•The Atlas stent shows promise as a safe and effective treatment option for intracranial stenosis.•The use of the Gateway catheter to deliver the stent appears to be associated with a lower risk of ...post-procedural stroke compared to using the microcatheter.•The incidence of in-stent restenosis may be influenced by the degree of residual stenosis.
This study aimed to compare the safety and efficacy of the Atlas stent released by the Gateway catheter and microcatheter in the treatment of intracranial stenosis (IS).
The primary efficacy and safety outcomes were the in-stent restenosis (ISR) rate and post-procedural stroke or death within one month.
Atlas stents were deployed using the Gateway catheter and microcatheter in 19 (57.6 %) and 14 (42.4 %) procedures, respectively. Follow-up imaging data were available for 26 patients; the incidence of ISR was 15.4 %, and the ISR rate was higher, though not significantly, in the microcatheter group than in the Gateway group (30.0% vs. 6.25 %, P = .39). Clinical follow-up data were available for 30 patients; the post-procedural stroke rate was 3.3 % within one month and 13.3 % from one month to one year. The post-procedural stroke rate within one month was higher, though not significantly, in the microcatheter group than in the Gateway group (7.7% vs. 0 %, P = .43). The Gateway group had a significantly lower rate of post-procedural stroke in the same territory than that of the microcatheter group (0% vs. 30.8 %, P = .026). A higher incidence of residual stenosis <30 % was found in the non-ISR group than in the ISR group (72.2% vs. 0 %, P = .014).
This study provides preliminary evidence that the Atlas stent is safe and effective for IS treatment. The use of the Gateway catheter to deliver the Atlas stent appears to be safer than using microcatheter. The incidence of ISR may be related to the degree of the residual stenosis.
This study aims to share our experience with the arm-only combined transarterial and transvenous access approach for neurointerventional procedures and evaluate its efficacy and safety.
The arm-only ...combined transarterial and transvenous access approach was performed using the right/bilateral proximal radial arteries and the right forearm superficial vein system, guided by ultrasonic guidance. Arterial access closure was achieved using a transradial band radial compression device, while manual compression was utilized for venous approach closure.
Thirteen procedures were successfully performed using the arm-only combined transarterial and transvenous access approach, yielding favorable outcomes. The procedures included dural arteriovenous fistula embolization (seven cases), cerebral arteriovenous malformation embolization (four cases), venous sinus thrombosis catheter-directed thrombolysis and intravenous thrombectomy (one case), and cerebral venous sinus stenosis manometry (one case). All procedures were uneventful, allowing patients to ambulate on the same day. At discharge, all patients exhibited modified Rankin scores of 0-2, without any access site or perioperative complications.
This double-center study preliminarily demonstrates the feasibility and safety of arm-only combined transarterial and transvenous access applied in neurointerventional procedures for complicated cerebrovascular diseases. The proximal radial artery and forearm superficial vein are recommended as the primary access sites. Unobstructed compression is strongly recommended for radial approach closure.
This study aimed to add evidence and experience on the arm-only combined transarterial and transvenous access, as a new approach, for neurointerventional treatment that required arteriovenous approaches.
BP artificial neural network abbreviated as BP ANN is easy to fall into the local minimum point. But genetic algorithm abbreviated as GA could optimize the initial weights of BP ANN. So BP ANN with ...genetic algorithm abbreviated as GA BP ANN may overcome the shortcoming of pure BP ANN. However there are not researches on the forecast of steam turbine exhaust wetness fraction with GA BP ANN so far. By the research in this paper the prediction accuracy of GA BP ANN method is higher than pure BP method in the steam turbine exhaust wetness fraction forecast. Therefore GA BP ANN is a new method to calculate steam turbine exhaust wetness fraction and the method could meet the engineering applications demand.
Hybrid magnonic systems are a newcomer for pursuing coherent information processing owing to their rich quantum engineering functionalities. One prototypical example is hybrid magnonics in ...antiferromagnets with an easy-plane anisotropy that resembles a quantum-mechanically mixed two-level spin system through the coupling of acoustic and optical magnons. Generally, the coupling between these orthogonal modes is forbidden due to their opposite parity. Here we show that the Dzyaloshinskii-Moriya-Interaction (DMI), a chiral antisymmetric interaction that occurs in magnetic systems with low symmetry, can lift this restriction. We report that layered hybrid perovskite antiferromagnets with an interlayer DMI can lead to a strong intrinsic magnon-magnon coupling strength up to 0.24 GHz, which is four times greater than the dissipation rates of the acoustic/optical modes. Our work shows that the DMI in these hybrid antiferromagnets holds promise for leveraging magnon-magnon coupling by harnessing symmetry breaking in a highly tunable, solution-processable layered magnetic platform.
