This paper aims to demonstrate some solutions of a new method for constructing modal interfaces for information structure of a smart Gallery, which allows using the context-oriented calculations and ...subject-oriented knowledge base to offer the user the most suitable interface, based on available resources, situations, context, preferences and constraints. The developed foundations are based on subject-oriented knowledge bases.
In the paper, a class of impulsive Caputo fractional-order bi-directional associative memory neural networks with time-varying delays is considered. Applying the fractional Lyapunov method, a ...sufficient condition for Mittag-Leffler stability of the equilibrium point of the system under consideration is derived. Some earlier results are extended and improved. Our results provide an impulsive control law which stabilizes the impulse-free fractional-order neural network time-delay model. An example is provided to demonstrate the effectiveness of the proposed results.
This work presents the approaches used in the process of design of a system with the purpose to transmit the measurements sampled at certain space coordinates along with the exact sampling position, ...biological data, provide information about certain events happening in the area of the interest. The aim is to obtain an optimal design solution in order to implement stable and reliable hardware platform based on the current design. This paper is the first of series of two papers that present the creation of a system from a conceptual design to working equipment.
The present paper is devoted to Bidirectional Associative Memory (BAM) Cohen–Grossberg-type impulsive neural networks with time-varying delays. Instead of impulsive discontinuities at fixed moments ...of time, we consider variable impulsive perturbations. The stability with respect to manifolds notion is introduced for the neural network model under consideration. By means of the Lyapunov function method sufficient conditions that guarantee the stability properties of solutions are established. Two examples are presented to show the validity of the proposed stability criteria.
For decades, museum specialists have kept their research on paper precious invaluable work. Today, this lost knowledge can be made available again. By digitalizing these studies and providing them ...with open access will offer scope for a deeper study of the Bulgarian cultural heritage, an integral part of which are the works of the investigators, ethnographers, historians, archaeologists. The paper gives a further look into the process of digitalizing old studies related to the cultural heritage initially from the archives of Regional historical museum Burgas. The described model is universal and can be a base for other cultural organizations that would like the ability to open their archives up to third parties, make them easy accessible, easy to maintain and become more sustainable.
A neural-network model of fractional order with impulsive perturbations, time-varying delays, and reaction-diffusion terms is investigated in this article. The focus is on investigating qualitative ...properties of the states and developing new almost periodicity and stability criteria. The uncertain case is also considered. Examples are established and the effectiveness of the obtained criteria is demonstrated.
This paper aims to demonstrate some solutions of a new method for constructing modal interfaces for information structure of a smart Gallery, which allows using the context-oriented calculations and ...subject-oriented knowledge base to offer the user the most suitable interface, based on avail-able resources, situations, context, preferences and constraints. The developed foundations are based on subject-oriented knowledge bases.
Models with uncertain values of their parameters are of a practical significance in different fields of science and technology. Uncertainty in the competitive models can greatly affect their ...dynamical behavior and, therefore, the analysis of the effects of uncertain terms in such models is very important in both theory and application. In this paper, we extend the existing N-species impulsive competitive models to the uncertainty case. The existence of a unique strictly positive and robustly exponentially stable almost periodic solution is investigated for the model. The main results are obtained by using Lyapunov-type functions and a comparison principle.
Background
BAY 81-8973 is a full-length, unmodified, recombinant human factor VIII (FVIII) for the treatment of hemophilia A.
Objective
The aim of this study was to compare the pharmacokinetic (PK) ...profile of BAY 81-8973 with antihemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM)
Patients/Methods
In this phase I, open-label, crossover study, men aged 18–65 years with severe hemophilia A and ≥150 exposure days to FVIII were randomized to receive a single intravenous infusion of 50 IU/kg BAY 81-8973 or rAHF-PFM, followed by crossover to a single infusion of the other treatment. FVIII levels were measured in plasma over 48 h using one-stage and chromogenic assays. PK parameters, including area under the curve from time zero to the last data point (AUC
last
; primary outcome) and half-life (
t
½
) were calculated. A population PK model was developed to simulate various treatment scenarios.
Results
Eighteen patients were randomized and analyzed. Using both assays, geometric mean (coefficient of variation %CV) AUC
last
was significantly higher, and
t
½
was significantly longer, for BAY 81-8973 versus rAHF-PFM (one-stage, AUC
last
: 1660 IU·h/dL 29.4 vs. 1310 IU·h/dL 29.0,
p
< 0.0001; one-stage,
t
½
: 14.5 25.7 vs. 11.7 h 27.3,
p
< 0.0001). Simulations showed that median time to 1 IU/dL was approximately 27% longer for BAY 81-8973 versus rAHF-PFM over doses of 25–50 IU/kg; plasma levels >1 IU/dL could be maintained with 14.4 IU/kg BAY 81-8973 or 39.1 IU/kg rAHF-PFM 3×/week.
Conclusions
BAY 81-8973 showed a superior PK profile versus rAHF-PFM. The same FVIII trough threshold level could be achieved with lower doses of BAY 81-8973 versus rAHF-PFM.
ClinicalTrials.gov: NCT02483208.
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