The cyclic adenosine monophosphate–dependent protein kinase A (PKA) pathway helps regulate both cell growth and division, and triglyceride storage and metabolism in response to nutrient status. ...Studies in yeast show that disruption of this pathway promotes longevity in a manner similar to caloric restriction. Because PKA is highly conserved, it can be studied in mammalian systems. This report describes the metabolic phenotype of mice lacking the PKA catalytic subunit Cβ. We confirmed that Cβ has high levels of expression in the brain but also showed moderate levels in liver. Cβ-null animals had reduced basal PKA activity while appearing overtly normal when fed standard rodent chow. However, the absence of Cβ protected mice from diet-induced obesity, steatosis, dyslipoproteinemia, and insulin resistance, without any differences in caloric intake or locomotor activity. These findings have relevant pharmacological implications because aging in mammals is characterized by metabolic decline associated with obesity, altered body fat distribution, and insulin resistance.
Uncertainties in global change impacts, the complexities associated with the interconnected cycling of nitrogen, carbon, and water present daunting management challenges. Existing models provide ...detailed information on specific sub-systems (e.g., land, air, water, and economics). An increasing awareness of the unintended consequences of management decisions resulting from interconnectedness of these sub-systems, however, necessitates coupled regional earth system models (EaSMs). Decision makers’ needs and priorities can be integrated into the model design and development processes to enhance decision-making relevance and “usability” of EaSMs. BioEarth is a research initiative currently under development with a focus on the U.S. Pacific Northwest region that explores the coupling of multiple stand-alone EaSMs to generate usable information for resource decision-making. Direct engagement between model developers and non-academic stakeholders involved in resource and environmental management decisions throughout the model development process is a critical component of this effort. BioEarth utilizes a bottom-up approach for its land surface model that preserves fine spatial-scale sensitivities and lateral hydrologic connectivity, which makes it unique among many regional EaSMs. Here, we describe the BioEarth initiative and highlights opportunities and challenges associated with coupling multiple stand-alone models to generate usable information for agricultural and natural resource decision-making.
Take Note Kilpatrick, Lorrell D.; Ruby, Brian K.
Contemporary Sociology,
03/2004, Volume:
33, Issue:
2
Journal Article, Book Review
Peer reviewed
Several books on sociology are reviewed. These include Sexuality and Society: An Introduction by Gargi Bhattacharyya; Social Class, Politics, and Urban Markets: The Makings of Bias in Policy Outcomes ...by Herman L. Boschken; and Masculinities Matter: Men, Gender, and Development edited by Frances Cleaver.
Take Note Kilpatrick, Lorrell D.; Ruby, Brian K.
Contemporary Sociology,
05/2003, Volume:
32, Issue:
3
Journal Article, Book Review
Peer reviewed
Several books on sociology including "Communism and the Remorse of an Innocent Victimizer" by Zlatko Anguelov, "Leviathan Transformed: Seven National States in the New Century" edited by Theodore ...Caplow, and "The Shabbat Elevator and Other Sabbath Subterfuges: An Unorthodox Essay on Circumventing Custom and Jewish Character" by Alan Dundes are reviewed.
The cyclic adenosine monophosphate - dependent protein kinase A (PKA) pathway helps regulate both cell growth and division, and triglyceride storage and metabolism in response to nutrient status. ...Studies in yeast show that disruption of this pathway promotes longevity in a manner similar to caloric restriction. Because PKA is highly conserved, it can be studied in mammalian systems. This report describes the metabolic phenotype of mice lacking the PKA catalytic subunit Cβ. We confirmed that Cβ has high levels of expression in the brain but also showed moderate levels in liver. Cβ-null animals had reduced basal PKA activity while appearing overtly normal when fed standard rodent chow. However, the absence of Cβ protected mice from diet-induced obesity, steatosis, dyslipoproteinemia, and insulin resistance, without any differences in caloric intake or locomotor activity. These findings have relevant pharmacological implications because aging in mammals is characterized by metabolic decline associated with obesity, altered body fat distribution, and insulin resistance. PUBLICATION ABSTRACT
Take Note Krebs, Thomas J.; Ruby, Brian K.; Swygart, Amanda J.
Contemporary Sociology,
05/2001, Volume:
30, Issue:
3
Journal Article, Book Review
Peer reviewed
Several books, including "In the Web of Politics: Three Decades of the U.S. Federal Executive" by Joel D. Aberbach and Bert A. Rockman and "'Law Never Here': A Social History of African American ...Responses to Issues of Crime and Justice" by Frankie Y. Bailey and Alice P. Green, are reviewed.
Take Note Kilpatrick, Lorrell D.; Ruby, Brian K.
Contemporary Sociology,
01/2004, Volume:
33, Issue:
1
Journal Article, Book Review
Peer reviewed
Several sociology books are reviewed, including Redesigning Society by Russell L. Ackoff and Sheldon Rovin, Lost Geographies of Power by John Allen, and The Information Economy and American Cities by ...Matthew P. Drennan.
Take Note Kilpatrick, Lorrell D; Ruby, Brian K
Contemporary Sociology,
09/2003, Volume:
32, Issue:
5
Journal Article, Book Review
Peer reviewed
Several books on sociology are reviewed, including "Race in Mind: Race, IQ, and Other Racisms" by Alexander Alland Jr, "Gender Roles at Home and Abroad: The Adaptation of Bangladeshi Immigrants" by ...Kaari Flagstad Baluja, and "Not the Triumph but the Struggle: The 1968 Olympics and the Making of the Black Athlete" by Amy Bass.
Take Note Kilpatrick, Lorrell D; Ruby, Brian K
Contemporary Sociology,
07/2003, Volume:
32, Issue:
4
Journal Article, Book Review
Peer reviewed
Several books on contemporary sociology are reviewed. These include "Building a People's University in South Africa: Race, Compensatory Education, and the Limits of Democratic Reform" by Gregory M. ...Anderson; "Sex and Sexuality Among New York's Puerto Rican Youth" by Marysol Asencio; "State/Space: A Reader" edited by Neil Brenner, Bob Jessop, Martin Jones, and Gordon MacLeod; and "The Mirth of Nations" by Christie Davies.
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