The Earth rotation parameters (ERPs), including polar motion (PMX and PMY) and universal time (UT1-UTC), play a central role in functions such as monitoring the Earth’s rotation and high-precision ...navigation and positioning. Variations in ERPs reflect not only the overall state of movement of the Earth, but also the interactions among the atmosphere, ocean, and land on the spatial and temporal scales. In this paper, we estimated ERP series based on very long baseline interferometry (VLBI) observations between 2011–2020. The results show that the average root mean square errors (RMSEs) are 0.187 mas for PMX, 0.205 mas for PMY, and 0.022 ms for UT1-UTC. Furthermore, to explore the high-frequency variations in more detail, we analyzed the polar motion time series spectrum based on fast Fourier transform (FFT), and our findings show that the Chandler motion was approximately 426 days and that the annual motion was about 360 days. In addition, the results also validate the presence of a weaker retrograde oscillation with an amplitude of about 3.5 mas. This paper proposes a hybrid prediction model that combines convolutional neural network (CNN) and long short-term memory (LSTM) neural network: the CNN–LSTM model. The advantages can be attributed to the CNN’s ability to extract and optimize features related to polar motion series, and the LSTM’s ability to make medium- to long-term predictions based on historical time series. Compared with Bulletin A, the prediction accuracies of PMX and PMY are improved by 42% and 13%, respectively. Notably, the hybrid CNN–LSTM model can effectively improve the accuracy of medium- and long-term polar motion prediction.
Display omitted
•DFT calculations well supported the predictions of the CD-MUSIC model.•Facet-dependent adsorption configurations mainly influenced the competition in an acidic environment.•Sb(V) can ...be selectively adsorbed by HNR in acidic environments with less interference from As(V).•As(V) and Sb(V) may compete for outer-sphere sites, particularly in alkaline environments.
The environmental mobility and fate of arsenic (As) and antimony (Sb) are influenced by ubiquitous iron minerals, but little is known about whether their co-adsorption behavior is affected by the exposed facets. Herein, we used cubic and rod-shaped hematite nanocrystals (HNC and HNR) to investigate the effect of exposed facets on competitive adsorption behaviors. TEM analysis indicated that the primary exposed facets of HNC and HNR were {110} and {012}, separately. Calculations supported the predictions of our model, revealing that the competition in acidic and alkaline environments was mainly influenced by the affinity and bond stability of facet-related adsorption configurations. However, the competition in neutral conditions was jointly influenced by facet-related coordination and adsorption behavior, due to the dependence of Sb(V) on protonation sites. On HNR (pH = 3), the adsorption of Sb(V) (50.6 %) was approximately twice that of As(V) (27.8 %) for its significant advantage in bidentate coordination on the {110} facet, whereas on HNC, As(V) (65.9 %) and Sb(V) (69.3 %) exhibited similar competitiveness. Notably, As(V) and Sb(V) tend to be adsorbed through outer-sphere coordination under alkaline conditions. On the {012} facet, As(V) and Sb(V) exhibited similar competitiveness for outer-sphere sites, whereas on the {110} facet, As(V) outer-sphere coordination showed stronger affinity, giving it an edge in competing on HNR. Overall, this study elucidated the critical role of varying exposed facets in the competitive adsorption process and proposed novel strategies for the selective removal of coexisting As(V) and Sb(V) through tailored fixed-facet iron oxides.
As an emerging technique, mode division multiplexing (MDM) can effectively increase the data capacity in communication networks. High-performance multimode waveguide bends with small device ...footprints play an indispensable role in multimode photonics and MDM technique. Previously reported multimode waveguide bends still face the challenge of limited number of supported modes and relatively large device footprint. To tackle these challenges, based on the intelligent inverse design algorithm that combines adaptive genetic algorithm (AGA) and finite element method (FEM) simulation, a kind of multimode waveguide bend based on superellipse curves and shallowly-etched subwavelength nanoslots is proposed in this work. Numerical simulation results confirm that the multimode waveguide bends can support up to 5 TE modes and 8 TE/TM modes (4 TE + 4 TM), whose bending radius is only 3.55 and 3.25 μm, respectively. All devices can be characterized as ultra-sharp 90° multimode waveguide bends with low loss and low crosstalk. Moreover, this work reconfirms the good generality of our intelligent design methodology, which can be applied to the design and optimization of various photonic devices. Meanwhile, the proposed multimode waveguide bends hold good prospect in application of MDM techniques in multimode silicon photonics.
