals and potential bioactivities which indicates the possibility of these flowers to be used as a source of phytochemicals as well as safe and effective natural medicine.
•Krisnachura (Delonix regia), Sonalu (Cassia fistula), and Jarul (Lagerstroemia speciosa) are colorful flower producing ornamental plants grown in Bangladesh.•The flowers of these plants are rich in phytochemicals and exhibit antioxidant, anthelmintic, thrombolytic, anticoagulant, analgesic, antidiarrheal and antihyperglycemic activities as determined by in vitro and in vivo methods.•The flowers can be used as a source of safe and effective natural medicine.
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