BackgroundIn the USA, ∼300 000 people are affected by Chagas heart disease, a growing, but commonly overlooked, public health issue. Chagas as a potential aetiology of dilated cardiomyopathy remains ...under-recognized. We present a case where multimodality imaging was essential in the diagnosis and management of Chagas heart disease. Case summaryA 54-year-old man, originally from Mexico, presented to the emergency department with chest pain and recurrent syncopal episodes, found to be in haemodynamically unstable ventricular tachycardia (VT) requiring urgent cardioversion. Urgent coronary angiography revealed no obstructive disease. A transthoracic echocardiogram revealed moderately reduced left ventricular systolic function (left ventricular ejection fraction 35-40%) with apical akinesis and an aneurysm of the apical septum. Cardiac magnetic resonance (CMR) confirmed a prominent apical aneurysm with dyskinesis of the apical septum, with the evidence of transmural myocardial late gadolinium enhancement of the entire left ventricular apex and a small apical thrombus. Serologic testing was positive for Trypanosoma cruzi IgG antibody, which was confirmed on repeat testing at the Centers for Disease Control and Prevention. Patient underwent VT ablation and was discharged on guideline-directed medical therapy including a regimen of anticoagulation, beta-blocker, and angiotensin-converting enzyme inhibitor therapies. He has had no subsequent syncope or VT. DiscussionChagas heart disease remains under-recognized and under-diagnosed despite the growing burden of T. cruzi infection in the USA. Suspicion for Chagas heart disease should be considered in patients presenting with heart failure symptoms and ventricular arrhythmias with the right corresponding history and imaging findings on echocardiogram and CMR.
We aim to describe the demographics, clinical presentation, hospital course, and severity of pediatric inpatients with coronavirus disease 2019 (COVID-19), with an emphasis on healthy, ...immunocompromised, and chronically ill children.
We conducted a single-center retrospective cohort study of hospitalized children aged younger than 22 years with COVID-19 infection at Steven and Alexandra Cohen Children's Medical Center at Northwell Health. Cases were identified from patients with fever and/or respiratory symptoms who underwent a nucleic acid amplification-based test for severe acute respiratory syndrome coronavirus 2.
Sixty-five patients were identified. The median age was 10.3 years (interquartile range, 1.4 months to 16.3 years), with 48% of patients older than 12 years and 29% of patients younger than 60 days of age. Fever was present in 86% of patients, lower respiratory symptoms or signs in 60%, and gastrointestinal symptoms in 62%. Thirty-five percent of patients required ICU care. The white blood cell count was elevated in severe disease (
= .0027), as was the C-reactive protein level (
= .0192), compared with mild and moderate disease. Respiratory support was required in 34% of patients. Severity was lowest in infants younger than 60 days of age and highest in chronically ill children; 79% of immunocompromised children had mild disease. One death was reported.
Among children who are hospitalized for COVID-19, most are younger than 60 days or older than 12 years of age. Children may have severe infection requiring intensive care support. The clinical course of immunocompromised patients was not more severe than that of other children. Elevated white blood cell count and C-reactive protein level are associated with greater illness severity.
Abstract
We present the design and performance of the GROWTH-India telescope, a 0.7 m robotic telescope dedicated to time-domain astronomy. The telescope is equipped with a 4k back-illuminated camera ...that gives a 0.°82 field of view and a sensitivity of
m
g′
∼ 20.5 in 5 minute exposures. Custom software handles observatory operations: attaining high on-sky observing efficiencies (≳80%) and allowing rapid response to targets of opportunity. The data processing pipelines are capable of performing point-spread function photometry as well as image subtraction for transient searches. We also present an overview of the GROWTH-India telescope’s contributions to the studies of gamma-ray bursts, the electromagnetic counterparts to gravitational wave sources, supernovae, novae, and solar system objects.
