Roughly 3% of the Earth's land surface burns annually, representing a critical exchange of energy and matter between the land and atmosphere via combustion. Fires range from slow smouldering peat ...fires, to low-intensity surface fires, to intense crown fires, depending on vegetation structure, fuel moisture, prevailing climate, and weather conditions. While the links between biogeochemistry, climate and fire are widely studied within Earth system science, these relationships are also mediated by fuels-namely plants and their litter-that are the product of evolutionary and ecological processes. Fire is a powerful selective force and, over their evolutionary history, plants have evolved traits that both tolerate and promote fire numerous times and across diverse clades. Here we outline a conceptual framework of how plant traits determine the flammability of ecosystems and interact with climate and weather to influence fire regimes. We explore how these evolutionary and ecological processes scale to impact biogeochemical and Earth system processes. Finally, we outline several research challenges that, when resolved, will improve our understanding of the role of plant evolution in mediating the fire feedbacks driving Earth system processes. Understanding current patterns of fire and vegetation, as well as patterns of fire over geological time, requires research that incorporates evolutionary biology, ecology, biogeography, and the biogeosciences.
Abstract
Natural variability in menstrual cycle length, coupled with rapid changes in endometrial gene expression, makes it difficult to accurately define and compare different stages of the ...endometrial cycle. Here we develop and validate a method for precisely determining endometrial cycle stage based on global gene expression. Our ‘molecular staging model’ reveals significant and remarkably synchronised daily changes in expression for over 3400 endometrial genes throughout the cycle, with the most dramatic changes occurring during the secretory phase. Our study significantly extends existing data on the endometrial transcriptome, and for the first time enables identification of differentially expressed endometrial genes with increasing age and different ethnicities. It also allows reinterpretation of all endometrial RNA-seq and array data that has been published to date. Our molecular staging model will significantly advance understanding of endometrial-related disorders that affect nearly all women at some stage of their lives, such as heavy menstrual bleeding, endometriosis, adenomyosis, and recurrent implantation failure.
Westward winds have now been inferred for two hot Jupiters (HJs): HAT-P-7b and CoRoT-2b. Such observations could be the result of a number of physical phenomena such as cloud asymmetries, ...asynchronous rotation, or magnetic fields. For the hotter HJs magnetic fields are an obvious candidate, though the actual mechanism remains poorly understood. Here we show that a strong toroidal magnetic field causes the planetary-scale equatorial magneto-Kelvin wave to structurally shear as it travels, resulting in westward tilting eddies, which drive a reversal of the equatorial winds from their eastward hydrodynamic counterparts. Using our simplified model we estimate that the equatorial winds of HAT-P-7b would reverse for a planetary dipole field strength , a result that is consistent with three-dimensional magnetohydrodynamic simulations and lies below typical surface dipole estimates of inflated HJs. The same analysis suggests the minimum dipole field strength required to reverse the winds of CoRoT-2b is , which considerably exceeds estimates of the maximum surface dipole strength for HJs. We hence conclude that our magnetic wave-driven mechanism provides an explanation for wind reversals on HAT-P-7b; however, other physical phenomena provide more plausible explanations for wind reversals on CoRoT-2b.
Abstract
Magnetically driven hotspot variations (which are tied to atmospheric wind variations) in hot Jupiters are studied using nonlinear numerical simulations of a shallow-water ...magnetohydrodynamic (SWMHD) system and a linear analysis of equatorial SWMHD waves. In hydrodynamic models, mid-to-high-latitude geostrophic circulations are known to cause a net west-to-east equatorial thermal energy transfer, which drives hotspot offsets eastward. We find that a strong toroidal magnetic field can obstruct these energy transporting circulations. This results in winds aligning with the magnetic field and generates westward Lorentz force accelerations in hotspot regions, ultimately causing westward hotspot offsets. In the subsequent linear analysis we find that this reversal mechanism has an equatorial wave analogy in terms of the planetary-scale equatorial magneto-Rossby waves. We compare our findings to three-dimensional MHD simulations, both quantitatively and qualitatively, identifying the link between the mechanics of magnetically driven hotspot and wind reversals. We use the developed theory to identify physically motivated reversal criteria, which can be used to place constraints on the magnetic fields of ultra-hot Jupiters with observed westward hotspots.
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•ZIF-4, -7, -8, -14 and -67 electrode coatings obtained via anodic dissolution.•Reaction conditions optimised to favour coating formation.•Capacitance of 10.45mFcm−2 for ZIF-67, ...highest for additive free MOF.
Zn and Co electrodes have been successfully coated with five different zeolitic imidazolate frameworks ZIFs (ZIF-4, ZIF-7, ZIF-8, ZIF-14 and ZIF-67) via the anodic dissolution method. Careful control of the reaction conditions allows for electrode coating growth; in contrast to previous reports of electrochemical ZIF growth, which have not succeeded in obtaining ZIF electrode coatings. Coating crystallinity is also shown to be heavily dependent upon reaction conditions, with amorphous rather than crystalline material generated at shorter reaction times and lower linker concentrations. Electrochemical applications for ZIF-coated electrodes are highlighted with the observation of an areal capacitance of 10.45 mF cm−2 at 0.01Vs−1 for additive-free ZIF-67 coated Co electrodes. This is superior to many reported metal organic framework (MOF)/graphene composites and to capacitance values previously reported for additive-free MOFs.
