Purpose To evaluate by computerized tomography the long-term volume resorption of autogenous corticocancellous grafted bone harvested from the ilium and used in an alveolar augmentation procedure ...followed by endosseous dental implant placement. Patients and Methods Eleven maxillary grafts (8 positioned horizontally) and 13 mandibular grafts (10 positioned vertically) were placed in 16 patients. Using software programs, pre- and postsurgical computerized tomographic scans were used to compare volumes of grafts over time (up to 6 yr) to determine the annual percentage of remaining bone and the overall percentage of bone resorption that could be expected. Yearly measurements of volumes and percentages of remaining bone were then compared statistically. Results At the 6-year survey for blocks grafted in the mandible, an average resorption rate of 87% was obtained; for maxillary grafts at the same survey, complete resorption of the grafts (mean, 105.5%) was recorded. In general, bone resorption appeared slow, except for that recorded in the first 2 years of healing, the only period in which statistical comparisons among all time points showed significant differences for all variables. Conclusions Volumetric measurements of the grafts and their related percentages of remaining bone attested to a progressive and unavoidable bone resorption of almost all the grafted bone in the maxilla and mandible. Although the present data were from a heterogenous group of defects treated with horizontal and vertical procedures, clinicians, when performing alveolar bone augmentation with an autogenous hip bone, should aim at titanium dental implant osseointegration, not only in the augmented bone but also in the native bone below the graft.
Periodontitis has been associated with an increased risk of and mortality associated with human colorectal cancer (CRC). Current evidence attributes such an association to the direct and indirect ...effects of virulence factors belonging to periodontal pathogens, to inflammatory mediators and to genetic factors. The aims of the study were to assess the existence of a genetic linkage between periodontitis and human CRC, to identify genes considered predominant in such a linkage, thus named leader genes, and to determine pathogenic mechanisms related to the products of leader genes. Genes linking periodontitis and CRC were identified and classified in order of predominance, through an experimental investigation, performed via computer simulation, employing the leader gene approach. Pathogenic mechanisms relating to leader genes were determined through cross-search databases. Of the 83 genes linking periodontitis and CRC, 12 were classified as leader genes and were pathogenically implicated in cell cycle regulation and in the immune-inflammatory response. The current results, obtained via computer simulation and requiring further validation, support the existence of a genetic linkage between periodontitis and CRC. Cell cycle dysregulation and the alteration of the immuno-inflammatory response constitute the pathogenic mechanisms related to the products of leader genes.
Background:
Obesity represents one of the main health problems worldwide and is considered a risk factor for several diseases, including periodontitis, which is a microbially-associated inflammatory ...disease affecting the tooth-supporting structures.
Objective:
The aim of this review was to report the current direct and indirect evidence concerning the possible association between obesity and periodontitis and their putative molecular links.
Methods:
A literature search was conducted between January 1999 and September 2019, in PubMed/MEDLINE and Science Direct databases, using pertinent keyword combined by Boolean operators. Through a multi-step screening process (literature search; articles title and abstract evaluation and full-text reading), studies fitting inclusion/exclusion criteria were considered for the review.
Results:
35 studies were included in the present review (17 observational studies; 7 systematic reviews; 11 systematic reviews with meta-analysis), focusing on the direct and indirect evidence of the possible association between obesity and periodontitis and their potential etiopathogenic molecular links
Conclusion:
Although the majority of the studies reported a positive association between obesity and periodontitis, the heterogeneity of the classification criteria and of the clinical parameters employed in the studies for both obesity and periodontitis evaluation, complicated the comparison of the results, thus considered inconclusive. Although several putative molecular pathogenic links between obesity and periodontitis have been highlighted, further studies, with longer follow-ups and with homogeneous clinical criteria, are needed to better understand the putative relation between obesity and periodontal disease.