The objectives of the current study was to evaluate the disinfection efficacy of ozone, ultraviolet (UV) radiation, herbal and glutaraldehyde method for sterilization of elastomeric impression ...materials.
Disinfection of elastomeric impression material was performed with each of the disinfection methods: ozone, UV radiation, herbal, and glutaraldehyde. Later microbiological analysis was performed and the colony-forming units were evaluated and compared.
The highest disinfection efficacy was found with glutaraldehyde, followed by ozone and UV radiation, and the least with neem herbal rinse. Intergroup comparison was highly significant.
Dry gaseous ozone and UV radiation can be used effectively for the disinfection of impressions.
The formation of unique morphologies of zinc oxide (ZnO) super structured frameworks were reported via a simple and eco-friendly route employing Vitis labruska fruit Black Grape Skin (BGS) extract as ...a fuel. XRD, FTIR, UV–vis, PL, SEM and TEM studies are performed to analyse the formation and characterization of ZnO. XRD confirmed the crystalline nature of the material with hexagonal Wurtzite structure having average crystallite size of ~50nm. FTIR spectrum shows a band at 532cm−1 due to the vibrational mode of Zn-O bending. The band gap of the ZnO was found to be 3.26eV. SEM images confirm the formation of different morphologies like Mysore pak (a popular Indian dessert), canine teeth, hollow pyramids and gems were obtained by varying the weight of BGS. These superstructures were obtained due to the interaction of Zn2+ with BGS extract. TEM images clearly shows lattice spacing of 0.29nm corresponding to the (002) plane of ZnO. Photoluminescence (PL) spectrum shows strong yellow light emission upon excitation at 320nm due to the Zn-O defects. Synthesized ZnO nanoparticles (Nps) exhibited good photocatalytic activity for the degradation of Methylene blue (MB) dye. The photocatalytic activity was due to the production of OH˙ radicals during photo irradiation on ZnO Nps. ZnO Nps also exhibited superior antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. Further, ZnO Nps were also used in the development of novel electrochemical sensing platform towards the electrochemical detection of hydrazine as a model system at very low concentrations having a detection limit of 0.3µM.
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•For the first time BGS assisted nanocrystalline ZnO superstructures were prepared.•The mechanism for the trapping of Zn2+ ions was discussed.•Super structured ZnO NPs shows strong yellow emission for UV excitation.•Synthesized ZnO NPs shows a good photocatalyst and good antibacterial properties.•It also used for electrochemical sensor for trace level concentration upto 0.3µM.
Let q=pm, where p is a prime and m∈N. Let Fqn be the field extension of degree n over Fq. Further, let r≥1 and k≥0 be integers such that r|qn−1 and there exists a k degree polynomial g(x)|xn−1. Let ...ξ∈Fq⁎ be an ω-primitive element i.e. the multiplicative order of ξ is (qn−1)/ω, where ω=gcd(r,q−1), and ζ∈Fq be any arbitrary element.
In this article, we establish a sufficient condition for the existence of an r-primitive k-normal element α∈Fqn such that NFqn/Fq(α)=ξ and TrFqn/Fq(α)=ζ. Using this sufficient condition, we show that, for fixed integers r and k there always exists an r-primitive k-normal element with prescribed norm ξ and trace ζ in all but finitely many finite fields Fqn, for n≥4k+5.
In this paper, a non-linear mathematical model for the effects of awareness programs on the spread of infectious diseases such as flu has been proposed and analyzed. In the modeling process it is ...assumed that disease spreads due to the contact between susceptibles and infectives only. The growth rate of awareness programs impacting the population is assumed to be proportional to the number of infective individuals. It is further assumed that due to the effect of media, susceptible individuals form a separate class and avoid contact with the infectives. The model is analyzed by using stability theory of differential equations. The model analysis shows that the spread of an infectious disease can be controlled by using awareness programs but the disease remains endemic due to immigration. The simulation analysis of the model confirms the analytical results.
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