Background Circulating tumor DNA (ctDNA) has been proven to be a promising tumor-specific biomarker in solid tumors, but its clinical utility in risk stratification and early prediction of relapse ...for diffuse large B cell lymphoma (DLBCL) has not been well explored. Methods Here, using a lymphoma-specific sequencing panel, we assessed the prognostic and predictive utilities of ctDNA measurements before, during, and after first-line therapy in 73 Chinese DLBCL patients. Results The pretreatment ctDNA level serving as an independent prognostic factor for both progression-free survival (PFS, adjusted HR 2.47; p = 0.004) and overall survival (OS, adjusted HR 2.49; p = 0.011) was confirmed in our cohort. Furthermore, the patients classified as molecular responders who presented a larger decrease in ctDNA levels after the initial two treatment cycles had more favorable PFS (unreached vs. 6.25 months; HR 5.348; p = 0.0015) and OS (unreached vs. 25.87; HR 4.0; p = 0.028) than non-responders. In addition, interim ctDNA clearance may be an alternative noninvasive method of positron emission tomography and computed tomography (PET-CT) for predicting better PFS (HR 3.65; p = 0.0033) and OS (HR 3.536; p = 0.016). We also demonstrated that posttreatment ctDNA was a sensitive indicator for detecting minimal residual disease (MRD) in patients with a high risk of recurrence (HR 6.471; p = 0.014), who were otherwise claimed to achieve radiographic CR (complete remission). Conclusions CtDNA is a promising noninvasive tool for prognosis prediction, response assessment, and early relapse prediction of first-line treatment in DLBCL patients. Keywords: Diffuse large B cell lymphoma, Circulating tumor DNA, Minimal residual disease
Purpose
Although papillary thyroid cancer (PTC) has a low mortality rate, the rate of recurrence remains relatively high. This study aims to develop a molecular signature to predict the recurrence of ...PTC.
Methods
A total of 333 PTC patients’ data from The Cancer Genome Atlas (TCGA) were included. We calculated tumor mutation burden (TMB) and analyzed the mutation status of BRAF and TERT promoter.
Results
Tumor recurrence occurred in 17 of 263 cases in TMB-L patients versus 14 of 70 cases in TMB-H patients (hazard ratio HR, 3.55; 95% confidence interval CI, 1.75–7.21;
P
< 0.001). The HR for recurrence in TMB-H patients remained significant after adjustment for classical clinicopathologic factors (patient age, gender, extrathyroidal extension and lymph node metastasis). These clinical factors had no effect on recurrence rate in TMB-L patients, but had a strong adverse effect on the prognosis of TMB-H patients. Compared with TMB-L patients lacking mutation, the HR (95% CI) of recurrence for TMB-H patients with coexisting BRAF V600E and/or TERT C228/250 T mutations was 6.68 (2.41–18.57), which remained significant after adjustment for clinicopathological factors. The mutation status of BRAF V600E and TERT C228/250 T had little effect on PTC recurrence in TMB-L patients. Either of the mutation was associated with high recurrence rate in TMB-H patients.
Conclusions
The presence of BRAF V600E and/or TERT promoter mutations denotes a high risk of recurrence in TMB-H patients. This represents a powerful molecular prognostic genotype that can help predict patients with the highest risk of recurrence.
Core fucosylation catalyzed by core fucosyltransferase (Fut8) contributes to the progressions of epithelial ovarian cancer (EOC). Copper transporter 1 (CTR1), which contains one N‐glycan on Asn15, ...mediates cellular transport of cisplatin (cDDP), and plays an important role in the process of cDDP‐resistance in EOC. In the present study, we found that the core fucosylation level elevated significantly in the sera of cDDP‐treated EOC patients. The in vitro assays also indicate that core fucosylation of CTR1 was significantly upregulated in cDDP‐resistant A2780CP cells compared to the cDDP‐sensitive A2780S cells. Intriguingly, the hyper core fucosylation suppressed the CTR1‐cDDP interactions and cDDP‐uptake into A2780CP cells. Conversely, contrast to the Fut8+/+ mouse ovarian epithelial cells, the Fut8‐deleted (Fut8−/−) cells obviously showed higher cDDP‐uptake. Furthermore, the recovered core fucosylation induced the suppression of cDDP‐uptake in Fut8‐restored ovarian epithelial cells. In addition, the core fucosylation could regulate the phosphorylation of cDDP‐resistance‐associated molecules, such as AKT, ERK, JNK, and mTOR. Our findings suggest that the core fucosylation of CTR1 plays an important role in the cellular cDDP‐uptake and thus provide new strategies for improving the outcome of cDDP based chemotherapy of EOC.
