S100 proteins are demonstrated to exert a protective role in the gastrointestinal tract. In the present study, we investigated whether S100B protein, that is typically expressed by enteroglial cells, ...is detectable in feces and could be a useful noninvasive indicator of gut chronic inflammation.
This clinical prospective study included n=48 patients suffering Crohn's disease (CD) or ulcerative colitis (UC) and non IBD-controls. The clinical disease activity was evaluated using Harvey-Bradshaw or Mayo Score Index while the diagnosis of IBD was defined based on standard endoscopic and histological criteria. S100B and calprotectin were extracted and analyzed using commercial enzyme-linked immunosorbent assay (ELISA) kits.
Unlike calprotectin, S100B was significantly decreased in both CD and UC compared to non IBD-patients. The strongest quantitative alterations of S100B were detected concomitantly with signs of active or quiescent disease, including high/normal expression of fecal calprotectin, mucosal damage/cryptitis, mucin depletion and inflammatory infiltrate, as defined by endoscopic evaluation and histological analysis. At the onset of disease and under no Infliximab-based therapy, the lowest was detected suggesting that S100B in feces could have a potential diagnostic value for IBD.
Testing for S100B and calprotectin could be a useful screening tool to better predict IBD activity.
Muon identification in the Belle experiment at KEKB Abashian, A; Abe, K; Abe, K ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
09/2002, Volume:
491, Issue:
1-2
Journal Article
Peer reviewed
Open access
This paper describes the muon identification method and its performance in the Belle experiment at KEKB. Muon and hadron likelihood are calculated for each track using its range and transverse ...scattering in the KL-and-muon detector (KLM). We apply a cut on the normalized muon likelihood Lμ to identify the track as a muon. Above the detection threshold of 0.6GeV/c, the measured muon detection efficiency and pion fake rate are approximately constant for momenta greater than 1.0 and 1.5GeV/c, respectively. Between 1.0 and 3.0GeV/c, the averaged muon detection efficiency is 89% and the pion fake rate per track is 1.4% over the KLM acceptance, using the standard selection criterion Lμ>0.9.
We report recent measurements of the three angles of the unitarity triangle using the data collected with the BABAR detector at the PEP-II asymmetric energy
e
+
e
-
collider.
This paper reports measurements of final-state proton multiplicity, muon and proton kinematics, and their correlations in charged-current pionless neutrino interactions, measured by the T2K ND280 ...near detector in its plastic scintillator (C8H8) target. The data were taken between years 2010 and 2013, corresponding to approximately 6×1020 protons on target. Thanks to their exploration of the proton kinematics and of imbalances between the proton and muon kinematics, the results offer a novel probe of the nuclear-medium effects most pertinent to the (sub-)GeV neutrino-nucleus interactions that are used in accelerator-based long-baseline neutrino oscillation measurements. These results are compared to many neutrino-nucleus interaction models which all fail to describe at least part of the observed phase space. In case of events without a proton above a detection threshold in the final state, a fully consistent implementation of the local Fermi gas model with multinucleon interactions gives the best description of the data. In the case of at least one proton in the final state, the spectral function model agrees well with the data, most notably when measuring the kinematic imbalance between the muon and the proton in the plane transverse to the incoming neutrino. Within the models considered, only the existence of multinucleon interactions are able to describe the extracted cross section within regions of high transverse kinematic imbalance. The effect of final-state interactions is also discussed.
This paper reports the first simultaneous measurement of the double differential muon neutrino charged-current cross section on oxygen and carbon without pions in the final state as a function of the ...outgoing muon kinematics, made at the ND280 off-axis near detector of the T2K experiment. The ratio of the oxygen and carbon cross sections is also provided to help validate various models' ability to extrapolate between carbon and oxygen nuclear targets, as is required in T2K oscillation analyses. The data are taken using a neutrino beam with an energy spectrum peaked at 0.6 GeV. The extracted measurement is compared with the prediction from different Monte Carlo neutrino-nucleus interaction event generators, showing particular model separation for very forward-going muons. Overall, of the models tested, the result is best described using local Fermi gas descriptions of the nuclear ground state with RPA suppression.
This paper presents the first combined measurement of the double-differential muon neutrino and antineutrino charged-current cross sections with no pions in the final state on hydrocarbon at the ...off-axis near detector of the T2K experiment. The data analyzed in this work comprise 5.8 × 10 20 and 6.3 × 10 20 protons on target in neutrino and antineutrino mode respectively, at a beam energy peak of 0.6 GeV. Using the two measured cross sections, the sum, difference, and asymmetry were calculated with the aim of better understanding the nuclear effects involved in such interactions. The extracted measurements have been compared with the prediction from different Monte Carlo generators and theoretical models showing that the difference between the two cross sections have interesting sensitivity to nuclear effects.
A
bstract
The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The ...electron neutrino scattering is measured directly with the T2K off-axis near detector, ND280. The selection of the electron (anti-)neutrino events in the plastic scintillator target from both neutrino and anti-neutrino mode beams is discussed in this paper. The flux integrated single differential charged-current inclusive electron (anti-)neutrino cross-sections,
dσ/dp
and
dσ/d
cos(
θ
), and the total cross-sections in a limited phase-space in momentum and scattering angle (
p >
300 MeV/c and
θ ≤
45°) are measured using a binned maximum likelihood fit and compared to the neutrino Monte Carlo generator predictions, resulting in good agreement.
The second phase of the T2K experiment is expected to start data taking in autumn 2022. An upgrade of the Near Detector (ND280) is under development and includes the construction of two new Time ...Projection Chambers called High-Angle TPC (HA-TPC). The two endplates of these TPCs will be paved with eight Micromegas type charge readout modules. The Micromegas detector charge amplification structure uses a resistive anode to spread the charges over several pads to improve the space point resolution. This innovative technique is combined with the bulk-Micromegas technology to compose the “Encapsulated Resistive Anode Micromegas” detector. A prototype has been designed, built and exposed to an electron beam at the DESY II test beam facility.
The data have been used to characterize the charge spreading and to produce its map. Spatial resolution better than 600 μm and energy resolution better than 9% are obtained for all incident angles. These performances fulfil the requirements for the upgrade of the ND280 TPC.
Muon neutrino and antineutrino disappearance probabilities are identical in the standard three-flavor neutrino oscillation framework, but CPT violation and nonstandard interactions can violate this ...symmetry. In this work we report the measurements of sin2θ23 and Δ$m$$^{2}_{32}$ independently for neutrinos and antineutrinos. The aforementioned symmetry violation would manifest as an inconsistency in the neutrino and antineutrino oscillation parameters. The analysis discussed here uses a total of 1.97 × 1021 and 1.63 × 1021 protons on target taken with a neutrino and antineutrino beam respectively, and benefits from improved flux and cross section models, new near-detector samples and more than double the data reducing the overall uncertainty of the result. No significant deviation is observed, consistent with the standard neutrino oscillation picture.
This paper reports the first measurement of muon neutrino charged-current interactions without pions in the final state using multiple detectors with correlated energy spectra at T2K. The data was ...collected on hydrocarbon targets using the off-axis T2K near detector (ND280) and the on-axis T2K near detector (INGRID) with neutrino energy spectra peaked at 0.6 GeV and 1.1 GeV respectively. The correlated neutrino flux presents an opportunity to reduce the impact of the flux uncertainty and to study the energy dependence of neutrino interactions. The extracted double-differential cross sections are compared to several Monte Carlo neutrino-nucleus interaction event generators showing the agreement between both detectors individually and with the correlated result.
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