Abstract
Study question
Are uterine natural killer (uNK) cell numbers and their distribution relative to endometrial arterioles altered in women with recurrent implantation failure (RIF) compared to ...women with embryo implantation success (IS)?
Summary answer
uNK cell numbers and their distribution relative to endometrial arterioles are not significantly different in women with RIF compared to women in whom embryo implantation occurs successfully following IVF.
What is already known
uNK cells are regulators of decidual angiogenesis and spiral arteriole remodelling during early pregnancy. Although some studies have shown that uNK cell numbers may be altered in women with RIF, the methods used to measure uNK cell numbers have proven inconsistent, making reproduction of these results difficult. It is unclear, therefore, whether the results reported so far are reproducible. Moreover, it is not known how uNK cell numbers may impact IVF outcomes. Despite the lack of conclusive evidence, uNK cell numbers are often evaluated as a prognostic criterion in women undergoing assisted reproductive procedures.
Study design, size, duration
Endometrial pipelle biopsies were collected 6–8 days post-LH surge in natural cycles from women with RIF (n = 14), women with IS (n = 11) and women with potential RIF at the time of the study (PRIF; n = 9) from 2013 to 2015.
Participants/materials, setting, methods
uNK cells (i.e. CD56+ and/or CD16+ phenotypes) and their distribution relative to endometrial arterioles were investigated by standard immunohistochemistry protocols and quantified using Aperio ScanScopeXT images digitized by ImageJ and deconvoluted into binary images for single cell quantification using a Gaussian Blur and Yen algorithm.
Main results and the role of chance
There was no significant difference in the cell density of CD56+ or CD16+ uNK cells in women with RIF compared to women with IS or PRIF. There was a higher proportion of uNK cells in the distal regions compared to the regions closest to the arterioles in all patient groups. Further, we identified a significant reduction in uNK cell density in women who had a previous pregnancy compared to those who had not, regardless of their current implantation status.
Large scale data
Not applicable.
Limitations, reasons for caution
Spiral arterioles could not always be accurately identified by digital image analysis; therefore, all endometrial arterioles were selected and analysed. Patient numbers for the study were low. However, as the clinical phenotypes of each patient were well defined, and endometrial dating was accurately determined by three independent pathologists, differences between patient groups with respect to the uNK numbers and distribution should have been measurable if uNK cell counts were to be useful as a prognostic marker of RIF.
Wider implications of the findings
Our findings demonstrate that CD56+ and CD16+ uNK cell numbers are not significantly different in women with RIF in a typical cohort of women undergoing IVF. Further, prior pregnancy was associated with a significantly reduced number of uNK cells in both the RIF and IS patient groups, suggestive of a long-term pregnancy induced suppression of uNK cells. Combined, these findings do not support the clinical value of using uNK cell numbers as a prognostic indicator of implantation success with IVF treatment.
Study funding/competing interest(s)
Funding for this work was provided by Royal Women’s Hospital Foundation. P.P. was supported by an NHMRC Early Career Fellowship TF 11/14 and W.T.T. was supported by an NHMRC Postgraduate Scholarship 1055814. The authors do not have any competing interests with this study.
Endometriosis is an estrogen-dependent disorder where endometrial tissue
forms lesions outside the uterus. Endometriosis affects an estimated 10% of women
in the reproductive-age group, rising to 30% ...to 50% in patients with infertility
and/or pain, with significant impact on their physical, mental, and social
well-being. There is no known cure, and most current medical treatments are not
suitable long term due to their side-effect profiles. Endometriosis has an
estimated annual cost in the United States of $18.8 to $22 billion (2002 figures).
Although endometriosis was first described more than 100 years ago, current
knowledge of its pathogenesis, spontaneous evolution, and the pathophysiology of
the related infertility and pelvic pain, remain unclear. A consensus workshop was
convened following the 10th World Congress on Endometriosis to establish
recommendations for priorities in endometriosis research. One major issue
identified as impacting on the capacity to undertake endometriosis research is the
need for multidisciplinary expertise. A total of 25 recommendations for research
have been developed, grouped under 5 subheadings: (1) diagnosis, (2)
classification and prognosis, (3) treatment and outcome, (4) epidemiology, and (5)
pathophysiology. Endometriosis research is underfunded relative to other diseases
with high health care burdens. This may be due to the practical difficulties of
developing competitive research proposals on a complex and poorly understood
disease, which affects only women. By producing this consensus international
research priorities statement it is the hope of the workshop participants that
researchers will be encouraged to develop new interdisciplinary research proposals
that will attract increased funding support for work on endometriosis.
