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  • Impact of multiple patholog... Impact of multiple pathologies on the threshold for clinically overt dementia
    Kapasi, Alifiya; DeCarli, Charles; Schneider, Julie A. Acta neuropathologica, 08/2017, Volume: 134, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Longitudinal clinical–pathological studies have increasingly recognized the importance of mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular disease pathologies) ...
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  • Relation of cerebral vessel... Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study
    Arvanitakis, Zoe, Prof; Capuano, Ana W, PhD; Leurgans, Sue E, Prof ... Lancet neurology, 08/2016, Volume: 15, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Summary Background Few data on the pathology of cerebral vessel disease, dementia, and cognition are available. We examined the association of cerebral atherosclerosis and arteriolosclerosis ...
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  • Overview and findings from ... Overview and findings from the religious orders study
    Bennett, David A; Schneider, Julie A; Arvanitakis, Zoe ... Current Alzheimer research, 07/2012, Volume: 9, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer's disease (AD). In this manuscript, we summarize the study methods including the study design and ...
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  • Sex differences in Alzheime... Sex differences in Alzheimer’s disease and common neuropathologies of aging
    Oveisgharan, Shahram; Arvanitakis, Zoe; Yu, Lei ... Acta neuropathologica, 12/2018, Volume: 136, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Alzheimer’s dementia is significantly more common in women than in men. However, few pathological studies have addressed sex difference in Alzheimer’s disease (AD) and other brain pathologies. We ...
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  • Vascular Cognitive Impairme... Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel
    Iadecola, Costantino; Duering, Marco; Hachinski, Vladimir ... Journal of the American College of Cardiology, 07/2019, Volume: 73, Issue: 25
    Journal Article
    Peer reviewed

    Cognitive impairment associated with aging has emerged as one of the major public health challenges of our time. Although Alzheimer's disease is the leading cause of clinically diagnosed dementia in ...
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  • Person‐specific contributio... Person‐specific contribution of neuropathologies to cognitive loss in old age
    Boyle, Patricia A.; Yu, Lei; Wilson, Robert S. ... Annals of neurology, January 2018, 2018-01-00, 20180101, Volume: 83, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Objective Mixed neuropathologies are the most common cause of dementia at the population level, but how different neuropathologies contribute to cognitive decline at the individual level remains ...
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  • Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology
    Ayton, Scott; Wang, Yamin; Diouf, Ibrahima ... Molecular psychiatry, 11/2020, Volume: 25, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of the directly measured iron on the clinical syndrome has not been assessed. We investigated the association ...
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  • Human and mouse single-nucl... Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease
    Zhou, Yingyue; Song, Wilbur M; Andhey, Prabhakar S ... Nature medicine, 01/2020, Volume: 26, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of ...
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  • Attributable risk of Alzhei... Attributable risk of Alzheimer's dementia attributed to age‐related neuropathologies
    Boyle, Patricia A.; Yu, Lei; Leurgans, Sue E. ... Annals of neurology, January 2019, Volume: 85, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Objective The degree to which Alzheimer's versus other neuropathologies contribute to the risk of Alzheimer's dementia is unknown. We examined the risk of Alzheimer's dementia attributable to ...
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  • Single cell RNA sequencing ... Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease
    Olah, Marta; Menon, Vilas; Habib, Naomi ... Nature communications, 11/2020, Volume: 11, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    The extent of microglial heterogeneity in humans remains a central yet poorly explored question in light of the development of therapies targeting this cell type. Here, we investigate the population ...
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