In modern cities, the investigation of an outbreak using the traditional systems is a time- consuming task that requires collecting and processing complex information in order to track the origin of ...the disease. The COVID-19 Virus shows the current system limitation. For this reason, establishing an early detection and prediction is essential to halt the spreading of epidemics in an earlier stage. The aim of our work is to design a system capable of detecting and forecast people carrying of an epidemic in the first days of incubation using geolocation of the patient's and big data.
Multiparity, risk factor of maternal and foetal morbidity and mortality, is a worldwide public health problem. In Tunisia, in spite of the activities of the national program of maternal and infantile ...health implanted since 1966, the multiparity is yet observed in some regions of our country. Our objective is to draw up the epidemiological profile of the multipara woman (parity<6) and the grand multipara (parity> or =6) in the sanitary district of Monastir and to study the chronological tendencies of the factors associated during a decade (from 1994 to 2003).
In all, 16649 multipara were studied, representing 24% of the total women admitted for childbirth in the public motherhoods of the district. The global means age was 33,3 +/- 4,5 years with a statistical significance between multipara and grand multipara (32,7 and 35,6 respectively). The prenatal follow up was absent or inadequate for 50,2% of multipara and 62,8% of the grand multipara (p <0,001).
In the decade, the main chronological tendencies are similar in the two multipara groups. Their frequency decreased from 28,5 to 19% (p<0,001), yet the age and the adequate follow up increased from 32,6 to 34 years and from 37,4 to 57,9% respectively (p<0,001).
Although the multiparity is decreasing and its associated factors seem to improve, the vigilance is asked again in order to avoid the inherent risks.
p53 is one of the most important tumour suppressor proteins currently known. It is activated in response to DNA damage and this activation leads to proliferation arrest and cell death. The abundance ...and activity of p53 are tightly controlled and reductions in p53's activity can contribute to the development of cancer. Here, we show that Fam83F increases p53 protein levels by protein stabilisation. Fam83F interacts with p53 and decreases its ubiquitination and degradation. Fam83F is induced in response to DNA damage and its overexpression also increases p53 activity in cell culture experiments and in zebrafish embryos. Downregulation of Fam83F decreases transcription of p53 target genes in response to DNA damage and increases cell proliferation, identifying Fam83F as an important regulator of the DNA damage response. Overexpression of Fam83F also enhances migration of cells harbouring mutant p53 demonstrating that it can also activate mutant forms of p53.
IntroductionWe aimed to characterize and forecast type 2 diabetes mellitus (T2DM) disease burden between 2021 and 2050 in Qatar where 89% of the population comprises expatriates from over 150 ...countries.Research design and methodsAn age-structured mathematical model was used to forecast T2DM burden and the impact of key risk factors (obesity, smoking, and physical inactivity). The model was parametrized using data from T2DM natural history studies, Qatar’s 2012 STEPwise survey, the Global Health Observatory, and the International Diabetes Federation Diabetes Atlas, among other data sources.ResultsBetween 2021 and 2050, T2DM prevalence increased from 7.0% to 14.0%, the number of people living with T2DM increased from 170 057 to 596 862, and the annual number of new T2DM cases increased from 25 007 to 45 155 among those 20–79 years of age living in Qatar. Obesity prevalence increased from 8.2% to 12.5%, smoking declined from 28.3% to 26.9%, and physical inactivity increased from 23.1% to 26.8%. The proportion of incident T2DM cases attributed to obesity increased from 21.9% to 29.9%, while the contribution of smoking and physical inactivity decreased from 7.1% to 6.0% and from 7.3% to 7.2%, respectively. The results showed substantial variability across various nationality groups residing in Qatar—for example, in Qataris and Egyptians, the T2DM burden was mainly due to obesity, while in other nationality groups, it appeared to be multifactorial.ConclusionsT2DM prevalence and incidence in Qatar were forecasted to increase sharply by 2050, highlighting the rapidly growing need of healthcare resources to address the disease burden. T2DM epidemiology varied between nationality groups, stressing the need for prevention and treatment intervention strategies tailored to each nationality.
Carrageenophyte red seaweed from Oman, Hypnea bryoides, extracted using three different processes: an aqueous, a mild alkaline, and a more vigorous alkaline extraction was investigated. The resulting ...extract precipitated by alcohol was subject to chemical and rheological measurements. The total carbohydrate ranged from 36.78 to 41.65 g/100 g, and ash 39.04 to 43.11 g/100 g were the most abundant components in H. bryoides and contrary to the two, lipid content was found at a minimum ranging from 2.95 to 3.38 g/100 g. Alkali treatment with NaOH allowed complete conversion of kappa (κ) carrageenan form as detected by FTIR analysis. Total yield by alkali treatments gave higher yields (33%) compared with aqueous treatments (12%). However, subsequent aqueous treatment produced mixed carrageenan (μ and κ) with higher molecular weight compared with the alkali treatments which produced single carrageenan form (κ) with molecular weight of 4.1 × 105 Da. The effects of thermal history on gel–sol and sol–gel transition were investigated by differential scanning calorimeter (DSC) and rheology on a pure sample and 1.5% κ-carrageenan mixture added with 30 mM KCl. Transition temperatures from DSC and rheology showed comparable results and were in good agreement with those previously reported.
Mitral valve masses are uncommon. These tumors and tumor-like lesions may have similar morphological and clinical characteristics, but different outcomes. Unlike valvular tumors, caseous ...calcification of the mitral annulus (CCMA) is a benign degenerative disorder, commonly misdiagnosed, thus differentiating it from other mitral valve masses is important to avoid unnecessary surgery. Multimodality imaging can prove a valuable tool for definitive diagnosis. We present a case of a 72-year-old female patient, with coronary artery disease, referred for angina symptoms. Echocardiography detected a mass in the mitral valve annulus. Cardiac magnetic resonance imaging showed a mobile mass respecting the myocardium suggestion an atypical papillary fibroelastoma and surgery was indicated. However, the definitive diagnosis, after histological examination, was CCMA. The aim of this case report is to illustrate the difficulty in differentiating between mitral valve masses and the repercussion on the subsequent management, emphasizing the pivotal role of multimodality imaging.
Background
Intellectual disability is a form of neurodevelopmental disorders that begin in childhood and is characterized by substantial intellectual difficulties as well as difficulties in ...conceptual, social, and practical areas of living. Several genetic and nongenetic factors contribute to its development; however, its most severe forms are generally attributed to single‐gene defects. High‐throughput technologies and data sharing contributed to the diagnosis of hundreds of single‐gene intellectual disability subtypes.
Method
We applied exome sequencing to identify potential variants causing syndromic intellectual disability in six Sudanese patients from four unrelated families. Data sharing through the Varsome portal corroborated the diagnosis of one of these patients and a Tunisian patient investigated through exome sequencing. Sanger sequencing validated the identified variants and their segregation with the phenotypes in the five studied families.
Result
We identified three pathogenic/likely pathogenic variants in CCDC82, ADAT3, and HUWE1 and variants of uncertain significance in HERC2 and ATP2B3. The patients with the CCDC82 variants had microcephaly and spasticity, two signs absent in the two previously reported families with CCDC82‐related intellectual disability.
Conclusion
In conclusion, we report new patients with pathogenic mutations in the genes CCDC82, ADAT3, and HUWE1. We also highlight the possibility of extending the CCDC82‐linked phenotype to include spastic paraplegia and microcephaly.
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