Do menstrual cycle-dependent changes occur in the histological appearance of superficial peritoneal endometriotic lesions, and are they equivalent to those observed in the eutopic endometrium?
Only a ...small subset of superficial peritoneal endometriotic lesions exhibits some histological features in phase with menstrual cycle-related changes observed in eutopic endometrium.
Endometriotic lesions are frequently described as implants that follow menstrual cycle-related changes in morphology, as per the eutopic endometrium. This concept has been widely accepted despite the lack of conclusive published evidence.
This was a retrospective cohort study of 42 patients, from across the menstrual cycle, with surgically and histologically confirmed endometriosis. Patients were a subset selected from a larger endometriosis study being conducted at the Royal Women's Hospital, Melbourne since 2012.
Histological features of epithelium, stroma and gland morphology were examined in haematoxylin and eosin stained sections of superficial peritoneal endometriotic lesions and matched eutopic endometrium (menstrual: n = 4, proliferative: n = 11, secretory: n = 17, hormone-treated: n = 10). At least two biopsies (average = 4, range = 2-8 biopsies) and a matched endometrial sample were analysed for each patient and results were presented per endometriotic gland profile (n = 1051). Data were analysed using mixed effects logistic regression to account for multiple patients and multiple endometriotic biopsies, each with multiple endometriotic gland profiles. This model also enabled analysis of endometriotic lesions versus eutopic endometrium.
There was considerable inter- and intra-patient variability in the morphology of superficial peritoneal endometriotic lesions. Menstrual cycle-associated changes were only observed for some features in a subset of endometriotic gland profiles. The proportion of endometriotic gland profiles with epithelial mitoses significantly increased in the proliferative phase (18% of gland profiles) relative to the menstrual phase (0% of endometriotic gland profiles) (odds ratios (OR) 9.30; 95% confidence intervals (CI) = 3.71-23.32; P < 0.001). Fewer blood-filled gland lumens were observed in the secretory phase (45% of endometriotic gland profiles) compared to the menstrual phase (67% of endometriotic gland profiles) (OR, 0.30; 95% CI = 0.11-0.79; P = 0.015). The features of the eutopic endometrium analysed in this study did not reflect the results in matched endometriotic lesions (P > 0.05).
Not applicable.
This study focused on features observed in sections of superficial peritoneal lesions and these may differ from features of deep infiltrating endometriosis or ovarian endometriomas. Cycle phases were limited to menstrual, proliferative and secretory phases to allow appropriate statistical modelling.
This study highlights heterogeneity in the histological characteristics of superficial peritoneal lesions. It challenges the assumption that lesion morphology consistently reflects menstrual cycle-associated changes.
Research reported in this publication was supported in part by National Health and Medical Research Council (NHMRC) project grants GNT1012245, GNT1105321 and GNT1026033 (P.A.W.R., J.E.G. and S.J.H.-C.). There are no competing interests.
ABSTRACT
We report on the discovery and validation of TOI 813 b (TIC 55525572 b), a transiting exoplanet identified by citizen scientists in data from NASA’s Transiting Exoplanet Survey Satellite ...(TESS) and the first planet discovered by the Planet Hunters TESS project. The host star is a bright (V = 10.3 mag) subgiant ($R_\star =1.94\, R_\odot$, $M_\star =1.32\, M_\odot$). It was observed almost continuously by TESS during its first year of operations, during which time four individual transit events were detected. The candidate passed all the standard light curve-based vetting checks, and ground-based follow-up spectroscopy and speckle imaging enabled us to place an upper limit of $2\, M_{\rm Jup}$ (99 per cent confidence) on the mass of the companion, and to statistically validate its planetary nature. Detailed modelling of the transits yields a period of $83.8911 _{ - 0.0031 } ^ { + 0.0027 }$ d, a planet radius of 6.71 ± 0.38 R⊕ and a semimajor axis of $0.423 _{ - 0.037 } ^ { + 0.031 }$ AU. The planet’s orbital period combined with the evolved nature of the host star places this object in a relatively underexplored region of parameter space. We estimate that TOI 813 b induces a reflex motion in its host star with a semi-amplitude of ∼6 m s−1, making this a promising system to measure the mass of a relatively long-period transiting planet.
Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European ...and East Asian descent, identified 42 genome-wide significant loci comprising 49 distinct association signals. Effect sizes were largest for stage 3/4 disease, driven by ovarian endometriosis. Identified signals explained up to 5.01% of disease variance and regulated expression or methylation of genes in endometrium and blood, many of which were associated with pain perception/maintenance (SRP14/BMF, GDAP1, MLLT10, BSN and NGF). We observed significant genetic correlations between endometriosis and 11 pain conditions, including migraine, back and multisite chronic pain (MCP), as well as inflammatory conditions, including asthma and osteoarthritis. Multitrait genetic analyses identified substantial sharing of variants associated with endometriosis and MCP/migraine. Targeted investigations of genetically regulated mechanisms shared between endometriosis and other pain conditions are needed to aid the development of new treatments and facilitate early symptomatic intervention.