Hyperlipidemia is a well-recognized risk factor for cardiovascular disease, which, in turn, acts as a contributory factor in periodontitis development. Periodontitis has been associated with benign ...tumors and cancers and withseveral disorders, including hyperlipidemia. Correspondingly, periodontal treatment may exert a positive effect on lipid metabolism, although opposite evidence has also been reported. As a counterpart, the therapy for hyperlipidemia, conventionally based on statins, has been proposed to positively affect periodontal conditions, mainly due to statin pleiotropic effects, reducing periodontal inflammation and promoting osseointegration. Therefore, the present systematic review aimed to evaluate, in subjects with untreated periodontitis and peri-implant disease (Population), the effect of routine systemically administered statins (Intervention), compared to non-statin use (Comparison), on periodontal parameters around natural teeth and implants (Outcome). Discordant results were found in periodontal parameters, and the current lack of such data related to peri-implant tissues and to alveolar bone loss highlights the need for further studies on the topic, potentially paving the way for a more comprehensive approach to periodontitis and peri-implantitis management. Indeed, the validation of the beneficial effect provided by systemically delivered statins on periodontal and peri-implant tissues may direct recall scheduling, predict response to therapy and, therefore, guide treatment strategies of periodontal and peri-implant treatments in statin users.
Oral pathogens have been identified in bioptic specimens from Age-Related Macular Degeneration (ARMD) patients, and alveolar bone loss has been related to ARMD. Therefore, the possible association ...between ARMD and periodontal disease was investigated in the present case-control study, evaluating clinical and radiographic periodontal parameters, primarily, in cases vs. controls and, secondarily, in relation to ARMD risk factors, in cases, to highlight a possible pathogenic link between the disorders. Forty ARMD cases and 40 non-ARMD controls, matched for age (±3 years) and gender and homogeneous for ARMD risk factors, therefore comparable, underwent full-mouth periodontal charting, panoramic radiograph, and medical data, including ARMD risk factors, collection. Statistical analysis was conducted using the language R. Comparisons between groups were made using both traditional
-tests and Yuen's test with bootstrap calibration. Enrolled subjects were ≥55 years old, and 50 females and 30 males were equally distributed among the two groups. No statistically significant difference was found in clinical and radiographic periodontal parameters in cases vs. controls. In the case group, no differences were found when relating the periodontal parameters to ARMD risk factors, except for Clinical Attachment Level values that were statistically significantly higher in hypertensive ARMD subjects. A possible association between periodontal disease and ARMD may be hypothesized in hypertensive ARMD subjects, with hypertension as a possible pathogenic link between the disorders.
Background. One of the most important aims of an endodontic treatment is to obtain the complete removal or reduction of root canal remaining filling material: Smear layer, bacteria, intra-canal ...medicaments. To meet this requirement, several irrigation activation techniques have been proposed. Our systematic review examined studies which analyzed the XP-endo Finisher (XPF) instrument efficacy in removing root canal debris during initial endodontic treatment or retreatment, comparing it with the efficacy of other irrigation activation protocols, such as passive ultrasonic irrigation (PUI), laser activation procedure (Er:YAG), and Self-Adjusting File system (SAF). Methods. A systematic review was conducted using PubMed, Chocrane Library, and Scopus databases, identifying 51 items. Thirty-four articles were excluded based on title, abstract, full text, and language. Seventeen randomized controlled trials were selected and consequently submitted to quality assessment and data collection. Results. Conventional needle irrigation (CNI) is the less effective irrigation technique, but it is still unclear whether XPF is able to guarantee greater debris removal than the PUI technique. Er:YAG laser has been proven to be more effective in apical third than XPF instrument. Conclusions. Further investigations are needed in order to establish which final irrigation activation procedure could reach the maximum root canal debris reduction.
Tribology and Dentistry: A Commentary Lanza, Antonio; Ruggiero, Alessandro; Sbordone, Ludovico
Lubricants,
06/2019, Volume:
7, Issue:
6
Journal Article
Peer reviewed
Open access
Since 1966 the term “tribology” has integrated different topics like friction, lubrication and wear. After a few years, interest in this type of phenomena rapidly spread out around the world of ...biology and medicine, determining a new research area defined as biotribology. This commentary is conceived within this framework with the aim of underlining the close link between tribology and dentistry regarding both physiological and restorative issues. The contact between teeth requires investigation into their tribological behavior focusing on the enamel wear process against natural teeth and/or artificial teeth, allowing us to obtain useful information on the tribological behavior of restorative materials. Thus, tested materials may be natural teeth, restorative materials (metal alloys, ceramics, composites) or both. This work aims to make a contribution to underlining the need for greater standardization of tribological experimental procedures as well as to obtaining more homogeneous and indicative results on the tested tribo systems.
