To understand Clonorchis sinensis reinfection and the determinants of reinfection in endemic areas is important in establishment of control measures.
A prospective cohort study was implemented in ...Hengxian County, Guangxi, China. Individuals with C. sinensis infection were completely treated, and those cured were enrolled as study subjects and followed up for 3, 6, and 12 months. The reinfection frequency and incidence were calculated, and a multivariable Cox proportional hazard model was constructed to capture reinfection determinants.
Among 635 enrolled subjects, 436 (68.7%) completed follow-up. Of these, 177 (40.6%) were reinfected; 133 (75.1%) were reinfected once, 41 (23.2%) twice, and 3 (1.7%) three times. The incidence of reinfection was 64.0 per 100 person-years. Men (adjusted hazard ratio aHR, 1.67; 95% confidence interval CI, 1.14-2.44), those with underlying diseases (aHR, 1.41; 95% CI, 1.02-1.95), and those with moderate- or heavy-intensity infections (aHR, 1.45; 95% CI, 1.14-1.85) had increasing reinfection probabilities.
C. sinensis reinfection is high in endemic areas. Men and high-intensity infection are important determinants of reinfection. Repeated chemotherapy is necessary to control reinfection and its associated morbidities, especially in high-risk individuals. In addition, behavioral education is advised to decrease overall reinfection in endemic areas.
Castanopsis sclerophylla (Lindl.) Schott. is a canopy tree species of evergreen broad-leaved forests in subtropical China. In this study, the genetic diversity and population structure of C. ...sclerophylla were investigated by using chloroplast DNA sequences and nuclear microsatellite markers. Permutation tests with chloroplast DNA sequences indicated the presence of phylogeographic structure in C. sclerophylla. Based on nuclear microsatellite markers, Bayesian clustering analysis revealed eastern-to-western differentiation in C. sclerophylla, and the analysis of molecular variance suggested population divergence has arisen along the Xuefeng, Luoxiao, and Wuyi mountain ranges. The approximate Bayesian computation demonstrated that the genetic diversity pattern of C. sclerophylla could be explained by geographic isolation followed by secondary contact. Ecological niche modelling showed that distribution of C. sclerophylla shrank southward at the Last Glacial Maximum and expanded northward at the Mid Holocene. These results suggested that the uplift of the Xuefeng, Luoxiao, and Wuyi mountain ranges and the interglacial-glacial climate change shaped the genetic diversity of C. sclerophylla. The Luoxiao mountain range should be considered as a key conservation unit of C. sclerophylla due to its higher level of genetic diversity. Our study supplies important information for prioritizing the conservation and sustainable utilization of C. sclerophylla, and provides insight on the dynamics of evergreen broad-leaved forests in subtropical China.
Background:
While the community health service system was initially established in rural areas of mainland China, the utilization of community health service resources by the rural elderly population ...is not clear.
Methods:
Cross-sectional studies on the utilization of community health services by the rural elderly population in mainland China published within the last 10 years were retrieved from the China National Knowledge Infrastructure (CNKI), Wan Fang, Medline and Web of Science (WOS) databases. The quality of the article was evaluated by the Critical Appraisal Skills Programme (CASP), and obstacles to the utilization of community health services by the rural elderly population were analyzed based on the Andersen model.
Results:
Twenty-four studies were analyzed, and 3 gaps were found. (i) The cognition of rural elderly residents does not match the current health security system. (ii) There is a gap between the supply of health service resources in rural communities and the health needs of the elderly residents in these areas. (iii) The health services provided by rural primary health service institutions are not targeted.
Conclusions:
In mainland China, the provision of community health services to the rural elderly population has improved significantly. However, several factors from the individual level to the system level lead to low levels of access and utilization. This finding means that under the leadership of the government, it is necessary to integrate the strength of multiple departments to cooperate in improving the welfare system, policy publicity, health education, financial support, system guarantees and resource exchange and sharing for the elderly population in rural areas and to jointly promote community health services for the elderly population in rural areas.
As representatives of health information communication platforms accessed through mobile phones and mobile terminals, health-related WeChat public accounts (HWPAs) have a large consumer base in the ...Chinese-speaking world. However, there is still a lack of general understanding of the status quo of HWPAs and the quality of the articles they release.
The aims of this study were to assess the conformity of HWPAs to the Health on the Net Foundation Code of Conduct (HONcode) and to evaluate the suitability of articles disseminated by HWPAs.
The survey was conducted from April 23 to May 5, 2019. Based on the monthly (March 1-31, 2019) WeChat Index provided by Qingbo Big Data, the top 100 HWPAs were examined to evaluate their HONcode compliance. The first four articles published by each HWPA on the survey dates were selected as samples to evaluate their suitability. All materials were assessed by three raters. The materials were assessed using the HONcode checklist and the Suitability Assessment of Materials (SAM) score sheet. Data analysis was performed with SPSS version 17.0 (SPSS Inc, Chicago, IL, USA) and Excel version 2013 (Microsoft Inc, Washington DC, USA).
A total of 93 HWPAs and 210 of their released articles were included in this study. For six of the eight principles, the 93 HWPAs nearly consistently did not meet the requirements of the HONcode. The HWPAs certified by Tencent Corporation (66/93, 71%) were generally slightly superior to those without such certification (27/93, 29%) in terms of compliance with HONcode principles. The mean SAM score for the 210 articles was 67.72 (SD 10.930), which indicated "adequate" suitability. There was no significant difference between the SAM scores of the articles published by certified and uncertified HWPAs (P=.07), except in the literacy requirements dimension (t
=-2.418, P=.02).
