The aim of this prospective follow-up study is to describe the long-term outcome of obsessive-compulsive disorders (OCD) with onset in childhood or adolescence as well as psychiatric comorbidity.
A ...cohort of 30 former patients who had been treated for OCD in the Clinic for Child and Adolescent Psychiatry of the University of Würzburg were assessed by means of standardized measures in a personal examination at the beginning of their treatment and again after a follow-up period of 6 years.
At follow-up, 46.7% of the participants still fulfilled the DSM-IV criteria for OCD. Some 23.3% of the former patients showed subclinical OCD symptoms. 70% met the criteria for any Axis I disorder. Predominantly anxiety and affective disorders, but also obsessive-compulsive and anxious-avoidant personality disorders were found. Six persons showed a complete remission.
The rate of 46.7% persistent OCD matches the outcomes found in a meta-analysis (41%); however, lower persistence rates were expected in view of improved treatment options. An extension of the sample planned. FActors maintaining preservation of OCD should be analyzed,
Within the German Tropospheric Research Programme (TFS) numerous kinetic and mechanistic studies on the tropospheric reaction/degradation of the following reactants were carried out:* oxygenated VOC, ...* aromatic VOC, * biogenic VOC, *short-lived intermediates, such as alkoxy and alkylperoxy radicals.At the conception of the projects these selected groups were classes of VOC or intermediates for which the atmospheric oxidation mechanisms were either poorly characterised or totally unknown. The motivation for these studies was the attainment of significant improvements in our understanding of the atmospheric chemical oxidation processes of these compounds, particularly with respect to their involvement in photooxidant formation in the troposphere. In the present paper the types of experimental investigations performed and the results obtained within the various projects are briefly summarised. The major achievements are highlighted and discussed in terms of their contribution to improving our understanding of the chemical processes controlling photosmog formation in the troposphere.PUBLICATION ABSTRACT
This study contained herein assessed long-term results, toxicity, and prognostic variables following combined modality therapy of patients with International Union Against (Cancer Classification ...T1-4, N0-3, M0 squamous-cell carcinoma of the anal canal.
Between 1985 and 1996, 62 patients completed treatment with combined modality therapy. A median total dose of 50 Gy was given to the primary, perirectal, presacral, and inguinal nodes followed by a local boost in selected cases. 5-Fluorouracil was scheduled as a continuous infusion of 1,000 mg/m2 per 24 hours on days 1 to 5 and 29 to 33 and mitomycin C as a bolus of 10 mg/m2 on days 1 and 29. Routinely processed paraffin-embedded sections were stained using monoclonal antibodies for detection of proliferating cell nuclear antigen and MIB1 (Ki-67) antigen to determine the labeling index. In addition, DNA ploidy was assessed after Feulgen staining.
Actuarial cancer-related survival, no evidence of disease survival, and colostomy-free survival rates at five years were 81, 76, and 86 percent, respectively. In univariate analysis, T category (T1/2 vs. T3/4) was predictive for no evidence of disease survival (87 vs. 59 percent; P = 0.03) and colostomy-free survival (94 vs. 73 percent; P = 0.05). N category (N0 vs. N1-3) influenced actuarial cancer-related survival (85 vs. 58 percent; P = 0.002) and no evidence of disease survival (80 vs. 53 percent; P = 0.02). A higher proliferative potential as measured by the MIB1 labeling index was associated with a better colostomy-free survival (90 vs. 50 percent; P = 0.04). In multivariate analysis, actuarial cancer-related survival was only influenced by the N category (P = 0.03) and no evidence of disease survival by N category (P = 0.03) and mitomycin C dose (P = 0.04). Salvage abdominoperineal resection achieved long-term control in only four of seven patients with local failures.
Treatment with a combination of radiotherapy and chemotherapy is safe and effective for patients with anal canal carcinoma. Abdominoperineal resection is indicated as a salvage procedure in nonresponding and recurrent lesions and may be of benefit in a small subgroup of patients with poor prognostic factors.
Kunst im Zeitalter von Miced Media. Jetzt und für künftige Generationen - Zeitgenössische Kunst als DFG-gefördertes Sondersammelgebiet. Finden, was man sucht - Erschließung des Sondersammelgebietes. ...Schlagworte und Schlagwortketten - Schlüssel zu unsichtbaren Inhalten. Internetseiten- googles "best of". Schneller suchen - besser suchen.
Kunst im Zeitalter von Miced Media. Jetzt und für künftige Generationen - Zeitgenössische Kunst als DFG-gefördertes Sondersammelgebiet. Finden, was man sucht - Erschließung des Sondersammelgebietes. ...Schlagworte und Schlagwortketten - Schlüssel zu unsichtbaren Inhalten. Internetseiten- googles "best of". Schneller suchen - besser suchen.
Despite increased knowledge of nutrient intake regulation and energy homeostasis, treatment options for obesity remain limited. Food reward consists of two branches: gustatory and post-ingestive ...nutritive information. Drosophila lacking dSLC5A11 (sodium/glucose cotransporter 6-SGLT6) prefer L-glucose over D-glucose independently of their state of satiety. Human SGLT6 is an active transporter of myo-inositol and D-glucose. We investigated expression of SGLT6 in human tissue and found a significant expression in the small intestine and brain. The preference between a metabolizable and a non-metabolizable sugar was tested in 3 mouse models with a selective and potent SGLT6 inhibitor. No influence on sugar preference was seen with SGLT6 inhibition. These studies suggest that SGLT6 does not play a significant role in nutrient sensing in mammals.
Despite the unusually cold weather, numerous people gathered on 8 April 2008 for the ceremonial unveiling of the memorialSchlüssel gegen das Vergessen(Keys against forgetting), erected seventy years ...after the “Anschluss” in memory of the persecuted Jewish residents of the Servitengasse, a street in Vienna’s 9th district. Julia Schulz, an Austrian transmedia artist, designed the memorial: A glass case set into the ground, into which used keys have been placed, each bearing a nametag engraved with the name of a former resident or business owner from the street who was murdered or driven away under National Socialism. The keys
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