The aim of the present retrospective chart review was to analyze by Computed Tomography (CT) scan technique the degree of maxillomandibular atrophies, searching for differences between totally- and ...partially-edentulous subjects, and possibly identify and classify maxillomandibular atrophy staged patterns for implant planning in both totally- and partially- edentulous jaws.
CT scans of 89 mandibles and 77 maxillae from 111 patients were classified according to six different patterns of residual ridge resorption and to two different groups of edentulism (totally- and partially-edentulous). Maxillomandibular absolute linear dimensions were calculated and results compared for statistically significant differences by Wilcoxon tests.
Maxillomandibular CT cross-section interpretation showed different patterns of linear bone remodelling (height values) between the two groups of edentulism joined with specific positions in the maxilla or mandible. The judgment of the investigator was uncertain in the analysis of the mandibular posterior areas with similar percentages for both totally- and partially-edentulous groups (12.5% and 11.5%, respectively).
The 3D analysis is self-explanatory and easy to apply, aided by CT scans. The measurements between the referring planes and inviolable anatomical structures (nasal floor NFD, lower border of mandible LBD, inferior alveolar nerve AND, and sinus floor SFD), showed that class III may not guarantee an optimal implant placement, especially in the totally-edentulous group, due to a major degree of pneumatisation.
Objectives
The purpose of this study was to determine the existence of correlations between marginal peri-implant linear bone loss and the angulation of implants in maxillary and mandibular augmented ...areas over the course of a 2-year survey.
Materials and methods
Dependent variables described the sample of the present retrospective chart review. By using three-dimensional radiographs, input variables, describing the implant angulation (buccal–lingual angle
φ
and mesial–distal angle
θ
) were measured; outcome variables described survival rate and marginal bone resorption (MBR) around dental implants in autogenous grafts (10 maxillae and 14 mandibles). Pairwise comparisons and linear correlation coefficient were computed.
Results
The peri-implant MBR in maxillary buccal and palatal areas appeared less intensive in the presence of an increased angulation of an implant towards the palatal side. Minor MBR was recorded around mandibular dental implants positioned at a right angle and slightly angulated towards the mesial.
Conclusions
Resorption in buccal areas may be less intensive as the angulation of placed implants increases towards the palatal area in the maxilla, whereas for the mandible, a greater inclination towards the lingual area could be negative. In the mandibular group, when the implant was slightly angulated in the direction of the distal area, bone resorption seemed to be more marked in the buccal area.
Clinical relevance
In the planning of dental implant placement in reconstructed alveolar bone with autograft, the extremely unfavourable resorption at the buccal aspect should be considered; this marginal bone loss seemed to be very sensitive to the angulation of the dental implant.
Since non-adherence to antibiotic therapy can cause several problems, including antimicrobial resistance (AMR) and treatment failures, the present study evaluated adherence to oral antibiotic therapy ...and AMR awareness among consecutively enrolled dental patients. Data concerning age, gender, socioeconomic status, education level, cohabitation, and general health were retrieved from medical records. AMR awareness was investigated through direct questions and adherence to antibiotic treatment was assessed through a modified Italian version of the Morisky medical scale-8 items. Participants’ characteristics were analyzed in relation to treatment adherence and AMR, using a Χ2 independence test (significance level of α <0.1). Dental patients generally showed a low (51.82%) adherence to oral antibiotic therapy, and medium and high adherence was reported only by 29.37% and 18.81% of participants. Treatment adherence was similar in relation to participants’ gender and age but significantly lower in subjects with only secondary school graduation and higher in participants with higher education levels. Non-cohabitants were significantly more adherent than cohabitants. AMR awareness was declared by 42.15% of males and 38.70% of females: 56.52% of dental patients aware of AMR were 18−38 years old, 35.20% were 39−59 years old, and 26.95% were aged between 60 and 80. Further studies are needed to develop adequate strategies, expanding dental patients’ knowledge of AMR, thus optimizing the benefits and reducing the risks of antibiotic administration in dental patients.
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