The HWPAs had low HONcode conformity. Although the suitability of health information released by HWPAs was at a moderate level, there were still problems identified, such as difficulty in tracing information sources, excessive implicit advertisements, and irregular usage of charts. In addition, the low approval requirements of HWPAs were not conducive to improvement of their service quality.
We aimed to investigate the relationship between the synthesis of hydrogen sulfide (H
2
S) and the pancreatic acinar cell apoptosis in severe acute pancreatitis (SAP) rats, as well as analyse the ...potential apoptotic pathway involved in this process. Sixty rats had been equally divided into four groups: sham, SAP, SAP + sodium hydrosulfide (NaHS) and SAP + DL-propargylglycine (PAG). 24 h after SAP induction, all surviving animals of each group were sacrificed to collect blood and tissue samples for the following measurements: the level of serum H
2
S as well as the levels of tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), H
2
S synthesizing activity, CSE mRNA and protein expression, maleic dialdehyde (MDA) and myeloperoxidase (MPO) activity, the expression of Bax, Bcl-2, caspase-3, -8 and -9, the release of cytochrome
c
and the activation of nuclear factor-kappa B (NF-κB), ERK1/2, JNK1/2 and p38 in pancreas. Furthermore, in situ detection of cell apoptosis was examined and the severity of pancreatic damage was analyzed by pathological grading and scoring. Results Significant differences in every index except IL-10 had been found between the SAP, NaHS and PAG groups (
P
< 0.05). Treatment with PAG obviously induced the pancreatic acinar cell apoptosis as well as improved all the pathological changes and inflammatory parameters. In contrast, administration of NaHS significantly attenuated apoptosis in the pancreas and aggravated the severity of pancreatic damage. Moreover, the expressions of caspase-3, -8, -9 and the release of cytochrome
c
were all increased in the apoptotic cells, and the activity of NF-κB as well as the phosphorylation of ERK1/2, JNK1/2 and p38 decreased accompanying with the reduction of the serum H
2
S level. H
2
S plays a pivotal role in the regulation of pancreatic acinar cell apoptosis in SAP rats. The present results showed that inhibition of H
2
S synthesis provided protection for SAP rats via inducing acinar cell apoptosis. This process acted through both extrinsic and intrinsic apoptotic pathways, and may be regulated by reducing the activity of NF-κB.
Positron age-momentum correlation (AMOC) spectroscopy is applied to study the associations between the momentum distributions and positron annihilation in the toughened CE networks. The Doppler ...profile of the positron annihilation process is much broader for the toughened CE than pure CE network. This is due to positron trapping on high polar groups of the added elastomers or nano-CaCO3 and annihilation with the electrons of high momenta. The broadening momentum distribution of ortho-positronium annihilation process indicates that the pick-off annihilation process is strongly influenced by the added high polar elastomers or nano-CaCO3. The potential of AMOC spectroscopy for free volume analysis in polymer blends was demonstrated.
► AMOC can be applied to the analyses of interfacial properties in polymer blends. ► The Doppler profile is much broader for the toughened CE than pure CE network. ► Positron trapping on high polar groups of the modifiers is demonstrated by AMOC.
Detecting and Resolving Inconsistencies in Snort Sun, Xibin; Zhang, Du; Liu, Mingzhe ...
2018 IEEE 17th International Conference on Cognitive Informatics & Cognitive Computing (ICCICC),
2018-July
Conference Proceeding
Intrusion Detection Systems (IDSs) are part of the network security systems that can take active measures when they detect suspicious intrusions through monitoring network transmissions. By matching ...the incoming packets with the patterns established through access control rules, an IDS system can identify and detect network attacks, and take proactive responses. However, one of the major challenges for an IDS is that its effectiveness is only as good as the rules that collectively define the profiles of all the attacks it is capable of capturing. The detection knowledge as embodied in the rules can be incomplete, inconsistent, deficient, or not well-defined, making the network defense less effective, still vulnerable, or suffering from realtime performance degradation. In this paper, we use Snort as a backdrop to formally define eighteen types of knowledge deficiencies that can be found in an IDS, describe approaches to automatically detect those knowledge deficiencies, and propose resolution algorithms to eliminate the deficiencies in an attempt to incrementally improve the quality of its network defense knowledge. Our ultimate goal is to rely on perpetual learning to automatically, consistently, and contiuously improve an IDS's network defense performance over time.
Barkam-Luqu-Gulang deep seismic sounding profile runs from north of Sichuan Province to south of Gansu Province. It is located at the northeastern edge of Tibetan Plateau and crosses eastern ...A'nyemaqên suture zone. The upper crust structures around eastern A'nyemaqên suture zone and its adjacent area are reconstructed based on the arrival times of refracted Pg and Sg waves by using finite difference method, ray tracing inversion, time-term method and travel-time curve analysis. The results show that the depth variation of basement along profile is very strong as indicated by Pg and Sg waves. The basement rose in Zoigê basin and depressed in eastern A'nyemaqên suture zone, and it gradually rose again northward and then depressed. The results also indicate that eastern A'nyemaqên suture zone behaves as inhomogeneous low velocity structures in the upper crust and is inclined toward the south. Hoh Sai Hu-Maqên fault, Wudu-Diebu fault and Zhouqu-Liangdang fault are characterized by low velocity distributions with various scales. The distinct variation in basement depth occurred near Hoh Sai Hu-Maqên fault and Zhouqu-Liangdang fault, which are main tectonic boundaries of A'nyemaqên suture zone. Wudu-Diebu fault, located at the depth variation zone of the basement, possibly has the same deep tectonic background with Zhouqu-Liangdang fault. The strongly depressed basement characterized by low velocity distribution and lateral inhomogeneity in A'nyemaqên suture zone implies crushed zone features under pinching action.PUBLICATION ABSTRACT
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